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What's the differences between Niagen, NAD+, NM, NMN, NR and what is the best to get?

niagen nad nmn nad+

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#271 bluemoon

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Posted 25 May 2019 - 06:50 PM

It really clears up the brain fog for my 83 year old father.  He is noticably more coherent and less forgetful.

 

 

It will be nice to have data on this, but it looks like we won't know until next year or the year after since a study has just been completed this month. 



#272 KBAnthis

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Posted 25 May 2019 - 07:35 PM

I am on day 3 now of the NMN powder sublingually and am imprssed so far. At the same time though I had ordered some other supplements. Specifically pine bark extract and grape seed extract, cold pressed organic borage seed oil, and an organic apple concentrate that is supposed to be pure rutin. Also while within a couple days adding in 10,000 IU daily of vitamin d3 and about 15 mg of k2 mk-4 and 350 mcg - k2 mk-7. Well my quality of life is so much higher now that I hopefully I do not have to stop taking any of them. I had been taking pine bark before but the combo of grape seed and pine bark is a big difference, in cognition alone improved from the OPCs. Also I just got some trans- resveratrol and had been on  a large break from it. I switched brands to curease from bulk supplements and it is a big quality differnce. I have no affilation and not sure what higher quality if any is avilable out there of pure trans resveratrol. Well anyway I am loving the NMN, and have noticed allready what seems to be an increase in NAD in my whole body and also my brain. I have hestitated on the NAD+ powder and am thinking of trying it. Anyone have any reasons not to , or reasons why to. That is why I originally posted if anyone had an opinion on it compared to NMN sublingually , both NAD+ and NMN sublingually, or if they advise against it for any reason. I started the NMN in hopes of angiogenesis opening up blood vessels to some injuries I hope to heal faster. So far so good. I seem to be healing and have a higher quality of life, but it has only been 3 days. I read on alivebynature to take a couple days of a week from it, I may try 7 days straight though to see what happens, and since David Sinclair has not said he takes a break from it. I can see why people would hesitate though since lack of clinical data. I had been eating mushrooms to prevent angiogenesis to not get any fatter, but now realized maybe I was hindering my healing and have since stopped eating them. 

Edit: I also added Nitrosigine but have not included it everyday. I have been doing some fasting is why.


Edited by KBAnthis, 25 May 2019 - 07:36 PM.

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#273 able

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Posted 25 May 2019 - 08:46 PM

It will be nice to have data on this, but it looks like we won't know until next year or the year after since a study has just been completed this month. 

 

 

What study is that?  Something on intranasal NAD+ in humans?

 

Or are you talking about NMN?  



#274 bluemoon

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Posted 25 May 2019 - 11:05 PM

 
ChromaDex to Assess the Effects of TRU NIAGEN on Cognitive Function, Mood and Sleep in Older Adults
 
Midwest Center for Metabolic and Cardiovascular Research
(participants n=40)
Dose: 300mg, 1,000mg & placebo
 
to be completed May 2019
---------------------------------------------------------------------
 
Mayo Clinic; University of Minnesota – Clinical and Translational Science Institute; Thorne Research Inc.
(participants n=48)
Dose: 750mg & placebo
 
to be complete June 2020
 
------------------------------------------------------------------
 
The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition
 
The University of Texas Health Science Center at San Antonio; University of Texas; South Texas Veterans Health Care System
(participants n=26)
Dose: 250mg titrated to 1g/day & placebo
 
to be complete December 2020
----------------------------------------------------------------


#275 able

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Posted 26 May 2019 - 03:45 AM

Ah, gotcha.   

 

It will certainly be interesting to get the results from the Chromadex study, but I don't know if a study on NR capsules will tell us much about the effect of intranasal NAD+.

 

For instance, this study showed intranasal NAD+ totally protected from brain injury, while injection of the same quantity of NAD+ did not.  (Intranasal Nicotinamide was also ineffective)

 

Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide

 

 Intranasal NAD+ bypasses the Blood brain barrier and restores NAD+, while injection does not. 

 

If  intranasal is  able to reach the brain so much more  than even injection, it seems unlikely NR capsules would compare at all.

 

 

 


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#276 KBAnthis

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Posted 26 May 2019 - 03:58 PM

Able are you taking the NAD+ sublingually? How does it compare to the NMN sublingual, noticeable difference? I am interested in a nasal spray application of NAD+ and may have to give it a try. 



#277 able

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Posted 28 May 2019 - 04:55 PM

Able are you taking the NAD+ sublingually? How does it compare to the NMN sublingual, noticeable difference? I am interested in a nasal spray application of NAD+ and may have to give it a try. 

 

Yes, I take the powder sublingual, and find the NAD+ is much more stimulative for overall energy and positive feelings.  

 

I personally don't get the same rush from the spray that my dad does, but after reading more of the positive effects  it has in research for alzheimers, parkinsons and such, I've decided to add it to my routine as preventative.



#278 KBAnthis

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Posted 28 May 2019 - 05:18 PM

Able, how much do you take a day of the NAD+ , I wish there was more information aviable , I would like to heal up some injuries and am considering adding it to days where I nourish after fasting. How much sublingual  powder and nasal sprays have you had success with?



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#279 able

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Posted 29 May 2019 - 05:58 PM

I've "had success" from taking around 1 gram of sublingual NMN over the last year, with improved strength and endurance.

 

Over the last few months I've switched to NAD+ most of the time, as I find it more stimulative.  I take 250 mg before my coffee, and another 250 mg before I leave the house.

 

I take more NAD+ or NMN before and after my HIIT 3 times a week.

 

I do continue to take NMN occassionaly, so I have no idea if the NAD+ has the same benefits for strength and endurance that I experienced with NMN, but I do like the rush from NAD+ more.

 

 

My dad is the one that had great response from the NAD+ spray - I can't tell much myself.  He tries to take 2-4 blasts several times a day, and goes thru a bottle in about a week.

 


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