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GTS-21/DMXB-A

gts-21 dmxb-a dmxba

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#61 scibor1

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Posted 27 January 2014 - 06:15 PM

In.

Would you be willing to divulge your supplier should someone offer to host this buy?
edit: I know a source for EVP-6124, but it's ~$130/10mg, possible cheaper when buying more. Dosage is 0.3-2mg/day.


I have been quoted $34/10mg (not very expensive) for 500mg from a trusted lab, so do you guys want to test agonists for the α7-nicotinic receptor?


]Yes, I want...

#62 bkaz

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Posted 27 January 2014 - 06:41 PM

For EVP or GTS? I'm assuming EVP. Yes; count me in for sure.


Sorry, it was for EVP-6124 yes ;) I really want to try GTS-21, but I'm willing to go with EVP-6124 for now. Don't you think it should at least give us a hint if agonists for the a7 receptor has any future? 500mg was minimum order quantity, so we should at least get a month's supply each. 30mg+ each and no more than 20 participants to not make this more difficult than it needs to be. Personally, I'll probably get 50mg.


Count me in too. What's the half-life?

Around 4h. From what I gather.


Thanks, sounds good.

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#63 aarfai

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Posted 28 January 2014 - 01:10 AM

In for 3 grams

#64 formergenius

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Posted 28 January 2014 - 02:09 AM

In for 3 grams

I'm assuming you mean 3 grams GTS-21? 3 grams EVP-6124 would last you about 4 years...
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#65 aarfai

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Posted 28 January 2014 - 02:26 AM

Hahah I plan on running for presidency in 4 years so I need all the help I can get. Which item have we been quoted on?

#66 formergenius

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Posted 28 January 2014 - 02:32 AM

Lol.. For now the quotation is for EVP-6124.

Edited by formergenius, 28 January 2014 - 02:32 AM.


#67 Mobc1990

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Posted 28 January 2014 - 05:12 AM

I saw1 post of bulk buy people getting scam,the item is not even sent,how do I know it's true?

#68 RAFT LIFE

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Posted 29 January 2014 - 02:15 AM

Hey guys, this is my first post here. Iv been lurking here for quite a while. I am interested in participating in a group buy for either GTS or EVP.

#69 Megatrone

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Posted 29 January 2014 - 08:44 AM

Alright; I suggest you start a new topic with "Group Buy" in the title if you want to take the lead on this one. It'd be nice to have that clearly visible.
I haven't been that scrutinizing, but they seem pretty similar to me. Plus, you might catch more participants with EVP; there are a number of people with schizophrenia on this forum who might be interested in EVP but not in GTS.
My memory sucks, but I think GTS lacked the sensory gating enhancing effects, whereas EVP didn't.

Anyhow; $100 buy-in is reasonable and acceptable. How trusted is the lab? (as in: where is it located?)


The lab is the one NSN uses and is located in China. Everyone OK with this?

Are you sure you don't want to be in charge formergenius? Although I'm a full time student, I will probably step up if nobody else wants to do it. I'd hate to see this group buy not getting anywhere.

$3300/100g , $5500/200G, $7200/300G.


Is this price still accurate?

At 100G, that works out to $33 per gram. If we took the max dosage of 2mg, one gram would work out to 500 doses. To me, this is very good. so we need 33 people to buy 3 grams each. Is this doable?


It it were only so. That quote was for GTS-21, which requires a much higher dose (100mg-450mg daily).

#70 Megatrone

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Posted 29 January 2014 - 03:22 PM

It seems like I'm in charge of this group buy then, if everyone is OK with that. I will open a new group buy thread shortly.
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#71 formergenius

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Posted 29 January 2014 - 04:24 PM

Yes, unfortunately as discussed in PM, I won't be able to coordinate this buy. Thank you for taking the initiative Megatrone. I'm more than OK with using that supplier; I'm sure others will be too.

#72 Megatrone

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Posted 29 January 2014 - 08:13 PM

A new thread for the group buy has been created.

Edited by Megatrone, 29 January 2014 - 08:13 PM.


#73 Megatrone

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Posted 30 January 2014 - 08:15 AM

Does anyone have any suggestion of how we will be dosing? I suspect not everyone (including me) having sufficient equipment to measure out in the 0.1mg range. What would we dissolve it in?

#74 formergenius

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Posted 07 February 2014 - 02:25 AM

Just wondering; does anyone have any input to how this may compare to nicotine in terms of efficacy?
I'm a chronic smoker and have been for several years, and wonder whether a7nAChR agonists are any better than nicotine, or simply "nicotine without the addiction".

#75 Dazzcat

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Posted 11 February 2014 - 03:55 AM

Just wondering; does anyone have any input to how this may compare to nicotine in terms of efficacy?
I'm a chronic smoker and have been for several years, and wonder whether a7nAChR agonists are any better than nicotine, or simply "nicotine without the addiction".


This is exactly what I wondered as well being a smoker (6 months) with my interest in EVP-6124.

After a bit of research i realized that nicotine being a full agonist desensitizes a7nAChR, so with chronic nicotine exposure the cognitive effects would diminish back to baseline and even below baseline during times of low nicotine blood concentrations. A study i read suggested that nicotinic receptors up-regulate from nicotine cessation beyond those of people who have never smoked, causing withdraw symptoms (I believe it was more relevant to the a4b2 receptor).

So I think the only option is to give the brain a rest from nicotine to allow receptors to up regulate and the apply the a7 agonism to see if those much missed cognitive benefits from nicotine can be found again.

Edited by Dazzcat, 11 February 2014 - 04:04 AM.


#76 Reformed-Redan

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Posted 25 April 2014 - 04:21 PM

I'd love to participate in a group buy for this compound.


Seems phenomenal.


 

$3300/100g , $5500/200G, $7200/300G.


Is this price still accurate?

At 100G, that works out to $33 per gram. If we took the max dosage of 2mg, one gram would work out to 500 doses. To me, this is very good. so we need 33 people to buy 3 grams each. Is this doable?

 

 

We could do a spilt with some larger company like Ceretropic or NSN for this compound or suggest it to them and their supplier. We'd be their guinea pigs and they'd estimate efficiency, win win?


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#77 Reformed-Redan

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Posted 25 April 2014 - 04:38 PM

I made a post regarding cooperating with larger entities on reedit here.



#78 Reformed-Redan

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Posted 25 April 2014 - 10:04 PM

Just putting this out there:


Abstract

This study was designed to determine the safety, tolerability, pharmacokinetics and effects on cognitive function of GTS-21 in healthy, male volunteers. A total of 18 subjects were randomized to GTS-21 (25, 75 and 150 mg) or placebo administered three times daily (first 4 days, once on Day 5) for three, 5-day sessions. GTS-21 was well tolerated up to doses of 450 mg/day, with no clinically significant safety findings. C(max) and the area under the plasma concentration of GTS-21 and the metabolite 4-OH-GTS-21 increased in a dose-related fashion; although considerable intersubject variability occurred, it decreased with continued dosing. GTS-21 showed statistically significant enhancement of three measures of cognitive function (attention, working memory, episodic secondary memory) compared to placebo. A relationship between exposure to GTS-21 and the magnitude of the cognitive response was apparent, with maximal effect approached for doses between 75 and 150 mg three times a day. These data indicate that GTS-21 may represent a novel treatment for dementia.

From here

 


Seems effective for ADD also, PI?


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#79 Reformed-Redan

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Posted 25 August 2014 - 06:39 AM

This will be available soon from a trusted supplier soon enough. Keep an eye out. :-D

 

Hoping on making an ER version of this, will see. 


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#80 Metagene

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Posted 25 August 2014 - 07:42 AM

In other words tht lol. Good enough for me.

#81 Megatrone

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Posted 25 August 2014 - 08:06 PM

Good news. Will for sure buy a large quantity upon launch.

 

What I don't understand is why they dosed up to three times a day in the study, when the half life of GTS-21 is 12-24 hours (possibly longer than Modafinil).


Edited by Megatrone, 25 August 2014 - 08:09 PM.


#82 Reformed-Redan

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Posted 26 August 2014 - 07:09 AM

Good news. Will for sure buy a large quantity upon launch.

 

What I don't understand is why they dosed up to three times a day in the study, when the half life of GTS-21 is 12-24 hours (possibly longer than Modafinil).

Unfortunately, the half life is from what I understand somewhere in the ballpark of 4h. So, I might have to resort to just dissolving it in water and sipping away throughout the day.



#83 Megatrone

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Posted 26 August 2014 - 12:36 PM

Then why do they say 12-24 hours here: http://faculty.psy.o...eurosci2011.PDF



#84 Reformed-Redan

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Posted 26 August 2014 - 02:15 PM

Then why do they say 12-24 hours here: http://faculty.psy.o...eurosci2011.PDF

Yes, I read that study. There seems to be some discrepancy with the peripheral effects and cerebral.



#85 VERITAS INCORRUPTUS

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Posted 26 August 2014 - 06:37 PM

Nicotinergic Research: alpha7 nicotinic receptor research (a7nAChR)

TeamTLR is willing to donate four 500mg packs of the following alpha7 partial agonist, Alseventin-OA, for those who have a desire to conduct sound, progressive research with agents of this class.

http://teamtlr.com/t...a-tlr-6124.html

 

Kindly read the complete page if so interested.

Additionally,intranasal ROA within mice models was highly favorable in models applicable to indications for benefit toward cognition and schizophrenia, as well as toward nicotine cessation.

 

From all points within the research we have on hand it appears to be an optimized candidate for said benefits with highest therapeutic index, certainly to perhaps be pursued for further progressive research.

 

If one wishes to make purchase or make some small donation toward TLR and its research of course that is appreciated, but we will as well ship it for free if so desired.  We also will consider discounts on other TLR-OA items, as well as for certain other items, for those with serious progressive research intents.

 

Please contact via the e-mail within the website for further details as would be best to proceed for those so interested.

For those not interested kindly please just ignore this. ;)

 

 

 


Edited by VERITAS INCORRUPTUS, 26 August 2014 - 06:39 PM.

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#86 gizmobrain

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Posted 14 February 2015 - 08:15 PM

First thoughts on the GTS-21: Man this stuff is yellow. Comparable to Riboflavin gold, but more yellowy. Take precautions or you will stain your clothes.

After that... No profound altered state after taking the first dose. Skipped the sublingual route since it seemed to bite the tongue a bit, and all the human dosages test seem to be orally administered anyway.
 

On a completely empty stomach, there was only the slightest bit of uncomfortableness as the capsule dissolved, which seemed to go away in less than 5 minutes. 

 

I've not engaged in any cognition tests as this was just a "let's find out if there are any noticeable mood/body changes" type test. The headache that was there this morning seems to have gone away, but you never can really tell with those things because they come and go so frequently. I seem to be fairly awake and not anxious. 

Anyway, just dropped by to see if anyone else had been involved in testing lately.


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#87 Sunifiramses II

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Posted 16 February 2015 - 04:46 AM

First thoughts on the GTS-21: Man this stuff is yellow. Comparable to Riboflavin gold, but more yellowy. Take precautions or you will stain your clothes.

After that... No profound altered state after taking the first dose. Skipped the sublingual route since it seemed to bite the tongue a bit, and all the human dosages test seem to be orally administered anyway.
 

On a completely empty stomach, there was only the slightest bit of uncomfortableness as the capsule dissolved, which seemed to go away in less than 5 minutes. 

 

I've not engaged in any cognition tests as this was just a "let's find out if there are any noticeable mood/body changes" type test. The headache that was there this morning seems to have gone away, but you never can really tell with those things because they come and go so frequently. I seem to be fairly awake and not anxious. 

Anyway, just dropped by to see if anyone else had been involved in testing lately.

 

What was your dose? Did you experience any more interesting effects later on? I am curious as hell about this stuff, but I would like to see at least one positive experience report before taking the plunge...



#88 gizmobrain

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Posted 16 February 2015 - 11:03 PM

 

What was your dose? Did you experience any more interesting effects later on? I am curious as hell about this stuff, but I would like to see at least one positive experience report before taking the plunge...

 

 

 

I've tried 75mg, 100mg, and 150mg doses.

 

Random notes so far: Feels extremely clean. I generally consume moderate to large quantities of caffeine throughout the day, and have headaches if I do not. This morning, I took 100mg of GTS-21 on an empty stomach, with nothing else. I was alert, awake, and no headache in 15-25 minutes.
 

It does not seem to help me with motivation. I've not found anything yet that stacks with it that will help with motivation either, but I've only tried a few things. I'll post more on combo's as I experiment and verify.

I still haven't set down to evaluate gains in memory and cognitive abilities. My main reason for being here has always been focus and motivation, as I struggle with... well whatever you want to call it (ADHD-PI, anticipatory anhedonia, SCT).

 

Honestly, I hope that a substance like this can get a big break and be a replacement for using/abusing nicotine and caffeine. It feels so much cleaner than both. Unfortunately, the cost + lack of long term or indepth safety profile makes it unlikely to happen anytime soon.

Here's someone else's experience that mimics mine so far:

http://www.reddit.co...gts21_unboxing/

 

 

As for positive effects (mostly subjective), I noticed a clarity of thought that allowed me to complete a number of projects at work that I had been avoiding recently. I also had a couple of co-workers that remarked that I seemed to be a in a lighter/better mood, and was more collaborative, than usual.

 


 


Edited by zrbarnes, 16 February 2015 - 11:07 PM.

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#89 BieraK

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Posted 17 February 2015 - 06:47 PM

This substance needs a lower price and a higher amount, like buy "noopept" or other nootropics.
Perhaps this could stack very well with PRL-8-53 and Coluracetam



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#90 gizmobrain

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Posted 17 February 2015 - 11:35 PM

This substance needs a lower price and a higher amount, like buy "noopept" or other nootropics.
Perhaps this could stack very well with PRL-8-53 and Coluracetam

 

As far as I know, this just hit the consumer market in a very limited fashion. It's actually a quite reasonable price given its "newness". Give it some time... If enough people like it, it will go down in price like Noopept did.

 

I've actually found PRL-8-53 to be the best combo yet. Haven't yet tried it with Coluracetam.







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