Phoebus:
I haven't done the math but per mg nicotinamide is about 1/10 the price of NR/NMN
It also raises NAD+ although exactly how much and how it compares to NR/NMN I cant say.
https://www.ncbi.nlm...pubmed/10566977
but you could take 3x the amount compared to NR/NMN and it would still be cheaper. So really why bother with NR/NMN at all and just stick to nicotinamide?
Pirateer:
Could you take Nicotinamide (NAM) sublingually and get the same benefit you do with sublingual NMN/NR/ABNs new NAD powder?
Phoebus:
no
So you've changed your mind and now believe that NAM doesn't raise NAD+ despite being cheaper? Why the change of mind?
There is no doubt that NAM raises NAD+ in the liver. In fact in the Brenner study, per mg, it elevates NAD+ slightly more than NR. Thats because as Liu show, most NR and NMN get digested to NAM in the stomach, or end up as NAM before exiting the liver.
But it is also clear that NR has some different effects than NAM. In studies that show a difference, NR is more effective than NAM. I don't recall ever seeing a study that shows NAM working "better" than NR or NMN. There might be some, but NR and NMN do seem to be more effective. It's likely that some small % of NR/NMN supplements do make it through the liver without digestion, which is what makes it more effective than NAM.
As for taking NAM sublingual - whats the point? The reason for taking sublingual NR or NMN is to get them directly to the bloodstream and avoid them being digested to NAM. Increasing the portion that reaches the bloodstream without being digested to NAM is the goal.
Sublingual NAM might also avoid the stomach/liver, and go direct to the blood more quickly, but hard to imagine that being much benefit over swallowing NAM capsules.
Edited by able, 28 October 2018 - 08:44 PM.