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How are drugs absorbed & what could be reasons for why they aren't working for me?

pharmacology pharmacogenetic pharmacokinetics

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#61 farshad

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Posted 31 July 2019 - 06:28 PM

http://www.magnesium...agnesium-works/

Our metabolism needs to occur at a certain speed to stay alive. But we don’t have the liberty of turning the body into a raging furnace to speed up these reactions (not without damaging many things). That’s where enzymes come in.

Enzymes are bits of protein that catalyze and regulate almost all metabolic reactions. As catalysts, they reduce the energy needed to spark a chemical reaction and speed up reactions. Without enzymes, reactions that would normally take milliseconds might take hours or days.

Possibly drug absorption too? Since magnesium is a cofactor to these enzymes. And if you lack magnesium you have less of these enzymes so the drug never gets absorbed and before it does it is already excreted.



#62 farshad

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Posted 04 August 2019 - 05:42 PM

Is there anything like memantine with long half life (memantine is 3 days), and large mean volume of distribution (about 700L in the average 70kg male), which memantine has. Together with high protein binding? which memantine lacks(only 50%, need 90%+), but still has an effect on me in larger doses...


Edited by farshad, 04 August 2019 - 05:42 PM.


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#63 farshad

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Posted 16 August 2019 - 08:30 PM

With age(or stress?), the likelihood increases that a person produces less gastric intrinsic factor to bind B12, allowing it to be absorbed in the intestine. It's possible you have decreased energy because you're not producing enough GIF.

 

I imagine it depends what was the cause of the deficiency. I think mine was due to stress and anxiety causing a chronic upset stomach which hindered the absorption.


Edited by farshad, 16 August 2019 - 08:56 PM.


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#64 farshad

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Posted 18 August 2019 - 11:33 PM

Gut microbes can eat our medication, suggests a new study using the Human Microbiome Project, the first concrete example of how one species of bacteria consumes levodopa, the primary treatment for Parkinson’s disease, which could reveal more about how the microbiome impacts our health.https://chemistry.ha...-our-medication



#65 joesixpack

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Posted 19 August 2019 - 04:11 AM

wow the only supplement that has had an profound effect is Probiotics, I can tell if I take it for a period of time I will get better. But I only took 50 billion (10x5billion capsules) which is low considering how many bacteria we have in our body, in the trillions. I ordered a different supplement which has 100 billion per capsule and I willl take 1 trillion. Probiotics are no joke they're the real thing!

If it works, use it.



#66 farshad

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Posted 19 August 2019 - 01:49 PM

I feel like powders work better than capsules etc


Edited by farshad, 19 August 2019 - 01:49 PM.


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#67 farshad

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Posted 25 August 2019 - 12:32 PM

One of the most effective ways to improve your magnesium levels is to combine a healthy diet with transdermal magnesium.
Many of the factors which contribute to low magnesiumstores are caused by inefficiencies of the GI tract. By delivering magnesium through the skin directly to the cells,topical magnesium products bypass many of the problems associated with low magnesium absorption.


#68 farshad

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Posted 06 September 2019 - 01:27 PM

http://www.youtube.c...h?v=YtkCYhq3Rtc Now you have to test for ACTIVE-b12 ? 

 

 

If you have a GI disorder or some other absorption issue oral won't work, you would need injection (IM).
 

Edited by farshad, 06 September 2019 - 01:55 PM.


#69 farshad

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Posted 08 September 2019 - 08:55 AM

I know it, if stress depletes your body out magnesium and b12 etc and since they're critical for enzyme DNA development and enzymes that break down and convert / use drugs you ingest, could it be possible that stress depletes them so much your body don't make enough of these so the drugs just pass trough you like nothing?



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#70 farshad

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Posted 08 September 2019 - 10:09 AM

low ph count?



#71 farshad

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Posted 12 September 2019 - 08:36 PM

 

Vitamin B12 is absorbed and processed by the body differently. It has two parts to the process, one of which requires a thing called an "intrinsic factor." Some people don't produce this intrinsic factor - it's a condition called "pernicious anemia." This means they can't absorb vitamin B12 properly from food or oral supplements. So it has to be injected, or inhaled as a spray so it can absorb through their nose.

 
 

 

Has anyone inhaled b12 ? does that even work? Or should I go for injection/shots? 

https://www.amazon.c...s/dp/B01KB3EM9U

 

stress depletes intrinsic factor? which type should one also inject?

 

 

 

Malabsorption-related[edit]

The changes in the bowel make it less able to absorb nutrients, minerals, and the fat-soluble vitamins A, D, E, and K.[18][43]

https://en.wikipedia...Coeliac_disease


Edited by farshad, 12 September 2019 - 09:31 PM.


#72 farshad

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Posted 16 September 2019 - 04:06 PM

Dysfunction of blood vessels



#73 DaveX

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Posted 16 September 2019 - 05:20 PM

"To make the story even shorter I have found a drug or two that might help (valproic acid, lithium carbonate) in high dosages as they decrease this protein CRHR1 in the brain. but the thing is, when I take any drug or supplements they have zero effect on me, they just pass trough like I took nothing. For example rhodiola rosea used to have an stimulating effect on me, not anymore"

I don't think any of these things are routinely stimulating, and lithium on the contrary is making slightly tired and blunting motivation. Rhodiola does nothing for 70% who've tried it... If you want stimulation, you'd be far better advised with just taking coffee - and never lithium. I feel fairly certain that obsessively focusing on CRHR1 alone is a bad idea and a waste of effort, let alone if you then change it with an exaggerated obsession about drug metabolism, based on these things alone which aren't even stimulating. It's a rabbit hole.
  • Ill informed x 1

#74 farshad

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Posted 16 September 2019 - 11:59 PM

"To make the story even shorter I have found a drug or two that might help (valproic acid, lithium carbonate) in high dosages as they decrease this protein CRHR1 in the brain. but the thing is, when I take any drug or supplements they have zero effect on me, they just pass trough like I took nothing. For example rhodiola rosea used to have an stimulating effect on me, not anymore"

I don't think any of these things are routinely stimulating, and lithium on the contrary is making slightly tired and blunting motivation. Rhodiola does nothing for 70% who've tried it... If you want stimulation, you'd be far better advised with just taking coffee - and never lithium. I feel fairly certain that obsessively focusing on CRHR1 alone is a bad idea and a waste of effort, let alone if you then change it with an exaggerated obsession about drug metabolism, based on these things alone which aren't even stimulating. It's a rabbit hole.

nice try, are you some sort of shill trying to get me off track? I am 100 percent sure about this, i would bet my life (not that it means much i guess since i wanna die anyway) that I have a crhr1 mutation and that due to stress from this mutation somehow drugs are unable to work because my health is in such poor condition, you have no idea how much pain i am in but i hide it well i dont like to show it to others.  I know I have excess CRHR1 levels in either my amygdala or hippocampus, I go more  towards my amygdala and specifically the basal region. 

Say most of the world population 99%  has 1000 million crhr1 protein cells (just an example)

then take me who maybe has 1500 million crhr1 protein cells in my amygdala

 

now it has shown that blocking crhr1 leads to a blunted stress response in studies. So regardless if I take therapy or do my best to try and not develop anxiety, the crhr1 protein in me being in excess and different from the rest of the humans, i will react much more to stressors, thus my brain will try to adapt and in doing so = more anxiety. its to the point that i dont even feel calm at my home. So, too much crhr1, means your brain tries to ''adapt'' too much to the environment which is bad. thats why when you block it you have blunted stress response = less need for adaptation = never learn the stressors

 

my point with the 1000 million crhr1 protein cells vs 1500 million was that, your brain will try to adapt to the majority of the humans who have different levels of crhr1 protein than yours (lesser), but you will never able to do so. which is why its even bad having too little crhr1 protein, because your brain cant adapt and learn and overcome the fear, and if you have too little crhr1 protein say 500 million and the rest of the world has 1000 million, you will still develop fears granted not as much as the person with excess but my point is its about having an balance and having the same levels as rest of humanity otherwise you will lead to downfall regardless because your brain is in a different activity/vibration.


Edited by farshad, 17 September 2019 - 12:05 AM.

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#75 farshad

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Posted 19 September 2019 - 08:52 PM

I think I have this https://en.wikipedia.org/wiki/Prolapse or https://en.wikipedia.../wiki/Cirrhosis

 

not sure if it affects drug absorption?


Edited by farshad, 19 September 2019 - 08:53 PM.


#76 farshad

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Posted 19 September 2019 - 09:53 PM

https://www.reddit.c...157_to_correct/



#77 farshad

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Posted 20 September 2019 - 12:10 AM

Symptoms of mild Vitamin B3 deficiency include:

  • Indigestion
  • Poor circulation
  •  

https://en.wikipedia...iki/Indigestion



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#78 farshad

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Posted 21 September 2019 - 04:15 PM

All tissues in the body convert absorbed niacin into its main metabolically active form, the coenzyme nicotinamide adenine dinucleotide (NAD). More than 400 enzymes require NAD to catalyze reactions in the body, which is more than for any other vitamin-derived coenzyme [1]. 



#79 farshad

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Posted 24 September 2019 - 12:37 AM

Inflammation is the root cause of gut dysfunction caused by chronic stresschronic inflammation is a chief driver for nearly every disease on the planet, including obesity. It contributes to numerous gut problems including dysbiosis, or gut imbalances that lead to problems like leaky gut.

Chronic inflammation doesn't happen overnight, nor does reversing it, especially if you've been very inflamed for a long time. But by incorporating all (not just one—remember, there's no easy way out!) of these strategies, you will begin taming your inflammation and start seeing results in as little as two weeks. Once you've healed, you'll notice the symptoms that were nagging you, like unexplained fatigue and mental fog, will have disappeared or become unnoticeable. In my practice, I've found that calming down the immune system and chronic inflammation can take approximately four weeks. If you have a long-standing health condition like an autoimmune disease, full healing usually takes anywhere between three and six months or longer. 

 

Healing gut inflammation requires time and patience. The right protocol eliminates food sensitivities, incorporates plenty of anti-inflammatory foods, and includes gut-supporting nutrients like L-glutamineprobiotics, and prebiotics

 

it has been found that 1-methyl nicotinamide, a metabolite of nicotinamide(FLUSH KIND ONLY WORKS), possesses significant anti-inflammatory properties. Daily treatment resulted in reduced inflammation symptoms [11]

 

https://www.mindbody...al-inflammation

 

I'm gonna take 1g of Nicotinic acid on a empty stomach daily for 20 days hopefully it will recover my gut...


Edited by farshad, 24 September 2019 - 12:38 AM.


#80 farshad

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Posted 24 September 2019 - 02:26 AM

https://www.everyday...s-inflammation/

https://www.ncbi.nlm...les/PMC3805984/

https://www.webmd.co...-inflammation#1



#81 farshad

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Posted 26 September 2019 - 12:54 AM

Hot water is said to be an easy way to improve health. When a person does not drink enough water, the small intestine absorbs most of the water consumed through food and drinking. ... Drinking hot water helps to break down food faster than drinking cold or warm water.

 

tea comes to mind + with high dose niacin after food

 

and in the morning before: memantine high dose (100mg)


Edited by farshad, 26 September 2019 - 12:55 AM.


#82 farshad

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Posted 26 September 2019 - 03:56 AM

Drinking hot water wakes your body’s temperature control system up. As your body compensates for the warm temperature of the water, it brings your internal temperature down, and activates your metabolism.

Hot water also helps your intestines contract to clear out waste products that are bloating your body, which gets rid of the dreaded “water weight.”

https://www.healthli...ps-you-hydrated



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#83 farshad

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Posted 28 September 2019 - 04:50 AM

Diazepam specifically is very lipophilic (fat soluble), so it has a higher likelyhood of being absorbed into the fat deposits in the body rather than float in the 99% water blood stream.



#84 farshad

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Posted 29 September 2019 - 11:16 PM

Reduced bioavailability of inositol in living organisms could arise from reduced food supply or from metabolism deregulation. Inositol deregulation has been found in a number of conditions mechanistically and epidemiologically associated to high-glucose diets or altered glucose metabolism. Indeed, high glucose levels hinder inositol availability by increasing its degradation and by inhibiting both myo-Ins biosynthesis and absorption. These underappreciated mechanisms may likely account for acquired, metabolic deficiency in inositol bioavailability.



#85 farshad

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Posted 30 September 2019 - 12:42 AM

Scientists have now confirmed what they previously tested in mice: the benefits of a bacterium for cardiometabolic health. In a new study, a food supplement containing Akkermansia muciniphila improved metabolic markers in people with prediabetes and at risk of cardiovascular conditions.



#86 farshad

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Posted 30 September 2019 - 10:37 AM

After vitamin B3(niacin), inositol has the second highest store in the body

 

 

Inositol transport proteins
The cyclic polyol myo-inositol is a key molecule in many different metabolic pathways among all organisms; in addition, it is fundamental for osmotic balance in the mammalian brain. This review sums up inositol transporters from eukaryotic organisms, elucidating their vital role in regulating the intracellular distribution and uptake of inositol. They can be divided into two groups according to their transport mechanisms: (1) sodium ion coupled inositol transporters that belong to the Solute Carrier Families 5 and 6-like Superfamily and, (2) proton coupled inositol symporters that are members of the Major Facilitator Superfamily. Intriguingly members of both families offer promising targets for medical treatment of a variety of diseases.
 

Edited by farshad, 30 September 2019 - 10:47 AM.


#87 farshad

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Posted 01 October 2019 - 08:49 AM

2) Induces Intestinal Secretions

In the gastrointestinal tract, 5-HT initiates responses like nausea, intestinal secretion, and peristalsis and has been implicated in gastroenteric diseases like irritable bowel syndrome [4].

The secretory effects of 5-HT are mediated through different receptors: It induces secretion across human ileal mucosa, whereas a receptor of the 5-HT2A subtype appears to mediate the effect in the human sigmoid colon [5].



#88 farshad

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Posted 07 October 2019 - 03:13 PM

Short-term stress can cause you to lose your appetite and your digestion to slow down. Long-term stress can trigger gastrointestinal (GI) issues, like constipation, diarrhea, indigestion, or an upset stomach.



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#89 farshad

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Posted 19 October 2019 - 07:40 AM

Magnesium is an essential element required as a cofactor for over 700 enzymatic reactions. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Another example comes from enzymes in the liver called cytochrome P450 oxidases, which are important in drug metabolism. Induction or inhibition of these enzymes can cause drug interactions. 



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#90 farshad

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Posted 20 October 2019 - 09:54 PM

Ionic form for quick absorption

 

Mega-Mag Liquid Magnesium is a rich, natural source of concentrated magnesium ions with other minerals and trace elements that act as natural co-factors.

Mega-Mag is part of our Liquimins line of ionically charged liquid supplements from Trace Minerals Research. Liquimin are more bio-available and easier to absorb because they’re in a liquid form. And because the minerals are ionically charged, they help with the absorption of other nutrients, too.

They’re perfect for those who prefer taking liquid supplements rather than tablets. And with Liquimins you get all the health benefits of minerals and trace elements with the ease, convenience, and speed of a liquid supplement.

Look for the Liquimins drop on the label and feel the difference a full spectrum of ionically charged minerals can make.







Also tagged with one or more of these keywords: pharmacology, pharmacogenetic, pharmacokinetics

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