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NSI-189

nsi-189

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#6061 jag604

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Posted 08 October 2018 - 08:42 PM

I did - I had, and have, reduction of cognitive abilities from Occupational Burnout (neuro-imaging have connected these issues to damage to the hippocampus, the specific region NSI affects) - I did testing prior to taking NSI-189, and also about 2-3 weeks after starting it.

As I recall... The tests showed improvements in SOME domains, but also new reductions in others - rather curious.

I never did what I should have done, and did some testing a few weeks after coming off of it... so I don't know if I got any overall cognitive improvements from the trial. (my adhd + sct prevents any such consistent behaviour)
 

 

What kind of testing? Where? How/



#6062 Mind_Paralysis

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Posted 09 October 2018 - 03:52 PM

I did the testing using Cambridge Brain Sciences various testing-tasks. If I get out of my current slump, I may be able to dig up the data I do have.

 

The protocols the website uses, have been devised by neuroscientists working at Cambridge University - apparently the data collected is also used for research, if I'm not mistaken?



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#6063 Minkowski

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Posted 09 October 2018 - 04:45 PM

Okay thanks, nobody else have been throught objective neuropsychological assesment of the benefits he felt over the course of his nsi 189 cure...?

#6064 jag604

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Posted 09 October 2018 - 06:24 PM

If I get out of my current slump

 

Sorry to hear you're in a slump.  Have you tried any other nootropics to help you?  An afanil or racetam?  Or even an SSRI?  



#6065 Mind_Paralysis

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Posted 10 October 2018 - 08:13 PM

Sorry to hear you're in a slump.  Have you tried any other nootropics to help you?  An afanil or racetam?  Or even an SSRI?  

 

Only tianeptine Sulphate, since that's all I've got lying around. I'm going to try to get ahold of some NSI-189 soon though. I've actually got an appointment with my Dr. this week, so I foresee myself starting Fluoxetine very soon.



#6066 yinyang

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Posted 17 October 2018 - 06:46 PM

Something very interesting, related to NSI-189

In addition, concurrent administration of P7C3 compounds and pro-proliferative compounds like NSI-189 might have a synergistic effect in enhancing hippocampal neurogenesis and treating depression or hippocampal-related cognitive dysfunction in patients suffering from a spectrum of neurodegenerative conditions related to injury, disease, or normal aging.

https://www.ncbi.nlm...pubmed/30258178

#6067 wanderlust

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Posted 05 November 2018 - 03:13 AM

i have a question for members like myself that have trailed Nsi-189 some time ago .

 

 

 

What was your income level and financial landscape like before trialling Nsi-189?  &What did your finances look like 1 year after trailing  nsi-189

 

if you would also provide details of how long trailed nsi-189. that would be great .

 

for my self 

 

it is now over 2 years since i trailed nsi-189  for 12 months  

When i began the trial i described my self as a happy person and was interested in increasing the size my brain.

 

 i considered nsi to be a nice " pick me"  and a nice change from modafinal up until at the 4 month mark where  naturally started to feel a level and depth of natural happiness i had never previously felt I continued the study until the end of the 5th month 

 

here are cold finacal fcts for me 

2 years Before nsi-189  my income was 

 

 

 



#6068 jag604

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Posted 06 November 2018 - 03:42 AM

i have a question for members like myself that have trailed Nsi-189 some time ago .

 

 

 

What was your income level and financial landscape like before trialling Nsi-189?  &What did your finances look like 1 year after trailing  nsi-189

 

if you would also provide details of how long trailed nsi-189. that would be great .

 

for my self 

 

it is now over 2 years since i trailed nsi-189  for 12 months  

When i began the trial i described my self as a happy person and was interested in increasing the size my brain.

 

 i considered nsi to be a nice " pick me"  and a nice change from modafinal up until at the 4 month mark where  naturally started to feel a level and depth of natural happiness i had never previously felt I continued the study until the end of the 5th month 

 

here are cold finacal fcts for me 

2 years Before nsi-189  my income was 

 

Did you forget to finish?  It sounded like you were going to tell us your income before and after and how it impacted you but it cut off.  How did the 12 month run go?  Was it worth it? Was there a significant decline, lasting impact?  Recommend it? Don't recommend?



#6069 stefdude

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Posted 09 November 2018 - 01:06 PM

NSI-189 gives me slight mood boost and quite an energy boost, especially in the morning.I wake up and get going noticeably easier.I get the benefits in less than 1 week from starting it and I've taken it for 1 month at most.I'll try longer cycles now.

40mg x 2 gave me side effects after a while:

cognitive sides:I was forgeting important tasks I had to do, general short term memory problems, difficulty finding some less common words when speaking (reduction of vocabulary in general)

head pressure, mainly the top of my head

 

40mg once was effective with no sides

 

Tried combining with Tianeptine sulfate for about a week+, no extras.I've tried Tianeptine solo too and I always get nothing.I've tried even 50mg sublingually or intranasally with no effects whatsoever

 

Along with NSI-189 I'm taking KSM-66 500-600mg 5 times per week, Mucuna Pruriens 1.5-2gr 5 times per week



#6070 adamh

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Posted 10 November 2018 - 02:42 AM

Does anyone know of a source for nsi 189? I tried contacting strangelove and he said he would sell me some when it came in in a week or so. This was about 6 weeks ago and he has not given an update and has not replied in several weeks even though I inquired. I hate to bother him further.



#6071 stefdude

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Posted 10 November 2018 - 01:51 PM

He hasnt received it yet from what I know.He had some unexpected things and is quite busy lately.He should get it soon.
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#6072 yinyang

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Posted 12 November 2018 - 06:15 AM

Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by a small neurogenic molecule, NSI-189.

 

There's also a proposed mechanism of NSI-189


Edited by yinyang, 12 November 2018 - 06:32 AM.

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#6073 Mind_Paralysis

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Posted 12 November 2018 - 09:22 PM

 

Now THAT was some interesting stuff! If I get that correct... then it would appear as if NSI-189 is an agonist at multiple sites where otherwise BDNF would be the bodies own natural agonist? That makes a lot of sense, if this really turns out to be the case.

 

But can someone please crosscheck this with Neuralstem's officially released list of different receptors/kinases etc which they tested NSI-189 for? It would be interesting to see if these two pathways are in there or not...

 

 

On another, slightly concerning note...! : ( Much like Dihexa, one of these pathways... is involved in the growth of a specific cancer! It may only be an issue if you're a woman? If I read the info on the pathway correctly, but still... that's concerning.


Edited by Mind_Paralysis, 12 November 2018 - 09:23 PM.

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#6074 adamh

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Posted 14 November 2018 - 02:59 AM

He hasnt received it yet from what I know.He had some unexpected things and is quite busy lately.He should get it soon.

 

Thanks for the info. That means it may arrive eventually. He may be tired of people asking about it.


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#6075 Strangelove

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Posted 17 November 2018 - 09:02 PM

It has been more than a while since I read my private messages or posts in the thread. Sorry for those that wait for NSI-189, I will send it and give them a full refund asap! I had some odd issue (to say the least) together with an accident, that had me in the hospital for a few days. Probably as many here I have tried far more chemicals that the average person can think of, but I had something unexpected happening to me trying the mood stabilizer topiramate. 
 
The easiest way to describe it is some weeks of mild psychosis, hearing no voices (thank you very much, and some very minor illusions) in the "beautiful mind" movie spy theme... I never had any prior issue and I am very down to earth, but after getting some accurate psychological analysis (commercial) for a project, I started thinking (a week maybe after taking topiramate) that "some people" got aware that I can "possibly help them" and are after me with force, or "bribes" to do so. It sounds/seems to me ridiculous now... But at the time I was using topiramate seemed very real! I was semi-functional as they were days the paranoia(at the extreme, ideas that I was about to get been killed) was at the extreme, following days about my importance as a "strategic thinker" :P and some technical knowledge I have, but the story was unreal and made me realize I have to be even more careful of what I will be trying in the future...
 
From statistics, acute psychosis happens in about 1/130 people trying this mood stabilizer without having a prior history of the illness. Myself I do not even need a mood stabilizer but it has some anxiolytic properties that have helped a friend, and thought I have tried a ton of chemicals with no serious issues, what a short trial with low doses mood stabilizer could possibly do?
Looking the side effects of any drug there are some serious one mentioned, and you might be the one having the rare strong one/s, and even experienced users must do a lot of research (somehow I did not pay attention of the psychosis side effect and search about it later) to confirm my idea that the "weird ideas" were from topiramate. Thankfully all the odd thinking pattern disappeared only after two days after the last dose. 
 
As I said it has been a while, but I will get back to PMs tomorrow! I also took a necessary... break from work. Thankfully no one realized anything... When I was in front of people I knew for a long time my behavior was (thankfully) normal. 


#6076 jag604

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Posted 17 November 2018 - 10:42 PM

 

It has been more than a while since I read my private messages or posts in the thread. Sorry for those that wait for NSI-189, I will send it and give them a full refund asap! I had some odd issue (to say the least) together with an accident, that had me in the hospital for a few days. Probably as many here I have tried far more chemicals that the average person can think of, but I had something unexpected happening to me trying the mood stabilizer topiramate. 
...
As I said it has been a while, but I will get back to PMs tomorrow! I also took a necessary... break from work. Thankfully no one realized anything... When I was in front of people I knew for a long time my behavior was (thankfully) normal. 

 

 

Hey Strangelove,

 

I'm glad you're okay.  Take your time and continue to heal up!  While we need our "fix", you come first so please be healthy.



#6077 jag604

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Posted Yesterday, 09:05 PM

So... I've been very sporadic with taking NSI-189 and I haven't read through the 203 pages of text..maybe one day.  

 

I do notice that the days I take it, I am much more energetic.  I don't have depressive thoughts, my anxiety is a little high depending on what's going on but overall I would say my quality of life is greatly increased when I take it.  I'm not sure it's a placebo effect but I can tell you that I want it to continue.  

 

I think I will start taking it on a much more regular basis as long as I can get my hands on more of it!

 

Thank you to this forum and thanks to Strangelove for providing it.



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#6078 celticlion76

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Posted Yesterday, 11:48 PM

Sorry to hear that mate, I can totally relate, after years of feeling impervious to these (always apparently) innocent powders I think I have caused some problems with my kidneys and need to get checked out asap, and  Hope you recover well soon.

 

It has been more than a while since I read my private messages or posts in the thread. Sorry for those that wait for NSI-189, I will send it and give them a full refund asap! I had some odd issue (to say the least) together with an accident, that had me in the hospital for a few days. Probably as many here I have tried far more chemicals that the average person can think of, but I had something unexpected happening to me trying the mood stabilizer topiramate. 
 
The easiest way to describe it is some weeks of mild psychosis, hearing no voices (thank you very much, and some very minor illusions) in the "beautiful mind" movie spy theme... I never had any prior issue and I am very down to earth, but after getting some accurate psychological analysis (commercial) for a project, I started thinking (a week maybe after taking topiramate) that "some people" got aware that I can "possibly help them" and are after me with force, or "bribes" to do so. It sounds/seems to me ridiculous now... But at the time I was using topiramate seemed very real! I was semi-functional as they were days the paranoia(at the extreme, ideas that I was about to get been killed) was at the extreme, following days about my importance as a "strategic thinker" :P and some technical knowledge I have, but the story was unreal and made me realize I have to be even more careful of what I will be trying in the future...
 
From statistics, acute psychosis happens in about 1/130 people trying this mood stabilizer without having a prior history of the illness. Myself I do not even need a mood stabilizer but it has some anxiolytic properties that have helped a friend, and thought I have tried a ton of chemicals with no serious issues, what a short trial with low doses mood stabilizer could possibly do?
Looking the side effects of any drug there are some serious one mentioned, and you might be the one having the rare strong one/s, and even experienced users must do a lot of research (somehow I did not pay attention of the psychosis side effect and search about it later) to confirm my idea that the "weird ideas" were from topiramate. Thankfully all the odd thinking pattern disappeared only after two days after the last dose. 
 
As I said it has been a while, but I will get back to PMs tomorrow! I also took a necessary... break from work. Thankfully no one realized anything... When I was in front of people I knew for a long time my behavior was (thankfully) normal. 

 

 







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