sodium butyrate is a HDAC inhibitor which has been shown to increase BDNF (R) Does dietary fiber also do this? Would eating pysillium (?) husks help increase fiber intake?
the HDAC inhibition got me interested in it and i bought 100g of pure sodium butyrate on amazon (pricey). The smell of powder is very potent, but it dissolves in water easily and smell disappears. It has mild sweet/buttery taste. But i noticed no effect even in multigram doses. Neither mental nor GI, weird. Anyone getting any effects from this?
edit: never mind! I found my answers here:
In spite of its early promise, butyrate is not among the drugs used for cancer treatment. The major problem has been to achieve and maintain its millimolar concentrations in blood. Butyrate is metabolized rapidly as soon as it enters the colonocyte via its active transport system (11, 12, 13), and its plasma concentrations are far below those required to exert its antiproliferative/differentiating actions.
A prodrug of natural butyrate, tributyrin, is a neutral short-chain fatty acid triglyceride that is likely to overcome the pharmacokinetic drawbacks of natural butyrate as a drug (14). Because it is rapidly absorbed and chemically stable in plasma, tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing therapeutically effective butyrate over time directly into the cell. Compared with butyrate, tributyrin has more favorable pharmacokinetics (14, 15, 16) and is well tolerated (17). Liquid tributyrin filled into gelatin capsules and administered orally resulted in millimolar concentrations of butyrate both in plasma and inside the cell (17). In vitro, tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects in neoplastic cells (18, 19, 20). In this study, human colon cancer cells (Caco-2) were used to investigate the effects of tributyrin on growth and differentiation."
http://www.longecity...lligence-found/
Edited by jack black, 30 January 2017 - 12:17 PM.