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How are drugs absorbed & what could be reasons for why they aren't working for me?

pharmacology pharmacogenetic pharmacokinetics

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#61 farshad

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Posted 31 July 2019 - 06:28 PM

http://www.magnesium...agnesium-works/

Our metabolism needs to occur at a certain speed to stay alive. But we don’t have the liberty of turning the body into a raging furnace to speed up these reactions (not without damaging many things). That’s where enzymes come in.

Enzymes are bits of protein that catalyze and regulate almost all metabolic reactions. As catalysts, they reduce the energy needed to spark a chemical reaction and speed up reactions. Without enzymes, reactions that would normally take milliseconds might take hours or days.

Possibly drug absorption too? Since magnesium is a cofactor to these enzymes. And if you lack magnesium you have less of these enzymes so the drug never gets absorbed and before it does it is already excreted.



#62 farshad

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Posted 04 August 2019 - 05:42 PM

Is there anything like memantine with long half life (memantine is 3 days), and large mean volume of distribution (about 700L in the average 70kg male), which memantine has. Together with high protein binding? which memantine lacks(only 50%, need 90%+), but still has an effect on me in larger doses...


Edited by farshad, 04 August 2019 - 05:42 PM.


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#63 farshad

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Posted 16 August 2019 - 08:30 PM

With age(or stress?), the likelihood increases that a person produces less gastric intrinsic factor to bind B12, allowing it to be absorbed in the intestine. It's possible you have decreased energy because you're not producing enough GIF.

 

I imagine it depends what was the cause of the deficiency. I think mine was due to stress and anxiety causing a chronic upset stomach which hindered the absorption.


Edited by farshad, 16 August 2019 - 08:56 PM.


#64 farshad

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Posted 18 August 2019 - 11:33 PM

Gut microbes can eat our medication, suggests a new study using the Human Microbiome Project, the first concrete example of how one species of bacteria consumes levodopa, the primary treatment for Parkinson’s disease, which could reveal more about how the microbiome impacts our health.https://chemistry.ha...-our-medication



#65 joesixpack

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Posted 19 August 2019 - 04:11 AM

wow the only supplement that has had an profound effect is Probiotics, I can tell if I take it for a period of time I will get better. But I only took 50 billion (10x5billion capsules) which is low considering how many bacteria we have in our body, in the trillions. I ordered a different supplement which has 100 billion per capsule and I willl take 1 trillion. Probiotics are no joke they're the real thing!

If it works, use it.



#66 farshad

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Posted 19 August 2019 - 01:49 PM

I feel like powders work better than capsules etc


Edited by farshad, 19 August 2019 - 01:49 PM.


#67 farshad

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Posted 25 August 2019 - 12:32 PM

One of the most effective ways to improve your magnesium levels is to combine a healthy diet with transdermal magnesium.
Many of the factors which contribute to low magnesiumstores are caused by inefficiencies of the GI tract. By delivering magnesium through the skin directly to the cells,topical magnesium products bypass many of the problems associated with low magnesium absorption.


#68 farshad

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Posted 06 September 2019 - 01:27 PM

http://www.youtube.c...h?v=YtkCYhq3Rtc Now you have to test for ACTIVE-b12 ? 

 

 

If you have a GI disorder or some other absorption issue oral won't work, you would need injection (IM).
 

Edited by farshad, 06 September 2019 - 01:55 PM.


#69 farshad

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Posted 08 September 2019 - 08:55 AM

I know it, if stress depletes your body out magnesium and b12 etc and since they're critical for enzyme DNA development and enzymes that break down and convert / use drugs you ingest, could it be possible that stress depletes them so much your body don't make enough of these so the drugs just pass trough you like nothing?



#70 farshad

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Posted 08 September 2019 - 10:09 AM

low ph count?



#71 farshad

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Posted 12 September 2019 - 08:36 PM

 

Vitamin B12 is absorbed and processed by the body differently. It has two parts to the process, one of which requires a thing called an "intrinsic factor." Some people don't produce this intrinsic factor - it's a condition called "pernicious anemia." This means they can't absorb vitamin B12 properly from food or oral supplements. So it has to be injected, or inhaled as a spray so it can absorb through their nose.

 
 

 

Has anyone inhaled b12 ? does that even work? Or should I go for injection/shots? 

https://www.amazon.c...s/dp/B01KB3EM9U

 

stress depletes intrinsic factor? which type should one also inject?

 

 

 

Malabsorption-related[edit]

The changes in the bowel make it less able to absorb nutrients, minerals, and the fat-soluble vitamins A, D, E, and K.[18][43]

https://en.wikipedia...Coeliac_disease


Edited by farshad, 12 September 2019 - 09:31 PM.


#72 farshad

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Posted 16 September 2019 - 04:06 PM

Dysfunction of blood vessels



#73 DaveX

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Posted 16 September 2019 - 05:20 PM

"To make the story even shorter I have found a drug or two that might help (valproic acid, lithium carbonate) in high dosages as they decrease this protein CRHR1 in the brain. but the thing is, when I take any drug or supplements they have zero effect on me, they just pass trough like I took nothing. For example rhodiola rosea used to have an stimulating effect on me, not anymore"

I don't think any of these things are routinely stimulating, and lithium on the contrary is making slightly tired and blunting motivation. Rhodiola does nothing for 70% who've tried it... If you want stimulation, you'd be far better advised with just taking coffee - and never lithium. I feel fairly certain that obsessively focusing on CRHR1 alone is a bad idea and a waste of effort, let alone if you then change it with an exaggerated obsession about drug metabolism, based on these things alone which aren't even stimulating. It's a rabbit hole.
  • Ill informed x 1

#74 farshad

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Posted 16 September 2019 - 11:59 PM

"To make the story even shorter I have found a drug or two that might help (valproic acid, lithium carbonate) in high dosages as they decrease this protein CRHR1 in the brain. but the thing is, when I take any drug or supplements they have zero effect on me, they just pass trough like I took nothing. For example rhodiola rosea used to have an stimulating effect on me, not anymore"

I don't think any of these things are routinely stimulating, and lithium on the contrary is making slightly tired and blunting motivation. Rhodiola does nothing for 70% who've tried it... If you want stimulation, you'd be far better advised with just taking coffee - and never lithium. I feel fairly certain that obsessively focusing on CRHR1 alone is a bad idea and a waste of effort, let alone if you then change it with an exaggerated obsession about drug metabolism, based on these things alone which aren't even stimulating. It's a rabbit hole.

nice try, are you some sort of shill trying to get me off track? I am 100 percent sure about this, i would bet my life (not that it means much i guess since i wanna die anyway) that I have a crhr1 mutation and that due to stress from this mutation somehow drugs are unable to work because my health is in such poor condition, you have no idea how much pain i am in but i hide it well i dont like to show it to others.  I know I have excess CRHR1 levels in either my amygdala or hippocampus, I go more  towards my amygdala and specifically the basal region. 

Say most of the world population 99%  has 1000 million crhr1 protein cells (just an example)

then take me who maybe has 1500 million crhr1 protein cells in my amygdala

 

now it has shown that blocking crhr1 leads to a blunted stress response in studies. So regardless if I take therapy or do my best to try and not develop anxiety, the crhr1 protein in me being in excess and different from the rest of the humans, i will react much more to stressors, thus my brain will try to adapt and in doing so = more anxiety. its to the point that i dont even feel calm at my home. So, too much crhr1, means your brain tries to ''adapt'' too much to the environment which is bad. thats why when you block it you have blunted stress response = less need for adaptation = never learn the stressors

 

my point with the 1000 million crhr1 protein cells vs 1500 million was that, your brain will try to adapt to the majority of the humans who have different levels of crhr1 protein than yours (lesser), but you will never able to do so. which is why its even bad having too little crhr1 protein, because your brain cant adapt and learn and overcome the fear, and if you have too little crhr1 protein say 500 million and the rest of the world has 1000 million, you will still develop fears granted not as much as the person with excess but my point is its about having an balance and having the same levels as rest of humanity otherwise you will lead to downfall regardless because your brain is in a different activity/vibration.


Edited by farshad, 17 September 2019 - 12:05 AM.


#75 farshad

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Posted 19 September 2019 - 08:52 PM

I think I have this https://en.wikipedia.org/wiki/Prolapse or https://en.wikipedia.../wiki/Cirrhosis

 

not sure if it affects drug absorption?


Edited by farshad, 19 September 2019 - 08:53 PM.


#76 farshad

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Posted 19 September 2019 - 09:53 PM

https://www.reddit.c...157_to_correct/



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#77 farshad

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Posted Yesterday, 12:10 AM

Symptoms of mild Vitamin B3 deficiency include:

  • Indigestion
  • Poor circulation
  •  

https://en.wikipedia...iki/Indigestion







Also tagged with one or more of these keywords: pharmacology, pharmacogenetic, pharmacokinetics

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