6220 replies to this topic

[normalizing]

wow the low dose some people take and notice things. i took so high and nothing except maybe insomnia and irritation. ill try again i guess i have so much left

[Mind_Paralysis]

Hello fellow nsians,

So I started a run with nsi at 20mg per day x2 daily about three days ago. Last night, when leaving a friends house, I was overcome with the urge to jog back to my house. I remember thinking, “wow my body doesn’t hurt for once and I’m enjoying this”. About an hour later, I started to feel tingling on the soles of my feet.

This has persisted since then :( I was hoping that maybe it was just that I hadn’t exercised in a very long time. Or that it was on pavement. But I’m worried now that this might be the dreaded neuropathy symptom.

Nsi has given me back parts of my life I had forgotten were missing. I don’t know if I can go back to what it was like before...

Has anyone else here experienced tingling sensations at the beginning of treatment? Did they go away? Or do they worsen. Should I decrease my dose? I haven’t taken any today.

I appreciate any help you can lend this battered soul :(

Edit: I’m actually in tears right now. This has been the only thing to help me in so many years

 

Many of us have noticed tingling in our extremities, I myself noticed it in my fingers. However, this is generally only on this mild level, of a slight tingling sensation, and usually goes away after a week or two.

 

I suggest you continue to take the NSI-189 - if it's helping as much as you say, then I think it might be worth the tingling sensation. Just keep an eye on it - if it gets worse, you can try LOWERING your dosage, instead of eliminating it all-together - perhaps 20 + 10 mg instead, yes? or maybe 15 + 10 mg.

 

Keep at it! = ) With such high gains, then it is definitively worth it to CONTINUE with the drug.

[Mind_Paralysis]

wow the low dose some people take and notice things. i took so high and nothing except maybe insomnia and irritation. ill try again i guess i have so much left

 

NSI-189 grows the hippocampus, specifically, unless you have a shrunken hippocampus, then it may not actually help... the drug is target-specific.

 

Do you have fMRI or SPECT-scans or something of the like, indicating that you have that form of depression? (classical, with strong cognitive issues - if you have more atypical symptoms, especially with less cognitive issues, like memory, then the drug won't work - you're better off looking into things like CERC-501 then.)
 

[Onemorestep]

Thanks Mind_paralysis, yes i do think I will continue it. I didn’t take any yesterday and the tingling went mostly away when I woke up this morning. I still have some pain, but Im hoping that is from the running. I wasn’t wearing proper footwear and it was truly more than I had run in a long long time. If ever really. I’ve always been more of a bike guy :p

I think I’ll try to go low and slow with it. It took three days for this to happen and I know with the half life that makes some sense with plasma levels. I did also feel very slight tingling in my fingers as well and low level just around my body. It’s not a feeling I’m unfamiliar with since I withdrew from GABA type drugs a year ago. Stimulation for sure.

I wonder if I should let the pain go away first before resuming... I’ve heard that nsi is sometimes tolerated fine until someone gets an injury and then problems start.

If going another day without it is what it takes to be able to take it long term, I’m okay with that. Because yes, the gains are monumental. I’ve never experienced such an unusually effective drug for creating... well normalcy. It by no means cures me, but it gives me a foothold that I consider paramount to my recovery and living a full life. Especially the empathic qualities of it. I completely lost my ability to empathize unless in extreme situations a few years ago and as a result I feel very alone, even with people since I cannot emotionally relate to them. Combined with anhedonia, I have nothing in common with people. It’s not that I’m cognitively unaware of things we can bond over, I just can’t feel it.

Thank you for so promptly responding to my post; I appreciate it so much

If anyone else has any advice or knowledge, I’m all ears!

Edited by Onemorestep, 20 July 2018 - 02:03 PM.

[Onemorestep]

So I restarted the nsi at a low dose of 5mg twice a day. I am getting strange little stings of pain at times but they aren’t too concerning. I’ve had issues with pain for a while and this might just be the nsi making me more aware of what was already there. I’ll slowly titrate up and see how it goes!

My intestinal muscles and ribs are a little wonky but it’s not terrible.

I have to say— the whole “you’ll feel even better when you stop” thing is dead on for me. The first two days off I had a dip in depression and then the third day was just amazing. I spent the whole day outside gardening and let me tell you I’m an indoor dog most of the time.

My feet have 95 percent gotten better. I think I just bruised them trying to run so hard after being sedentary for three years. They probably would have hurt less if I wasn’t on nsi, because as I said before it definetely augments pain for me and anxiety at times.

The one thing I’m starting to find to be pretty unbearable is the insomnia from nsi. It takes hours to fall asleep, I wake up a lot, and it doesn’t feel like restful sleep. Does anyone have any advice for this? Usually I do have problems with waking during the night, but am pretty good with falling asleep. I don’t really like anticholinergics and melatonin, last time I tried it, made me pretty depressed the following day even at doses of 1 mg and under. The only thing I’ve found that helps me sleep is Delta sleep inducing peptide and even that has had finishing returns after sporadic use over the last 3 months. I’ve yet to try it in conjunction with nsi as I have no idea how they will interact. Does this side effect pass in time?

I’m just so insanely curious to learn the MoA for this compound. The effects and side effects are so interesting in how they feel. The insomnia is very similar to the kind I had when I was coming off anti epileptic medication (not for epilepsy) but with less anxiety and physical restlessness.

[Mind_Paralysis]

So I restarted the nsi at a low dose of 5mg twice a day. I am getting strange little stings of pain at times but they aren’t too concerning. I’ve had issues with pain for a while and this might just be the nsi making me more aware of what was already there. I’ll slowly titrate up and see how it goes!

My intestinal muscles and ribs are a little wonky but it’s not terrible.

I have to say— the whole “you’ll feel even better when you stop” thing is dead on for me. The first two days off I had a dip in depression and then the third day was just amazing. I spent the whole day outside gardening and let me tell you I’m an indoor dog most of the time.

My feet have 95 percent gotten better. I think I just bruised them trying to run so hard after being sedentary for three years. They probably would have hurt less if I wasn’t on nsi, because as I said before it definetely augments pain for me and anxiety at times.

The one thing I’m starting to find to be pretty unbearable is the insomnia from nsi. It takes hours to fall asleep, I wake up a lot, and it doesn’t feel like restful sleep. Does anyone have any advice for this? Usually I do have problems with waking during the night, but am pretty good with falling asleep. I don’t really like anticholinergics and melatonin, last time I tried it, made me pretty depressed the following day even at doses of 1 mg and under. The only thing I’ve found that helps me sleep is Delta sleep inducing peptide and even that has had finishing returns after sporadic use over the last 3 months. I’ve yet to try it in conjunction with nsi as I have no idea how they will interact. Does this side effect pass in time?

I’m just so insanely curious to learn the MoA for this compound. The effects and side effects are so interesting in how they feel. The insomnia is very similar to the kind I had when I was coming off anti epileptic medication (not for epilepsy) but with less anxiety and physical restlessness.

 

Gabapentin may help.

 

At least, it did so for me. Others have reported this as well (on reddit, as I recall). However, there's a caveat - the reason it helps, is because it temporarily ABOLISHES the effects of NSI-189 - gabapentin has been shown to partially work via inhibition of neurogenesis in the hippocampus - the exact opposite of NSI. This may be the reason why some experience depressive symptoms while on gabapentin.

 

I'd suggest to give it a try, as long as you take it the right time of the evening, so it has time to properly wear off until you wake up, and keep the dosage low - 150 - 300 mg is the dosage which has been studied and found to enhance stage 4, deep sleep. 600 mg was also tested, but was not found to have any greater benefit than 300 mg - with that said, I'm guessing even if 300 mg doesn't help, it might still be worth to test 450 mg. (at higher dosages of other drugs which disrupts stage 4 sleep, this is what i did, and it worked. I have something called PLMD though - a disease which causes a disruption in stage 4 sleep and makes your arms and legs twitch wildly while you sleep)
 

[Onemorestep]

Unfortunately I don’t think gabapentin is an option :( I just spent the last year tapering off it and lorazepam (down to 15mg gabapentin and .25mg lorazepam). I was only on them for 8 months before I started my taper and it’s made my life more difficult than it was worth tbh. It’s messed up my hair and nervous system for a long time.

Also, I react VERY strongly to GABA drugs. I get a rebound that is similar to ghb with Some of them (mostly just the GABA B drugs— baclofen, gabapentin). This is marked by sedation at first, followed by slightly better sleep, and then the next day or two markedly decreased anhedonia, energy, and social behavior. After that there is a crash where these symptoms worsen for a week or two.

I haven’t been able to figure out completely what is causing this, but my anhedonia does tie into GABA and glutamate. Dysfunction. There are a lot of similarities to the negative symptoms of schizophrenia.

I was on baclofen (up to 100mg) for 8 months to deal with spasticity issues. It worked better than anything I’ve tried for anhedonia and motivation. Plus, it solves a lot of cognitive dysfunction I had been experiencing. One day I woke up and couldn’t feel any pleasure anymore. My theories for this are mostly related to the NaC and GABA/glutamate signaling, glutamate burnout, and imbalances between acetylcholine and other major neurotransmitors. There is some evidence that baclofen might cause the brain to lean towards cholinergic dominance: https://www.ncbi.nlm...pubmed/7329897/

So I wonder if the baclofen was causing increases in cholinergic dominance, increasing my memory etc, while also having effects similar to ghb through glutamate rebound and dopamine release. Eventually tolerance rose to the glutamate and dopamine effects (or neurotoxicity over time) and I was left with a lot of acetylcholine and not enough dopamine to level things out.

My experimentation with certain medications has made me think I was in at least the right general direction with this. Sinemet severely decreased depressive symptoms for about a week before tapering off.

Very minor withdrawals (reduction of dose by 10mg a day) of levetiracetam, which would theoretically increase levels of glutamate and dopamine, had the effect of markedly decreasing my anhedonia and depersonalization.

There is also some research out there between the interplay of nmda receptor hyperfunction and decreasing levels of acetylcholine functioning in the brain, although I can’t remember right now where I was reading this. I think this helps explain some of the cognitive dysfunction that people experience after going through benzo withdrawal that last for a very long time if not forever.

All just theories though hard to ever figure it out for sure. I’ve become more interested in finding something that works than figuring out the maze that has been my neurology over the past ten years.

Don’t even get me started about my gene mutations. That stuff is A MESS. When I got my results, I though “wow no wonder I’m a wreck”. I have so many double whammies out there related to problems making GABA, decreasing glutamate, and processing dopamine/norepinephrine.

[Mind_Paralysis]

Unfortunately I don’t think gabapentin is an option :( I just spent the last year tapering off it and lorazepam (down to 15mg gabapentin and .25mg lorazepam). I was only on them for 8 months before I started my taper and it’s made my life more difficult than it was worth tbh. It’s messed up my hair and nervous system for a long time.

Also, I react VERY strongly to GABA drugs. I get a rebound that is similar to ghb with Some of them (mostly just the GABA B drugs— baclofen, gabapentin). This is marked by sedation at first, followed by slightly better sleep, and then the next day or two markedly decreased anhedonia, energy, and social behavior. After that there is a crash where these symptoms worsen for a week or two.

I haven’t been able to figure out completely what is causing this, but my anhedonia does tie into GABA and glutamate. Dysfunction. There are a lot of similarities to the negative symptoms of schizophrenia.

I was on baclofen (up to 100mg) for 8 months to deal with spasticity issues. It worked better than anything I’ve tried for anhedonia and motivation. Plus, it solves a lot of cognitive dysfunction I had been experiencing. One day I woke up and couldn’t feel any pleasure anymore. My theories for this are mostly related to the NaC and GABA/glutamate signaling, glutamate burnout, and imbalances between acetylcholine and other major neurotransmitors. There is some evidence that baclofen might cause the brain to lean towards cholinergic dominance: https://www.ncbi.nlm...pubmed/7329897/

So I wonder if the baclofen was causing increases in cholinergic dominance, increasing my memory etc, while also having effects similar to ghb through glutamate rebound and dopamine release. Eventually tolerance rose to the glutamate and dopamine effects (or neurotoxicity over time) and I was left with a lot of acetylcholine and not enough dopamine to level things out.

My experimentation with certain medications has made me think I was in at least the right general direction with this. Sinemet severely decreased depressive symptoms for about a week before tapering off.

Very minor withdrawals (reduction of dose by 10mg a day) of levetiracetam, which would theoretically increase levels of glutamate and dopamine, had the effect of markedly decreasing my anhedonia and depersonalization.

There is also some research out there between the interplay of nmda receptor hyperfunction and decreasing levels of acetylcholine functioning in the brain, although I can’t remember right now where I was reading this. I think this helps explain some of the cognitive dysfunction that people experience after going through benzo withdrawal that last for a very long time if not forever.

All just theories though hard to ever figure it out for sure. I’ve become more interested in finding something that works than figuring out the maze that has been my neurology over the past ten years.

Don’t even get me started about my gene mutations. That stuff is A MESS. When I got my results, I though “wow no wonder I’m a wreck”. I have so many double whammies out there related to problems making GABA, decreasing glutamate, and processing dopamine/norepinephrine.

 

Hmm.

 

Well, then I would suggest you look into Mirtazapine and Trazodone - they are 5ht2a-antagonists, which have also been found to increase slow-wave stage 4 sleep. They're also both obviously very sedating as well.
 

[WonderKid]

Hello everyone, I have excessive sugar use and some depression in my past and my memory can definitely use some help, so I'm considering trying NSI-189.

 

Can you please advise where and how to get it ?

 

I don't want a fake product but I don't want to pay extra for things like brand value, encapsulation, less shipping time. It doesn't sell in my country and customs may potentially be a problem anyway so I guess it would be best to find a reliable supplier from alibaba. At worst I'll have it shipped to a friend without customs problems and he'll bring it to me.

 

Also, is there sth you would suggest me to stack NSI-189 with ? I already have some pregnenolone, pyridoxal-5-phosphate, sulbutiamine, grape seed extract, glycine, creatine that I can use without noticing side efects.

 

My health problems are dust mite allergy(mainly asthma but also allergic conjunctivitis and allergic rhinitis). I could use some help about those or reducing "specifically" visceral (belly) fat / increasing anabolism / reducing catabolism too if there is sth really worth trying about these without worrisome side / withdrawal effects.

[Breakthrough]

Gabapentin may help.

At least, it did so for me. Others have reported this as well (on reddit, as I recall). However, there's a caveat - the reason it helps, is because it temporarily ABOLISHES the effects of NSI-189 - gabapentin has been shown to partially work via inhibition of neurogenesis in the hippocampus - the exact opposite of NSI. This may be the reason why some experience depressive symptoms while on gabapentin.

I'd suggest to give it a try, as long as you take it the right time of the evening, so it has time to properly wear off until you wake up, and keep the dosage low - 150 - 300 mg is the dosage which has been studied and found to enhance stage 4, deep sleep. 600 mg was also tested, but was not found to have any greater benefit than 300 mg - with that said, I'm guessing even if 300 mg doesn't help, it might still be worth to test 450 mg. (at higher dosages of other drugs which disrupts stage 4 sleep, this is what i did, and it worked. I have something called PLMD though - a disease which causes a disruption in stage 4 sleep and makes your arms and legs twitch wildly while you sleep)

[Mind_Paralysis]

 

Gabapentin may help.

At least, it did so for me. Others have reported this as well (on reddit, as I recall). However, there's a caveat - the reason it helps, is because it temporarily ABOLISHES the effects of NSI-189 - gabapentin has been shown to partially work via inhibition of neurogenesis in the hippocampus - the exact opposite of NSI. This may be the reason why some experience depressive symptoms while on gabapentin.

I'd suggest to give it a try, as long as you take it the right time of the evening, so it has time to properly wear off until you wake up, and keep the dosage low - 150 - 300 mg is the dosage which has been studied and found to enhance stage 4, deep sleep. 600 mg was also tested, but was not found to have any greater benefit than 300 mg - with that said, I'm guessing even if 300 mg doesn't help, it might still be worth to test 450 mg. (at higher dosages of other drugs which disrupts stage 4 sleep, this is what i did, and it worked. I have something called PLMD though - a disease which causes a disruption in stage 4 sleep and makes your arms and legs twitch wildly while you sleep)

?

 

Yes? Is there a question here? Did you make a slight miss-post by chance?
 

[Breakthrough]

Hey Mind_paralysis, it was a mis-post.  But I am curious how your SCT symptoms are coming along with the NSI, and if the strattera has continued to help.

[2Aleph Naught]

I'm a little more than a month into my NSI-189 journey now and so I thought I'd give another little update. I know that when I was researching this chemical I wanted somebody to have kept an updated effects log / journal for me to see possible progression. So hopefully my reports are helping somebody out there.

 

I decided to push for a faster recovery with Anhedonia / DP / Depression by upping my dose in week 3 from 40mg QD to 40mg BiD but that turned out to be a mistake. This chemical has a very long half life (~20 hours) so it took about 4 days for enough of this new dose to accumulate to notice my mistake. When I first went from 40mg to 80mg in a day I felt about the same for a few days, maybe a little less awake in the morning, on day 4 this effect was very pronounced. I woke up in a sort of fog on day 4 and not even coffee snapped me out of it. I was slower in my cognition and had a harder time responding to people socially. Like there was a wall between myself and my thoughts, I just didn't have access to my usual depth of processing which made me feel disconnected. It felt like brain fog mixed with depression and I must have seemed anti-social because I remained isolated and very quiet.

Also at this time my mental imagery went to shit and my dreams because less frequent and when present less memorable.

 

I backed it down again to 40mg QD (in the morning when I get up) and after a few days things started to brighten up again. About 5 days I'd guess.

 

Things I've noticed improving are my experiential memories, vision, mental imagery, mood and weirdly my hand-eye coordination.

 

Prior to NSI I didn't have much in the way of a third eye, like I couldn't conjure pictures of faces in my mind or of locations I've been. You can imagine how that hinders building a memory palace . After this month with NSI I'm starting to get little blips of scenes and with some effort I can "see" celebrity faces. My working memory (maybe short term?) has also improved in this way. 5 days a week I park in a parking garage and have to remember a number marking my spot to pay for parking. I used to repeat the number to myself on my way to pay but now I look at the spot and actually keep an image of the spot's # (little placard thing) in my mind. It's an awesome feeling.

 

I'm really hoping this chemical continues to strengthen my mental imagery as I'd love an eidetic memory. It seems to be getting a little bit better each day with practice .

 

Prior to NSI I wasn't a very social person, not that there's anything wrong with being quiet of course. I could talk with people and get along alright, but I didn't exude much warmth or at least I wasn't feeling it. After this month with NSI I'm coming around a little bit, after the 80mg fiasco anyhow.. It's a weird thing to describe and maybe even impossible for somebody not accustomed with DP to understand. I feel more 'right' in a social setting, like I can understand other people better maybe and have a more genuine response to them. My conversations prior to NSI felt very formulaic, sort of like following a flowchart with how I responded. I'm thinking more laterally now, I feel like I'm engaging in conversations for the fun of it (that's why people do it right?) and I get good feelings sometimes. They're very subtle and fleeting feelings of connectedness.

 

Having been diagnosed with all the different disorders starting with schizo these effects are very strange to me. I like it I think and maybe this becomes natural for me eventually but right now I wish NSI would hurry up and give me the full 'being human' feeling already. My family is seeing the change and they seem really impressed with me, so I guess that's good.

 

I don't know if I mentioned it in my previous logs but after the first week of NSI my vision became sharper. My color saturation seems to have gone up and object contrast is also up. I notice it best on a sunny day outside looking at nature. There doesn't seem to be a difference sitting here just looking around my room. The vision boost also came with hand-eye coordination increases. I'm a skill toy demonstrator (juggling, yoyo, kendama, devil stick, etc...) and I find myself able to visualize the tricks while I perform them better, I feel more accurate when judging distances and seeing objects spin speed. This could be placebo too or just an affect of practicing a lot .

 

If people are curious about my experience or just me as a person I'm open to answering any questions you have .

 

I'm going to try and keep this log going to help people interested in trying NSI-189 see all what can happen in time.

 

-

∞

[Teddy]

Still tempted by the NSI in my cupboard but I get a sharp dysphoric anxiety (which I do not ususally have anxiety issues at all) on as little as 7-8mg every time I try it. (I have the free-base). I've tried to stay on it for up to a week but never noticed any relief from depression or anhedonia and increasing the dosage seems like it will be impossible, so maybe it just isn't for me. I absolutely am a "delicate flower" when it comes to any substances, and cannot even tolerate coffee or b-vitamins etc., so don't let my sensitivity dissuade anyone. 

 

Anyway, came across this PR by Neuralstem and didn't see that it had been posted. Looks like they are gonna go after the Alz market. 

 

 https://www.streetin...e/14422635.html

[WonderKid]

I guess the most important thing to stack with NSI-189 must be a good sleep aid given its 17.4 to 20.5 hours mean half life:

 

https://www.prnewswi...-300189383.html

Edited by WonderKid, 25 July 2018 - 08:09 PM.

[2Aleph Naught]

Have any of you tried stacking dihexa with NSI? I read somewhere that they have good synergy; can anyone here confirm?

[bialas55]

Still tempted by the NSI in my cupboard but I get a sharp dysphoric anxiety (which I do not ususally have anxiety issues at all) on as little as 7-8mg every time I try it. (I have the free-base). I've tried to stay on it for up to a week but never noticed any relief from depression or anhedonia and increasing the dosage seems like it will be impossible, so maybe it just isn't for me. I absolutely am a "delicate flower" when it comes to any substances, and cannot even tolerate coffee or b-vitamins etc., so don't let my sensitivity dissuade anyone.

Anyway, came across this PR by Neuralstem and didn't see that it had been posted. Looks like they are gonna go after the Alz market.

https://www.streetin...e/14422635.html

in the freebase version and sublingual administration, almost everyone complained about anxiety, try phosphate should be better

if somebody takes phosphate orally for a while and does not feel any effects, then maybe he should try sublingual delivery. I took 40 mg twice a day, without a revelation for three months. Since Friday I have started again and today I have taken sublingually and this taking is really perceptible than in the case of oral administration. I remember that in the freebase version there was anxiety after sublingual; at phosphate, it is negligible, almost imperceptible (at least in my case). so much from me

[magniloquentc0unt]

i remember someone mentioning taking nsi with moclobemide, does that help the sadness and negative outlook?

somehow i dont seem to be able to take nsi without triggering some sort of depression and pessimism..

[jag604]

Hopefully someone can answer quick,

Do I take it with food or without. Finally starting this morning. I capped 20mg.

Edited by jag604, 02 August 2018 - 03:40 PM.

[LmaoZedong]

Hello! I'm new so I haven't been able to read many post in this thread. I do, however, remember seeing some posts that suggest taking tianeptine with NSI-189.

 

Earlier today, I chanced upon this article and in particular, this sentence: "Tianeptine reduces the hypothalamic-pituitary-adrenal response to stress, antagonises stress-induced behavioural deficits and prevents changes in cerebral morphology. " - https://www.ncbi.nlm.../pubmed/7774514

 

Has anyone brought this up before? I can only find the general statement that NSI-189 was found to increase neurogenesis in rats, but nothing detailing how. I also do not have access to the full article, only the abstract, so I'm not sure how tianeptine is supposed to suppress "changes to cerebral morphology".

 

Edited by LmaoZedong, 02 August 2018 - 08:23 PM.

[Robinvanpersie]

According to the studies that have been made, how is the best way of taking it?

 

20-40-60-80-120mg per day? Start low and then increase?

Doses split into two, three or take it all immediately? (I think I've read that it should be spread out to keep steady levels of NSI-189 in the blood)

How many hours between the doses?

[snotz14]

40 mg Q.D is the best dose to take according to the secondary endpoints of the phase 2 study.

[Onemorestep]

I think I’m starting to get the infamous anxiety from the nsi at 20mg x2 daily. Last few days I’ve been waking up pretty anxious and yesterday when I took my afternoon dosage I had a panic attack for several hours. Nicotine seems to make it worse where I didn’t have a problem with that before. I’ve been on nsi for about two weeks.

Honestly I’m not sure whether to continue or not. The effects I noticed in the first days of the trial are not really noticeable anymore.... except for colors are still brighter than they used to be and clouds look a lot more 3D instead of flat.

I wish I could use tianeptine. It makes me kinda crazy after a few days though.

[Robinvanpersie]

40 mg Q.D is the best dose to take according to the secondary endpoints of the phase 2 study.

Thank you. What does Q.D mean?

Should I take 40mg at once or in two doses?

[2Aleph Naught]

Thank you. What does Q.D mean?

Should I take 40mg at once or in two doses?

 

Q.D is once a day dosing. So 40mg QD means you take 40mg total in a day.

QD is latin for quaque die (Which in Latin means once a day)

 

You'll also come across BiD and TiD on these forums. They mean twice a day (BiD) and three times a day (TiD) respectively.

Edited by 2Aleph Naught, 03 August 2018 - 07:45 PM.

[snotz14]

40 mg per day, and I think it doesn't matter if you split the dose: " Steady state was reached after 96–120 h, consistent with the T½ and independent of the dosing regimen"¹

Perhaps, it is benefical to take the dose on empty stomach, but I'm not sure about it. Possibly, you could find the answer in the source attached. 

1)https://www.nature.c...icles/mp2015178

[MedMad]

Hello Longecity.. please forgive the long post
(I’ve already posted this message on the introduction page as it seems I can post here now)

My real name is Jason, 48, English origin, live in France..
Im in a lot of trouble & really need help & advice.
I’ve been on psy medications since 1998. 1st it was a simple panic attack from smoking to much cannabis.. no sign of any mental illness before that, no depression.. medication prescriptions started with benzos.. became very addicted.. then ADs were added, from that moment depression symptoms started & from that time till now I’ve tried multiple times to get off meds unsuccessfuly & my life has been ruined because of it.. I also suffer hypersensitivity to everything now & suffer incredibly long withdrawals (benzos took me 4 years to get better from after stopping.. infact not sure if I ever got over that).

Since November last year was in hospital.. was on treatments more or less stable for 5 years.. came in to do a cannabis withdrawal.. they stopped my meds over night, tried to put in new ones & from that moment I flipped.. they put me on ADs it made me aggressive, Neuroleptics made me dead & incapable of functioning at all + everything had massive intolerable side effects.. after multiple changes it was clear I could not tolerate meds at all,. they then cold turkied me 2 months ago.. I’ve been very sick ever since.. suffering massive anxiety & depression, physical pains beyond belief, a strange sensation that the front of my brain has gone totally numb, as if it’s stopped functioning, with agonizing back/spinal pains.. cramps in fore arms/hands & fingers..

I’ve tried every supplement that I could get my hands on to help my symptoms.. very little if any relief, I think some actually worsened things.. last attempt was Mind Lab Pro but seemed to make me worse in someways & just would not stabilize my symptoms.. I’m trying NAC, high dose epa/dha omega 3 Fish oil pills & Lithuim orotate 10mg a day but so far practicaly no relief.. have just ordered some CoQ10 but I’m a little afraid stimulating dopamine might actually have the same effect as some of the ingredients that Mind Lab Pro had.. maybe I should try it longer ?

So, I’m now wondering if I should try NSI-189 as nothing else is really helping to ‘heal’ my brain & help my symptoms.. I’m still unaware if my symptoms are all withdrawal related or if I’ve developed a very long term or perminant brain disfunction.. I’d like to ask advice where to find the best/cheapest sources for me to approch.. it seems the phosphate version has less side effects & works better.. I’m on disability benifit so cost is really important.. basically I have to find a minimum of substances to help stabalize me & if it’s all related to withdrawals that might last months products that help ‘fix’ any brain damage..

Please don’t ask me to go back to hospital or see another shrink as they have all refused to help me.. they kicked me out of hospital because I could not tolerate medications & no drs here know anything about supplements or how to treat my symptoms.. in France it’s all about hard drugs & that’s it.. I’m scheduled to try rTMS in October though I’m not sure it will help much, may even make things worse, but I still have to find a product or products that can help.. I’ve contacted multiple ‘alternative’ hospitals around the world, multiple forums, many individuals, approched companies like truehope & Hardy Nutritionnels.. even bought their products.. even tried an rTDCS machine, each person/company have different advice.. would be a god send to find someone who can tell guide me what to take & not take..

Thank you in advance to anyone who can advise me..

[MedMad]

.. I hope some people can help .. I’m really counting on NSI-189 being able to lift depressive symptoms a bit .. maybe even anxiety .. please feel free to PM me if you don’t want to post certain advice or info here .. thx

[kyle75]

I came across this study that says that ketamine is able to translocate the subunit Gsalpha from lipid rafts in 15 minutes, dose-dependent, what SSRIS and MAOIs can only achieve in about 3 weeks. For those who wonder what I'm talking about, the latest theory on how antidepressants work happens to be the translocation of Gsalpha out of lipid rafts on the surface of the cells where the signaling is inefficient, to non-cholesterol areas, where the induction of cAMP is much more efficient. 

 

Recent studies have shown that molecules who are antidepressants can translocate the Gsalpha out of lipid rafts (or cholesterol-containing rafts) whereas other molecules such as antipsychotic don't have any impact in this regard. So, since it's now the latest theory, I woudl be mighty interested to know if NSI-189 has any incidence to that effect. 

 

 

Also docosahexaenoic acid (a component of fish oil) also exhibit the same translocating behavior. 

 

Here is the study on ketamine: https://www.fasebj.o...upplement.929.5

 

Unfortunately I can't find the study that shows that only known antidepressants have the property to translocate the Gsalpha: that study specifically shows that  escitalopram has this property to translocate the Gsalpha whereas citalopram does not. Edit: I found the study that shows that R-citalopram has not effect on the location of the subunit Gsalpha, whereas escitalopram does translocate the subunit: https://www.ncbi.nlm...les/PMC2835448/

 

I think this would be worth a thread in itself but I'm too lazy/withdrawn right now. 

Edited by kyle75, 05 August 2018 - 10:57 AM.

[MedMad]

Thank you.. exelent post.. at the moment trying to take Lithium orotate 10/15mg a day with omega 3 high dose & NAC when needed .. it’s not working to well .. I wonder if NAC & LiO have this magic effect you mentioned .. also, for anyone interested in buying NSI-189 phosphate powder at very low cost, I did a packet of research & found a reputable supplier through a person on Reddit who has bought from this source.. it’s a company called Xi’an Lyphar Biotech Ltd .. can be found on Alibaba.com.. ask for Cathy.. price quoted, $75 for 10g or $40 for 5g + $15 for delivery.. hope it’s ok to put this info as it might help people.. if not just delete it from my post.. however I’m not sure how I’m going to mesure 20 or 40mg quantities without some very accurate scales & Ill have to buy some empty pills..