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How are drugs absorbed & what could be reasons for why they aren't working for me?

pharmacology pharmacogenetic pharmacokinetics

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#31 farshad

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Posted 18 June 2019 - 01:36 AM

Pomegranate (Ellagic Acid)


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#32 farshad

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Posted 18 June 2019 - 04:41 PM

Gut microbes can eat our medication (And IMO possibly topical, sublingual etc since bactera is everywhere and can build up more depending on the person health state) https://chemistry.ha...-our-medication


Edited by farshad, 18 June 2019 - 04:44 PM.

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#33 farshad

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Posted 24 June 2019 - 01:45 PM

IODINE HIGH DOSE! WORKS.


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#34 farshad

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Posted 29 June 2019 - 12:53 AM

can ashwagandha, forskolin and bacopa heal the thyroid?

https://thyroidadvis...pplements-2019/


Edited by farshad, 29 June 2019 - 01:36 AM.


#35 farshad

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Posted 08 July 2019 - 08:55 PM

. Interestingly, recent reports have associated inflam- mation response with a decreased CYP2C19 activity in pa- tients with severe inflammatory disease. The decrease in drug metabolism can be up to 70% and is mediated by proin- flammatory cytokines (Vet et al., 2011). Thus, independent of metabolic genotype, systematic inflammation associated with SCD pain may downregulate CYP2C19 enzyme expression in SCD patients and lead to ''acquired'' PM status in patients either with homozygous (*1/*1) or heterozygous (*1/*2) ge- notype. ...

 

gonna supplement with butyrate in hopes of it healing my gut.


Edited by farshad, 08 July 2019 - 08:55 PM.


#36 farshad

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Posted 12 July 2019 - 12:20 AM

 

DMSO is a potent transdermal carrier and a solvent. It carries many things through the skin.

Maybe DMSO can help me absorb drugs...

 

Anyway gonna do a trail on  7 keto dhea since it is rapidly absorbed orally and 7-keto restored T3, T4, and immune cell levels to normal and is used for cell metabolism and by the brain.



#37 farshad

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Posted 13 July 2019 - 12:23 AM

gonna try eye drops (Ocular) anti inflammatory drugs etc since they bypass the BBB

https://en.wikipedia..._administration


Edited by farshad, 13 July 2019 - 12:24 AM.


#38 farshad

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Posted 13 July 2019 - 01:25 AM

then a pill is swallowed, it passes through your GI tract and gets absorbed in your intestines (an exception would be aspirin, which is absorbed in the stomach)

 

https://academic.oup.../1157/2896318  CYP enzymes

brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans:

 

btw https://en.wikipedia...wiki/Diclofenac exists as eye drops

 

hmm...https://en.wikipedia...ol#Pharmacology

 

https://en.wikipedia...Mucous_membrane

Niacin[2]:876 and vitamin A are essential nutrients that help maintain mucous membranes.[8] It also plays a role in absorbing and transforming nutrients.[2]:5,813 Mucous membranes also protect the body from itself; for instance mucosa in the stomach protects it from stomach acid,[


Edited by farshad, 13 July 2019 - 01:56 AM.


#39 farshad

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Posted 13 July 2019 - 10:08 AM

Fat-Soluble Vitamins: A, D, E, and K

 

vitamin a (Retino) eyedrops or its precursor Beta-carotene


Edited by farshad, 13 July 2019 - 10:10 AM.


#40 farshad

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Posted 14 July 2019 - 03:33 PM

does the spinal cord transport the drugs everywhere?



#41 farshad

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Posted 14 July 2019 - 04:29 PM

Stress ulcer https://www.ncbi.nlm...v/pubmed/797497

Delayed drug absorption due to altered gastric emptying usually results in therapeutic failure, especially if the drug has a short biological half-life. At present it is not possible to predict accurately the magnitude and clinical relevance of all drug absorption interactions.

 

Thus factors influencing the rate of gastric emptying may alter the rate of absorption of most if not all orally administered drugs. Food, hormones, posture, peritoneal irritation, severe pain, gastric ulcer, diabetes and other metabolic diseases. In most instances, increasing the rate of gastric emptying and gastro-intestinal motility increases the rate of absorption of a drug but, for digoxin and riboflavin, increased gastrointestinal motility is associated with a decrease in the rate of absorption

 

https://www.mayoclin...nt/drc-20355792

 

iv injection (progesterone)  or ulcers but via injection since oral wouldn´t work perhaps as good? 

 

https://www.nhs.uk/c...lcer/treatment/

 

https://en.wikipedia.org/wiki/Ulcer


Edited by farshad, 14 July 2019 - 04:48 PM.


#42 farshad

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Posted 14 July 2019 - 07:59 PM

https://en.wikipedia.../wiki/Gastritis

 

Impaired acid secretion may affect drug absorption and may be consequent to corporal Helicobacter pylori-gastritis, which may affect the absorption of orally administered drugs.

 

 

https://www.ncbi.nlm...pubmed/19053985

https://www.ncbi.nlm...les/PMC4130840/

 

gonna try antibiotics..oral


Edited by farshad, 14 July 2019 - 08:05 PM.


#43 farshad

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Posted 14 July 2019 - 09:33 PM

Chronic release of CRF and ACTH is believed to be directly or indirectly involved in many of the harmful physiological effects of chronic stress, such as e diabetes mellitus,  stomach ulcers



#44 farshad

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Posted 15 July 2019 - 02:22 PM



#45 farshad

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Posted 15 July 2019 - 05:56 PM

Role of transport proteins in drug absorption, distribution and excretion.

#46 farshad

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Posted 16 July 2019 - 11:23 PM

Diuretics , nicotinic acid(flush kind), Olive Oil,dandelion, uridine, dextrose(glucose),COQ10 (as CoQsol-CF)

 

https://www.reddit.c...e_drug_effects/

https://www.reddit.c...stric_emptying/

 

https://selfhacked.c..._for_Your_Liver

 

Hydrolyzed whey protein is produced when hot acid and/or enzymes break down whey proteins into smaller more quickly and easily digestible proteinThis predigested protein may enhance muscle protein synthesis [60].


Edited by farshad, 16 July 2019 - 11:25 PM.

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#47 farshad

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Posted 18 July 2019 - 03:52 PM

hmm Niacin high dose (as nicotinic acid) works I got the flush effect, but when I tried b complex before no effect. I guess I need to try b vitamins individually and high dosage...

 

Found this about niacin: Niacin is one of the most stable of the B vitamins. It is resistant to the effects of heat, light, air, acid, and alkali. A white crystalline substance that is soluble in both water and alcohol, niacin and niacinamide are both readily absorbed from the small intestine. Small amounts may be stored in the liver, but most of the excess is excreted in the urine.


Edited by farshad, 18 July 2019 - 04:16 PM.

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#48 farshad

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Posted 20 July 2019 - 07:54 PM

 

 

When L-ornithine and L-aspartate are given in combination, they are called LOLA. This combination is commonly used to manage the symptoms of hepatic encephalopathy, though it is probably only effective for chronic liver disease and not acute liver disease 

 


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#49 farshad

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Posted 22 July 2019 - 02:26 AM

https://selfhacked.c...log/phosphorus/


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#50 farshad

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Posted 23 July 2019 - 10:30 AM

https://en.wikipedia...ntrinsic_factor

 

 

for B12 to be absorbed into our system requires attachment to a molecule called intrinsic factor. This molecule is produced by the same cells as HCl in the stomach lining. Side note: with chronic stress and/or chronic use of acid reducers, production of I.F. also drops. I am not aware of any other vitamin that requires a carrier, but as one of the largest vitamins I suppose it makes sense that it uses a "motorized scooter" of sorts to help it get around. 

 



#51 farshad

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Posted 24 July 2019 - 02:33 AM

https://www.reddit.c...are_up_against/



#52 farshad

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Posted 24 July 2019 - 10:20 PM

https://www.avogel.c...eted-by-stress/

 

 

 

Vitamin C also acts as an antioxidant in human cells by neutralizing harmful compounds. It protects the cells (by reducing oxidative stress) and is responsible for a host of health benefits, boosting metabolism and nutrient absorptionStress can have a number of physical effects on the body: it can slow down your digestive processes, increase inflammation and inhibit your sleep patterns. What most people don’t realise though, is that stress can also affect how you absorb and store certain nutrients leading to a whole host of additional unpleasant symptoms such as fatigue, low mood and muscle pain. That’s why today I’m going to take a look at how stress can deplete your stores of nutrients, which nutrients are most commonly affected and how you can go about boosting your intake of these.
 
 

 


Edited by farshad, 24 July 2019 - 10:25 PM.


#53 farshad

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Posted 25 July 2019 - 12:08 AM

 

Listen to your gut. Rectify a digestion problem before it becomes chronic. Whether you suffer from acid reflux, constipation, gas, bloating or indigestion, the food you eat isn’t being properly processed. This reduces your ability to absorb nutrients from it, and can result in long-term, serious health issues.

Did you know that it’s impossible to digest food without magnesium? A deficiency contributes to your digestive trouble.

Without magnesium, your body can’t perform the “mechanics” of digestion, make hydrochloric acid (stomach acid), make digesting enzymes for carbs, proteins and fats, and repair and protect your digestive organs (esophagus, stomach, intestines, pancreas, colon).

As soon as you put food into your mouth, magnesium comes into play. It helps to make enzymes in yoursaliva that break food down into smaller parts, helping the entire digestive process. The hormones that tell your stomach to produce digestive acid need magnesium to be made; without it, you can’t digest food. After your stomach, food goes into your intestines, where more enzymes made by the pancreas break it down small enough to be absorbed as nutrients. The pancreas must have magnesium to make these vitalenzymes. Magnesium also keeps the pancreas healthy, helping to prevent pancreatitis and pancreatic cancer.

Common conditions including acid reflux (heartburn) and GERD are not linked to excess stomach acid, as many people think, but low stomach acid. These conditions, too, are affected by magnesium deficiency. How? GERD and acid reflux are caused by a malfunctioning esophageal sphincter. This may happen due to a bacterial overgrowth that occurs when there is too little stomach acid. Magnesium aids stomach acid production that reduces bad bacteria in the gut.

Slow flow? Of all of these issues, poor elimination (constipation) is the most common final result of poor digestion. One symptom of magnesium deficiency is constipation. According to the American Gastroenterological Association, 16% of adults (including one-third of people over 60) are chronically constipated, meaning they have three or fewer bowel movements per week. Learn about the common causes of constipation and what you can do it about it!

https://www.ncbi.nlm.../pubmed/7955775

 


Edited by farshad, 25 July 2019 - 12:10 AM.


#54 farshad

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Posted 26 July 2019 - 08:23 AM

https://docdro.id/0u2vmzc

 Blood levels are dependant on the rate of excretion via the kidneys... this means that everything from hydration to excersise to salt intake can influence blood values

 

Magnesium deficiency causes poor absorption from the intestines,


Edited by farshad, 26 July 2019 - 08:27 AM.


#55 farshad

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Posted 26 July 2019 - 09:38 AM

The metabolism can be stimulated with natural, high-quality, organic, cold pressed coconut oil due to this oil containing triglycerides, which are simply called MCT and which when found in nature are only contained in very few oils.

These fats are not absorbed by the body and therefore do not behave like fats. They also lower cholesterol levels, and they also stimulate the metabolism, they deliver high quality energy to the body and promote the absorption of calcium and magnesium.

The avocado contains not only calories and fruit fat, but also a lot of fibre, as well as the important vitamin C, iron, folic acid, potassium, copper and magnesium, which are extremely important for the body and organism.

The pseudo-grains Amaranth and Quinoa (staple foods in South America for centuries) provide the perfect combination of protein with tryptophan and carbohydrates. If taken on an empty stomach (important!), their fine fibrous materials form an aqueous solution with plenty of liquid immediately after ingestion, which is let through from the stomach unhindered into the small intestine. Due to the low digestive work and rapid absorption, the ingredients soon end up in the blood. It contains an abundance of amino acids as well as a balanced mixture of carbohydrates of different lengths. The latter attract the transport hormone insulin, which not only transports glucose into the cells, but also the amino acids that have just arrived in the blood stream into the mitochondria (power plants) of the skeletal muscles. In this way, all tangible amino acids are used for energy production – with only one exception, namely the amino acid tryptophan, which does not fit into the absorption pattern of the skeletal muscles. A prerequisite for this is the state of being sober, so that the muscles have a need for energy. all vital substances and enzymes are original and active and can therefore be used very well by the body. Quinoa and amaranth are the most iron- and magnesium-rich foods in the category of holistic and wholesome cereal products. Amaranth is also the uncrowned calcium king in this group and provides almost twice as much of the bone-strengthening material as cow's milk.

 



#56 farshad

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Posted 26 July 2019 - 11:35 PM

First, the production of stress hormones and neurotransmitters consumes a big chunk of these nutrients’ reserves.

Then, because stress largely shuts down the digestive system, less of them gets absorbed from the food you eat.

Consequently, your supply of anti-stress vitamins and minerals is decreased … and your tolerance to stress is lowered.

Inflammation shuts down energy production in brain cells, contributing to stress, anxiety, brain fog, mental fatigue, and depression

Magnesium has been called “the master mineral” for the role it plays in over 600 metabolic functions in the body. (42)

It’s also been called “nature’s Valium” because it’s so good at combating stress and making you feel more relaxed.

There is a direct correlation between low magnesium levels and how easily you get stressed out.

The link between magnesium and anxiety is so strong that researchers can induce anxiety in lab animals at will by depriving them of magnesium. (43)

Stress causes magnesium to be excreted during urination, thereby depleting body stores. (44)

One way magnesium neutralizes stress is by binding to and stimulating GABA receptors in the brain



#57 farshad

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Posted 27 July 2019 - 03:44 AM

How stress snatches magnesium

Magnesium is essential to help our bodies function properly, but stress can zap your stores. Here’s what to do about it and how magnesium can help with stress management.

Magnesium plays a crucial role in maintaining our central nervous system, including helping our cells produce and use energy. In fact, it’s so important, researchers refer to the mineral as a ‘neuroprotector’.

Magnesium vs stress 

The trouble is stress can increase the amount of magnesium we lose from our body (in urine), leading to a magnesium deficiency. In turn, that deficiency enhances our response to stress – we can get stuck in a cycle of feeling stressed, losing magnesium, reacting even more to stress, losing more magnesium, and so on.

When you have low magnesium levels, the point at which your adrenal glands produce the stress hormones adrenaline and cortisol is also lower. This means even small stresses, like the ear-jangling noise of a building site, can trigger a huge reaction, flooding your nervous system with hormones and further depleting your magnesium levels.

 



#58 farshad

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Posted 28 July 2019 - 01:33 AM

Ionized (or charged) drugs are not absorbed as efficiently as un-ionized drugs are. Practically speaking, this means that if taken orally, a drug that is a weak acid will be absorbed primarily in the acidic environment; whereas, a drug that is a weak base will be absorbed in the alkaline environment small intestines.

https://www.pharmaco...drug-absorption



#59 farshad

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Posted 28 July 2019 - 03:17 AM

Importance in drug binding

An article[56] investigating the structural basis of interactions between clinically relevant antibiotics and the 50S ribosome appeared in Nature in October 2001. High-resolution X-ray crystallography established that these antibiotics associate only with the 23S rRNA of a ribosomal subunit, and no interactions are formed with a subunit's protein portion. The article stresses that the results show "the importance of putative Mg2+(magnesium) ions for the binding of some drugs".

 

Magnesium is required for the production of ATP (the main source of energy in our cells) [3], and the production of DNA, RNA, and proteins [4].

Magnesium plays an important role in cell-to-cell communication [

 

To transport the drugs across the body^^^^


Edited by farshad, 28 July 2019 - 03:19 AM.


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#60 farshad

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Posted 29 July 2019 - 09:09 AM

Mg2+ (magnesium) for Dna repair enzymes, and Zn2+ (zinc) for Dna polymerase







Also tagged with one or more of these keywords: pharmacology, pharmacogenetic, pharmacokinetics

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