LONGECITY

Effect of phosphodiesterase type 5 inhibitors on major adverse cardiovascular events and overall mortality in a large nationwide cohort of men with erectile dysfunction and cardiovascular risk factors: A retrospective, observational study based on healthcare claims and national death index data
https://academic.oup...842?login=false

 

Phosphodiesterase type 5 inhibitor–exposed men had a 25% lower incidence of overall mortality (HR 0.75; 95% CI 0.65-0.87; P < .001). Men without coronary artery disease (CAD) but with CV risk factors at baseline showed a similar pattern.

One possibility is that older men who are having a lot of sex are already in better condition because they also get more exercise. Or it may just be the Viagra.

I think the concept of the study was that viagra increases lifespan but has nothing to do with sex.

Ever since this was published

https://roguehealtha...-drug/#comments

I have been taking small amounts of  generic Sildenafil  almost daily, not for ED but it lowers my blood pressure which stubbornly remains in the high normal  range without it.

See also  https://pubmed.ncbi....h.gov/19627292/

Not too long ago here in Longecity there was a thread on Cialis which is the original brand name for tadalafil, another PDE inhibitor

I am preparing a female mouse lifespan test at home on sildenafil ( https://www.longecit...e-2#entry921120 ). For now my mice are a few months old so the experiment will start in a year and the results will be known in 2.5 years.

I was able to gather sildenafil but I need to organize the placebo now - any view ?

This to confirm or not what is seen in human data --which might be correlation not causation (though I don't think -- I was longly shown that sildenafil produce some cerebrospinal liquid flow and increase vigilance, so it is likely good for neurodegeneration, in addition to be likely good for the vascular system in general. Anti pde3 were also shown to have anticancer effects but it is unclear with anti pde5.

I may as well do it with males but then with no placebo (as I would see males that take sildenafil...)

Nitric oxide!

Promising therapeutic potential of sildenafil beyond its well-established uses. From its role in pain management, neurodegenerative diseases, and systemic sclerosis-associated complications to its impact on cancer, depression, and various organ-specific diseases, sildenafil emerges as a multifaceted therapeutic agent: 

https://pmc.ncbi.nlm...s/PMC10744870/ Exploring the Multifaceted Potential of Sildenafil in Medicine

https://pubmed.ncbi.....gov/40096550/ Sildenafil and risk of Alzheimer disease: a systematic review and meta-analysis

https://pubmed.ncbi....gov/25444755/  PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer

https://viagrala.com/blog/

But what about these side effects?

1. Non-arteritic anterior ischemic optic neuropathy (NAION):

   • This is a rare but serious condition causing sudden, painless vision loss.

   • The association between PDE5 inhibitors like tadalafil and NAION is controversial and not definitively causal, but it's been reported in post-marketing surveillance.

2. Visual disturbances (more common, less severe):

   • Blurred vision

   • Changes in color perception (e.g., blue-tinged vision)

   • Increased light sensitivity

   • These are more commonly associated with sildenafil, but tadalafil can also cause them, though less frequently due to its different PDE subtype selectivity.

• NAION: Very rare. Estimated incidence among users is <1 in 10,000.

• Mild visual disturbances: Occur in about 1–2% of users, typically dose-related and reversible upon discontinuation.

Patients with predisposing conditions such as:

• Hypertension

• Diabetes

• Hyperlipidemia

• Smoking

• Small optic nerve cup-to-disc ratio ("crowded disc")
  ...may be at higher risk of NAION.

Mice don't need placebos, but you might want to give them the same ingredients that are in the excipient.

I am preparing a female mouse lifespan test at home on sildenafil ( https://www.longecit...e-2#entry921120 ). For now my mice are a few months old so the experiment will start in a year and the results will be known in 2.5 years.

I was able to gather sildenafil but I need to organize the placebo now - any view ?

 

This to confirm or not what is seen in human data --which might be correlation not causation (though I don't think -- I was longly shown that sildenafil produce some cerebrospinal liquid flow and increase vigilance, so it is likely good for neurodegeneration, in addition to be likely good for the vascular system in general. Anti pde3 were also shown to have anticancer effects but it is unclear with anti pde5.

 

I may as well do it with males but then with no placebo (as I would see males that take sildenafil...)

What about supplements that have near effects, like citruline malate, taken daily instead of before workout?