It works for me even in small doses, like 100mg. the stuff what I´m using is a 5:1 extract though.
Btw I´m personally experiencing a rebound of monoamines after 1-2 hours roughly.
I guess I know that Youre reffering to the bioavailability of only 2% but I cant tell You much what works but that it works.
On a side not, zizphus jujuba seed extract has helped me more than S. baicalensis in terms of gaba. On the other hand, I had transient anxiogenic effects from it.
I guess the GAD expression could be responsible for that:
Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence
In another study by Ma Yuan et al., over-expression of the α- and γ-subunits of the GABAA receptor and glutamic acid decarboxylase (GAD65/67) in cultured cerebellar granule cells was observed after sanjoinine A (5.0 μM) treatment
http://www.ncbi.nlm....les/PMC4023459/
I would highly suggest this post:
http://www.shaman-au...showtopic=33149
Under "Some plants with compounds, acting on Benzodiazepine-receptors:" You´ll find more suggestions.
One thing that catched my attention was hispidulin because it is seemingly comparable to that of Diazepam, at least on the paper.
The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive effects
Substance concentrations of about 50 nm and higher stimulated the GABA-induced chloride current at all five receptor subtypes (α1−3,5,6β2γ2) investigated (not shown). In contrast to diazepam, hispidulin also enhanced the GABA-activated current at α6β2γ2 GABAA receptors
http://www.ncbi.nlm....les/PMC1575061/
Edited by Flex, 18 January 2016 - 10:58 PM.