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How are drugs absorbed & what could be reasons for why they aren't working for me?

pharmacology pharmacogenetic pharmacokinetics

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#1 farshad

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Posted 05 May 2019 - 02:32 PM


hello let me give you some of my background. I have suffered from social anxiety whole my life and it wasn't until I was around the age of 18 I started researching and looking into why and perhaps drugs that could help me. Anyway it took me a long time to figure things out because I started with zero experience and knowledge, on top of that im not the brightest guy im kinda slow but I have very good reasons for that which I won't get into. Anyway on my journey was I was experimenting with drugs and supplements I just bought whatever without even looking into the science and wasted a lot of money. it was not until I was around age of 19 that I looked into biology and stuff and, anyway to make a long story short I realize my anxiety is caused by excess CRHR1. To make the story even shorter I have found a drug or two that might help (valproic acid, lithium carbonate) in high dosages as they decrease this protein CRHR1 in the brain. but the thing is, when I take any drug or supplements they have zero effect on me, they just pass trough like I took nothing. For example rhodiola rosea used to have an stimulating effect on me, not anymore. Memantine effect was very strong and obvious but now nothing. Im not sure what the cause is but I can tell you, the CRHR1 excess has caused a tremendous stress and anxiety on my mind/body and my health has suffered very much, I have fatigue that you cannot imagine and I dont think many people would survive being in the same place i am. Anyhow(I love this word), what do you guys think could be the cause for this? it's not a tolerance thing because I dont abuse them and i have tried new drugs that i never taken before and yet no effect for example tianeptine should have an obvious effect im certain. My question is simple, given what I have told you so far, stress > health downgrade > fatigue > drugs not working, what could you make of this do any information so far, does it hold any merit? I just want drugs and supplements to work again so I can fix my social anxiety with the two latter drugs i've mentioned. No route of administration have an effect on me and I have tried many (topical,orally,sublingual,rectum,snorting). What I have not tried is injecting which is what I will do if nothing else works or if you guys have no advice for me. But first I wanna heal my body using Ubiquinol (Active COQ10) becuase im taking it orally and it has no effect so I will find a way to inject it directly into my bloodstream. I have ordered some probiotics and l-glutamine because they apparantly help with the GI tract were drugs are absorbed orally but then again wouldn't this be pointless because other ROA have not worked for me which bypass the gastrointestinal tract. https://www.ncbi.nlm...les/PMC3914806/ this study says probiotics when taken with a drug increased the drug by 43%. 

 

Other possibly causes:

 

-Inflammation

-Low mithochondria (your body needs energy to transport the drugs)

- free radicals (bad bacteria kills the drug before it can have an effect) OR the good bacteria are too busy fighting bad bacteria to use the drug

- Low pottasium or sodium? (energy for ATP)

 

here is a good video maybe give you guys some idea:

 

more info on my other threads:

https://www.reddit.c...on_with_severe/

https://www.reddit.c...ase_absorption/

https://www.reddit.c...lammatory_drug/


Edited by farshad, 05 May 2019 - 02:38 PM.


#2 farshad

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Posted 06 May 2019 - 01:24 AM

''Most of epithelial surfaces of human body such as the skin and the mucosa (sublingual) (and the nose snorting etc) , eyes  are colonized by a vast number of microorganisms, which are collectively known as microbiota or microbiome. ''  Use Probiotics To reduce the development of drug-resistant bacteria (bad bacteria/free radicals etc) and maintain the effectiveness of the drugs.

 

http://dmd.aspetjour...ontent/46/2/122

 

https://www.nature.c...working-1.22109

 

 

https://hummkombucha...d-bad-bacteria/ Stress etc >> bad bacteria takeover / free radicals etc >> health damage > cycle continutes as health detoriates (spelling?) >> bad bacteria everywhere in the body IE Skin, nose, eyes etc so no Route of administration when taking drugs work they just turn into toxins etc 

 


Edited by farshad, 06 May 2019 - 01:32 AM.


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#3 xEva

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Posted 06 May 2019 - 01:59 AM

farshad, I've seen your many posts and I feel for you. clearly, you have some unusual issues, which are hard to deal with. But. Why won't you see specialists? In your place, here is what I'd do:

 

1. do your genome (cheap 23andme) and pay a specialist to analyze your neurotransmitters, hormones, main metabolic enzymes.

 

2. consult endocrinologist and run tests

 

3. consult psychiatrist and run tests

 

Or, alternatively, you can enroll in a med school and specialize in psychiatry or endocrinology. Otherwise, on this forum and others, you are learning, without a doubt, but mostly it is grappling in the dark. You may stumble upon the solution by luck, but then again maybe not.

 

 

PS________

oops! you're in the US now -? You used to be in Europe! Oh well, never mind then, you probably don't have adequate or affordable med care, which means that indeed, you're on your on. Sorry about that.

 


Edited by xEva, 06 May 2019 - 02:11 AM.

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#4 farshad

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Posted 06 May 2019 - 02:09 AM

No offence but I don't need or want your sympathy or anyone elses, I know what im doing even tho it might not look like so. I try not to post as much because I don't wanna spam so it's surprising you say you've seen a lot of my posts.


Edited by farshad, 06 May 2019 - 02:27 AM.

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#5 farshad

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Posted 06 May 2019 - 05:04 PM

wow the only supplement that has had an profound effect is Probiotics, I can tell if I take it for a period of time I will get better. But I only took 50 billion (10x5billion capsules) which is low considering how many bacteria we have in our body, in the trillions. I ordered a different supplement which has 100 billion per capsule and I willl take 1 trillion. Probiotics are no joke they're the real thing!


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#6 farshad

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Posted 07 May 2019 - 02:05 AM



#7 farshad

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Posted 07 May 2019 - 11:20 PM

 

https://drugabuse.co.../liver-disease/

 

milk thistle has any1 tried it for liver function


Edited by farshad, 07 May 2019 - 11:25 PM.


#8 farshad

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Posted 08 May 2019 - 12:31 AM

https://www.livescie...body-nigms.html



#9 farshad

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Posted 08 May 2019 - 06:35 PM

maybe drugs metabolized by certain enzymes only like cyp3a4 can help me

https://upload.wikim...thway_WP229.png

https://www.reddit.c...tabolize_drugs/


Edited by farshad, 08 May 2019 - 07:18 PM.


#10 farshad

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Posted 08 May 2019 - 08:13 PM

The body's immediate response is to release chemicals, called “stress hormones,” which are used by the body to make energy. ... The continuous increase in stresshormones can also result in suppression of the immune system's white blood cells, leading to an increased risk of infections.



#11 farshad

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Posted 12 May 2019 - 06:45 PM

https://www.msdmanua...ug-distribution



#12 farshad

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Posted 13 May 2019 - 09:42 PM

https://en.wikipedia...Allostatic_load

 

Allostatic load is "the wear and tear on the body" which accumulates as an individual is exposed to repeated or chronic stress. The term was coined by McEwen and Stellar in 1993. It represents the physiological consequences of chronic exposure to fluctuating or heightened neural or neuroendocrineresponse which results from repeated or prolonged chronic stress.

 

https://en.wikipedia...i/Myxedema_coma

 

https://en.wikipedia...i/Levothyroxine

https://en.wikipedia...riiodothyronine



#13 farshad

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Posted 15 May 2019 - 10:20 AM

BINGO!!! Is Coconut oil (the MCT content) the answer to my problem?

 

MCTs passively diffuse from the GI tract to the portal system (longer fatty acids are absorbed into the lymphatic system) without requirement for modification like long-chain fatty acids or very-long-chain fatty acids. In addition, MCTs do not require bile salts for digestion. Patients who have malnutritionmalabsorption or particular fatty-acid metabolism disorders are treated with MCTs because MCTs do not require energy for absorption, use, or storage.

 

https://en.wikipedia...in_triglyceride

 

https://en.wikipedia.../wiki/Dysbiosis

 

https://www.reddit.com/r/Microbiome/


Edited by farshad, 15 May 2019 - 10:50 AM.


#14 farshad

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Posted 16 May 2019 - 11:25 AM

https://www.nutrisha...id-supplements/

 

https://www.healthli...ds-101#section3

 

 

long chain fatty acids (OMEGA-3 etc) are shunted into and stored in adipose (fat) tissue. This is nature’s way of keeping energy stores in reserve without the fats needing to go through the liver process again.

short-chain-fatty-acids (butyrate) & medium-chain (MCT OIL comes from Coconut oil) skip this process because they bypass the lymph system, your body does not store these medium-chain fatty acids in adipose (fat) tissue to use later when energy is low.

 
This direct transport to your liver is how they are able to supply energy more rapidly (similar to carbohydrates).

Edited by farshad, 16 May 2019 - 11:38 AM.


#15 farshad

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Posted 17 May 2019 - 11:47 AM

https://en.wikipedia.org/wiki/Ketosis


Edited by farshad, 17 May 2019 - 11:48 AM.


#16 farshad

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Posted 19 May 2019 - 03:12 PM

https://en.wikipedia...bioavailability



#17 farshad

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Posted Yesterday, 01:55 PM

https://selfhacked.c...le-supplements/

TUDCA, milk thistle (LIVER)

 

Carnitor - an L-carnitine supplement that has shown to improve the body's metabolism in individuals with low L-carnitine levels. It is only useful for Specific fatty-acid metabolism disease.

 

 


Edited by farshad, Yesterday, 02:28 PM.

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#18 farshad

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Posted Today, 10:35 AM

PURE MCT SOFTGELS IS WAY BETTER THAN COCONUT OIL

 

KRILL OIL TOO IS GOOD


Edited by farshad, Today, 10:35 AM.

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