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Butyrate

butyrate

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#1 Skyguy2005

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Posted 02 February 2015 - 03:29 AM


Butyrate. The more I read about this substance the better it seems to be!

 

What supplement sources are there for this susbtance? A google search revealed but a handful...

 

Here's a link to Mark's daily apple on resistant starch (a proven way to raise butyrate levels in the body): http://www.marksdail.../#axzz3QYJ4ZT7v

 

Might be important because it (in supplement form) might not be very bioavailable. On the other hand, here's a link where sufferers of Chrohns disease took it and effects were noticed on NF-KappaB and IL1-Beta: http://www.ncbi.nlm....pubmed/16225487

http://diabetes.diab.../58/7/1509.full



#2 GoingPrimal

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Posted 02 February 2015 - 02:15 PM

If you have a healthy intestinal microflora, fiber and resistance starch would be great choices. 

 

Nature's highest source of butyrate is butter, coming in at 4%. I do notice butter to be a very filling type of fat, and if you're going to start using more butter in your diet I'd suggest any type from local, grass-fed cows, or Kerrygold if you can't find that in your area. 

 

I've also read that it isn't very absorbable in supplement form.. Maybe they'll find a way around that soon as they have with curcumin. I guess for now, it's fiber and butter.



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#3 Mind_Paralysis

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Posted 11 January 2016 - 01:25 AM

Well, damn! I was looking into Butyrate as a form of dietary nootropic - perhaps even to combine with Medium-chain triglyceride fats to create a type of SUPER-CHARGED LCHF -diet.

(even tho', yes, butyrate apparently smells and tastes like PUKE! literally.)

 

However... would Triacetin be a viable replacement?

 

Dietary intake of the short-chain triglyceride triacetin vs. long-chain triglycerides decreases adipocyte diameter and fat deposition in rats.

http://www.ncbi.nlm..../pubmed/7738686

 

According to the study above, rats fed with triacetin became less fat and chubby than their regular-fat fed friends, and suffered no ill effects. How is the bio-availability compared to Butyrate?

 

(for those wondering, triacetin is a compound created from another short-chain: acetate)



#4 IWS

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Posted 11 January 2016 - 08:36 AM

Here a list of foods by butyrate content: http://wholefoodcata...c_acid/foods/1/

 

Butyric acid is also very effective for liver conditions as fatty liver, fibrosis, cirrhosis, etc., cannot find the links right now but they are easily searchable with google, this is about isobutryic acid (an isomer of butryic acid) and inhibition of hepatic stellate cells collagen synthesis: http://digitalcommon...thresources/67/



#5 Adam Karlovsky

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Posted 12 January 2016 - 08:45 AM

http://www.ncbi.nlm....les/PMC2699871/

 

"On the high-fat diet, supplementation of butyrate prevented development of insulin resistance and obesity in C57BL/6 mice. Fasting blood glucose, fasting insulin, and insulin tolerance were all preserved in the treated mice. Body fat content was maintained at 10% without a reduction in food intake. Adaptive thermogenesis and fatty acid oxidation were enhanced. An increase in mitochondrial function and biogenesis was observed in skeletal muscle and brown fat. The type I fiber was enriched in skeletal muscle. Peroxisome proliferator–activated receptor-γ coactivator-1α expression was elevated at mRNA and protein levels. AMP kinase and p38 activities were elevated. In the obese mice, supplementation of butyrate led to an increase in insulin sensitivity and a reduction in adiposity."

http://www.ncbi.nlm....les/PMC3070119/

"These data suggest a wide spectrum of positive effects exerted by butyrate, with a high potential for a therapeutic use in human medicine."

 


I plan on buying, at some point, a wholesale order of magnesium or potassium butyrate. The available supplements are painfully expensive for the amounts one might want for therapeutic effect. And just as a side note, some rough calculations put it as 1g of butyrate = 4.8g fibre that has been healthily fermented in the gut? Popping a few caps of pot/mag butyrate each meal seems like a good way of keeping guts healthy and keeping body fat down, as well as reducing risk of metabolic syndrome.

Few papers mention it, but large doses also seem to significantly reduce blood lipids, which might be good for reducing risk of cardiovascular disease. I'd like to see a longevity study on rats given butyrate. In the mean time, it is, at worst, a waste of money. No risk of toxicity or side effects as far as I am aware, but the potential benefits seem both obvious and of great (dose dependant) magnitude.



#6 Logic

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Posted 12 January 2016 - 11:32 AM

Tributyrin apparently does not stink has other advantages like a long half life IIRC and is dirt cheap here:
http://www.longecity...ndpost&p=744522

I have thought of starting a topic called:
Know any chicken and/or pig farmers? Tributyrin
To see if we can get a hold of this stuff, but haven't yet.
Feel free to do so if you like.

#7 GoingPrimal

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Posted 30 January 2016 - 04:06 PM

Just as an update - I can't attest for any weight loss effects, but I bought some magnesium butyrate based off of this study  showing that it helped decrease excessive alcohol intake in dependent rats.

 

Altogether, our results clearly demonstrated the efficacy of NaB in preventing excessive ethanol intake and relapse and support the hypothesis that HDACi may have a potential use in alcohol addiction treatment.

 

 

I have to say, it worked quite wonderfully. Usually after a few days of not drinking, my mind begins to find ways persuade me to have a few drinks. While using butyrate, at a dose of 3 pills a day (610 mg per pill, 1830 mg per day), any cravings or desire I had to drink practically melted away. I did drink while using it, but felt no desire to continue drinking. In short, there was no desire to drink nor euphoria from doing so.

 

It also has a similar effect on stimulants 

 

I'm out now but would like to buy more and double my dose. If I do, I'll post back with updates, if any.


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#8 stefan_001

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Posted 29 March 2016 - 12:43 PM

Tributyrin apparently does not stink has other advantages like a long half life IIRC and is dirt cheap here:
http://www.longecity...ndpost&p=744522

I have thought of starting a topic called:
Know any chicken and/or pig farmers? Tributyrin
To see if we can get a hold of this stuff, but haven't yet.
Feel free to do so if you like.

 

Perhaps vitamin C could lead to similar effects:

 

Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.

http://www.ncbi.nlm....pubmed/23548903


Edited by stefan_001, 29 March 2016 - 12:44 PM.


#9 stefan_001

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Posted 29 March 2016 - 08:29 PM

 

Tributyrin apparently does not stink has other advantages like a long half life IIRC and is dirt cheap here:
http://www.longecity...ndpost&p=744522

I have thought of starting a topic called:
Know any chicken and/or pig farmers? Tributyrin
To see if we can get a hold of this stuff, but haven't yet.
Feel free to do so if you like.

 

Perhaps vitamin C could lead to similar effects:

 

Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.

http://www.ncbi.nlm....pubmed/23548903

 

 

BTW my interest in butyrate is raising TET1 activity to help maintain methylation patterns.

 



#10 Irishdude

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Posted 02 June 2016 - 10:11 PM

sodium butyrate is a HDAC inhibitor which has been shown to increase BDNF (R) Does dietary fiber also do this? Would eating pysillium (?) husks help increase fiber intake?


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#11 aconita

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Posted 03 June 2016 - 09:01 PM

Short-chain fatty acids, which include butyrate, are produced by beneficial colonic bacteria (probiotics) that feed on, or ferment prebiotics, which are plant products that contain adequate amounts of dietary fiber.

 

https://en.wikipedia.org/wiki/Butyrate

 

Probably inulin would be cheaper and more efficient.


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#12 jack black

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Posted 30 January 2017 - 11:31 AM

sodium butyrate is a HDAC inhibitor which has been shown to increase BDNF (R) Does dietary fiber also do this? Would eating pysillium (?) husks help increase fiber intake?

 

the HDAC inhibition got me interested in it and i bought 100g of pure sodium butyrate on amazon (pricey). The smell of powder is very potent, but it dissolves in water easily and smell disappears. It has mild sweet/buttery taste. But i noticed no effect even in multigram doses. Neither mental nor GI, weird. Anyone getting any effects from this?

 

edit: never mind! I found my answers here:

 

 

In spite of its early promise, butyrate is not among the drugs used for cancer treatment. The major problem has been to achieve and maintain its millimolar concentrations in blood. Butyrate is metabolized rapidly as soon as it enters the colonocyte via its active transport system (11, 12, 13), and its plasma concentrations are far below those required to exert its antiproliferative/differentiating actions.

 

A prodrug of natural butyrate, tributyrin, is a neutral short-chain fatty acid triglyceride that is likely to overcome the pharmacokinetic drawbacks of natural butyrate as a drug (14). Because it is rapidly absorbed and chemically stable in plasma, tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing therapeutically effective butyrate over time directly into the cell. Compared with butyrate, tributyrin has more favorable pharmacokinetics (141516) and is well tolerated (17)Liquid tributyrin filled into gelatin capsules and administered orally resulted in millimolar concentrations of butyrate both in plasma and inside the cell (17). In vitro, tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects in neoplastic cells (181920). In this study, human colon cancer cells (Caco-2) were used to investigate the effects of tributyrin on growth and differentiation."

http://www.longecity...lligence-found/


Edited by jack black, 30 January 2017 - 12:17 PM.

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#13 Mind_Paralysis

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Posted 30 January 2017 - 12:32 PM

 

sodium butyrate is a HDAC inhibitor which has been shown to increase BDNF (R) Does dietary fiber also do this? Would eating pysillium (?) husks help increase fiber intake?

 

the HDAC inhibition got me interested in it and i bought 100g of pure sodium butyrate on amazon (pricey). The smell of powder is very potent, but it dissolves in water easily and smell disappears. It has mild sweet/buttery taste. But i noticed no effect even in multigram doses. Neither mental nor GI, weird. Anyone getting any effects from this?

 

edit: never mind! I found my answers here:

 

 

In spite of its early promise, butyrate is not among the drugs used for cancer treatment. The major problem has been to achieve and maintain its millimolar concentrations in blood. Butyrate is metabolized rapidly as soon as it enters the colonocyte via its active transport system (11, 12, 13), and its plasma concentrations are far below those required to exert its antiproliferative/differentiating actions.

 

A prodrug of natural butyrate, tributyrin, is a neutral short-chain fatty acid triglyceride that is likely to overcome the pharmacokinetic drawbacks of natural butyrate as a drug (14). Because it is rapidly absorbed and chemically stable in plasma, tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing therapeutically effective butyrate over time directly into the cell. Compared with butyrate, tributyrin has more favorable pharmacokinetics (141516) and is well tolerated (17)Liquid tributyrin filled into gelatin capsules and administered orally resulted in millimolar concentrations of butyrate both in plasma and inside the cell (17). In vitro, tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects in neoplastic cells (181920). In this study, human colon cancer cells (Caco-2) were used to investigate the effects of tributyrin on growth and differentiation."

http://www.longecity...lligence-found/

 

 

Tributyrin does seem to be the winner when it comes to these SCFA's - but my curiousity is on a higher level: can a human LIVE OFF OF NOTHING BUT SYNTHETIC SCFA'S?

 

In theory, these compounds function exactly like GLUCOSE in your brain, but without ANY of the trouble-some side-effects - super-charging your metabolism if you feed on nothing but them, slimming you down and increasing available energy-levels for the brain.

 

In theory.

 

But is there actually any tests in humans, and in having the test-subjects cut down on both carbs and regular long-chain fatty acids, and then supplementing with SCFA's? If this actually works, then it could be used to effectively SLIM DOWN terminally obese patients! Without the need for invasive surgery.

 

I have a friend who suffers from intense problems with obesity, and possibly of mild SCT and atypical Autism, and he could desperately need something like this, to not have to go through Gastric Bypass.
 



#14 mrkosh1

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Posted 30 January 2017 - 04:19 PM

Could putting butter in coffee make this substance more bioavailable?



#15 jack black

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Posted 30 January 2017 - 07:56 PM

 

 

But is there actually any tests in humans, and in having the test-subjects cut down on both carbs and regular long-chain fatty acids, and then supplementing with SCFA's? If this actually works, then it could be used to effectively SLIM DOWN terminally obese patients! Without the need for invasive surgery.

 

I have a friend who suffers from intense problems with obesity, and possibly of mild SCT and atypical Autism, and he could desperately need something like this, to not have to go through Gastric Bypass.
 

 

 

Not sure in humans, but in animals butyrate means weight gain with less food:

 

 

Broilers need less feed with butyric acid in diet Using a butyric acid product in broilers can reduce the amount of feed with 2%, while maintaining the same bird growth.

http://www.poultrywo...-diet-2671367W/
 


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#16 Mind_Paralysis

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Posted 31 January 2017 - 09:37 AM

 

 

 

But is there actually any tests in humans, and in having the test-subjects cut down on both carbs and regular long-chain fatty acids, and then supplementing with SCFA's? If this actually works, then it could be used to effectively SLIM DOWN terminally obese patients! Without the need for invasive surgery.

 

I have a friend who suffers from intense problems with obesity, and possibly of mild SCT and atypical Autism, and he could desperately need something like this, to not have to go through Gastric Bypass.
 

 

 

Not sure in humans, but in animals butyrate means weight gain with less food:

 

 

Broilers need less feed with butyric acid in diet Using a butyric acid product in broilers can reduce the amount of feed with 2%, while maintaining the same bird growth.

http://www.poultrywo...-diet-2671367W/
 

 

 

Ey, cheers for the ref'!

 

It certainly confirms that at least in birds, SCFA's can be supplemented as a replacement of sugars, but it's still tricky to see if the same can be done for humans...

 

There are certainly quite a few differences between birds and humans - if we find evidence of the effects on rodents, then that may be more useful though! = )

 

 

Btw, what would you suggest I do, to help my obese friend? I'm asking since I figure you might have some good advice to give, since you are on the spectrum as well as having fought your own battle with over-eating and such things.
 

*Can* I actually do anything? *Should* I do something?



#17 jack black

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Posted 31 January 2017 - 06:40 PM

 

 

 

 

But is there actually any tests in humans, and in having the test-subjects cut down on both carbs and regular long-chain fatty acids, and then supplementing with SCFA's? If this actually works, then it could be used to effectively SLIM DOWN terminally obese patients! Without the need for invasive surgery.

 

I have a friend who suffers from intense problems with obesity, and possibly of mild SCT and atypical Autism, and he could desperately need something like this, to not have to go through Gastric Bypass.
 

 

 

Not sure in humans, but in animals butyrate means weight gain with less food:

 

 

Broilers need less feed with butyric acid in diet Using a butyric acid product in broilers can reduce the amount of feed with 2%, while maintaining the same bird growth.

http://www.poultrywo...-diet-2671367W/
 

 

 

Ey, cheers for the ref'!

 

It certainly confirms that at least in birds, SCFA's can be supplemented as a replacement of sugars, but it's still tricky to see if the same can be done for humans...

 

There are certainly quite a few differences between birds and humans - if we find evidence of the effects on rodents, then that may be more useful though! = )

 

 

Btw, what would you suggest I do, to help my obese friend? I'm asking since I figure you might have some good advice to give, since you are on the spectrum as well as having fought your own battle with over-eating and such things.
 

*Can* I actually do anything? *Should* I do something?

 

 

Long story, i could write a book. The short version is weight is genetically programmed and it's very hard to decrease it a lot and keep it suppressed, short of concentration camp starvation style. But to sound more constructive, it always a good idea to rule out medical causes of obesity like low testosterone or low thyroid or metabolic syndrome, etc. in my case it was low testosterone. since then i lost some 30 lbs but I hit a wall of resistance (incidentally the same weight from my young adulthood) and slowly gaining back.
 


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#18 Mind_Paralysis

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Posted 31 January 2017 - 07:18 PM

Long story, i could write a book. The short version is weight is genetically programmed and it's very hard to decrease it a lot and keep it suppressed, short of concentration camp starvation style. But to sound more constructive, it always a good idea to rule out medical causes of obesity like low testosterone or low thyroid or metabolic syndrome, etc. in my case it was low testosterone. since then i lost some 30 lbs but I hit a wall of resistance (incidentally the same weight from my young adulthood) and slowly gaining back.
 

 

 

All right, I'll have him look into getting some testing for various diseases when I get better, and can bring it up at my peak social ability, with him.

 

Cheers for the advice! = )
 







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