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Molecular Choreography of Acute Exercise

exercise fitness molecular pathways biomarkers plasma blood

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#1 Oakman

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Posted 15 June 2020 - 03:24 PM


https://www.biorxiv....3.905349v1.full

 

Abstract

Exercise testing is routinely used in clinical practice to assess fitness - a strong predictor of survival - as well as causes of exercise limitations. While these studies often focus on cardiopulmonary response and selected molecular pathways, the dynamic system-wide molecular response to exercise has not been fully characterized. We performed a longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cells including transcriptome, immunome, proteome, metabolome and lipidome in 36 well-characterized volunteers before and after a controlled bout of acute exercise (2, 15, 30 min and 1 hour in recovery). Integrative analysis revealed an orchestrated choreography of biological processes across key tissues. Most of these processes were dampened in insulin resistant participants. Finally, we discovered biological pathways involved in exercise capacity and developed prediction models revealing potential resting blood-based biomarkers of fitness.

 


Edited by Oakman, 15 June 2020 - 03:39 PM.






Also tagged with one or more of these keywords: exercise, fitness, molecular pathways, biomarkers, plasma, blood

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