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vitamin e succinate potentiates pge2 anticancer activity

pge2 cancer prostaglandin succinate tocopherol skin hair

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#1 zorba990

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Posted 07 August 2016 - 06:54 PM


This is interesting since overexpression of pge2 is associated with skin cancer proliferation (1)


https://www.research...l_proliferation

Previous studies have shown that prostaglandin E2 (PGE2) and vitamin E succinate can act in an additive manner to inhibit the proliferation of human oral squamous carcinoma cells (SCC-25). The initial studies on the additive anticancer activity of PGE2 and vitamin E succinate have been extended to include antineoplastic PGs, delta 12-PGJ2 and PGJ2. Treatment of oral squamous carcinoma cells (SCC-15) with delta 12-PGJ2, PGJ2, and vitamin E succinate, individually, caused significant concentration-dependent inhibition of cell proliferation to various degrees. PGJ2 was most potent and caused an inhibition that corresponded to 85.55% at 10(-5) M. Addition of 1 microM of vitamin E succinate to delta 12-PGJ2 or PGJ2 resulted in a significant increase in the inhibitory potency of the lower concentrations of the two PGs. These results suggest a novel role for a mixture of PGs and vitamin E as potent antitumor proliferative agents.


(1) http://www.nature.co...l/1209538a.html





Also tagged with one or more of these keywords: pge2, cancer, prostaglandin, succinate, tocopherol, skin, hair

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