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Carbon 60 Hydrated Fullerenes and Cancer

c60 carbon60 c60 hydrated fullerenes chemo cancer

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#1 Walter Derzko

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Posted 22 January 2015 - 04:05 PM


Carbon 60 Hydrated Fullerenes improves the effectiveness and reduces toxicity of Chemo treatment

C60 Fullerene as Synergistic Agent in Tumor-Inhibitory Doxorubicin Treatment
Drugs R D. Dec 2014; 14(4): 333–340.
Published online Dec 12, 2014. doi: 10.1007/s40268-014-0074-4...

Svitlana Prylutska, Iryna Grynyuk, Olga Matyshevska, Yuriy Prylutskyy, Maxim Evstigneev, Peter Scharff, and Uwe Ritter
Joint Ukrainian-German Center on Nanobiotechnology, Kyiv, Ukraine
Taras Shevchenko National University of Kyiv, Volodymyrska Str., 64, Kyiv, 01601 Ukraine
Department of Biology and Chemistry, Belgorod State University, 85 Pobedy Str., Belgorod, 308015 Russia
Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Weimarer Str. 25, Ilmenau, 098693 Germany

Abstract

Background
Doxorubicin (Dox) is one of the most potent anticancer drugs, but its successful use is hampered by high toxicity caused mainly by generation of reactive oxygen species. One approach to protect against Dox-dependent chemical insult is combined use of the cytostatic drug with antioxidants. C60 fullerene has a nanostructure with both antioxidant and antitumor potential and may be useful in modulating cell responses to Dox.

Objective
The aim of this study was to estimate the antitumor effect and antioxidant enzyme activity of combined C60 fullerene and Dox (C60 + Dox) in the liver and heart of mice with Lewis lung carcinoma compared with Dox treatment alone.

Methods
Highly stable pristine C60 fullerene aqueous colloid solution (concentration 1.0 mg/ml, average hydrodynamic diameter of nanoparticles 50 nm) was used in the study and characterized by means of atomic force microscopy (AFM). The in vivo investigation of C60-Dox action was performed via the standard methods of histological and enzyme activity analyses.

Results
Dox (total dose 2.5 mg/kg) combined with C60 fullerene (total dose 25 mg/kg) in tumor-bearing animals resulted in tumor growth inhibition, prolongation of life, metastasis inhibition, and increased number of apoptotic tumor cells and was more effective than the corresponding course of Dox treatment alone. C60 fullerene demonstrated a protective effect against superoxide dismutase and glutathione peroxidase inhibition induced by Dox-dependent oxidative insult in the liver and heart.

Conclusion
Combined treatment with C60 + Dox is considered to be a promising approach for cancer chemotherapy.
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#2 joelcairo

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Posted 29 January 2015 - 08:28 PM

Interesting result because sometimes powerful antioxidants can protect tumor cells from experiencing ROS effects and undergoing apoptosis. If you look at the graphs, tumor growth wasn't vastly inhibited, but after 3 weeks the overall tumor volume was about 33% less in animals receiving Doxorubicin alone and 50% less in animals receiving the combination.

 

Here's a link...

http://link.springer...4-0074-4#page-1

 


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#3 Turnbuckle

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Posted 02 February 2015 - 02:42 PM

Interesting result because sometimes powerful antioxidants can protect tumor cells from experiencing ROS effects and undergoing apoptosis. If you look at the graphs, tumor growth wasn't vastly inhibited, but after 3 weeks the overall tumor volume was about 33% less in animals receiving Doxorubicin alone and 50% less in animals receiving the combination.

 

Here's a link...

http://link.springer...4-0074-4#page-1

 

 

Even more interesting is that C60 was about as effective as the cancer drug, and that the results were additive, suggesting they work by different mechanisms.



#4 Walter Derzko

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Posted 04 February 2015 - 12:08 AM

Israeli Doctors use hydrated fullerenes from Ukraine to successfully treat abdominal cancer-WD

Treatment of cancer of the abdominal cavity ... New technologies

(Via BING Translate; Original Text in Russian below)
4/8/2013, 23:00
Author: Solomon Ki


Carcinosis-cancer of the abdomen, a complex disease, not to mention the danger to life.

Israel has developed an original technique and successfully apply for interfering with abdominal cancer.

Polostnaâ-based operation.

It is not enough.

Operative way deletes all metastases and earlier in the process, became Classics (many of the elements of the methodology were created and tested in Israel), operations to remove tumors.

But then the global schema changes: in Israel, have begun to use the new method.

Abdomen a few hours washed special chemotherapy solution at a temperature of 40 degrees.

Much of this procedure depends on the art of the anesthesiologist: going up the body, and the anesthesiologist should be very careful with 41° of irreversible processes with protein, leading to death.

Moreover, when the temperature is also used a sophisticated algorithm.

However, the effect of recovery from such a washed more than offsets all the complexities and costs of the process.

Physico-chemical and biological properties of the solution are not reported.

It is only known that it used hydrated Fullerenes.

The cost of the operation using the described method, from 50-60 thousand dollars, depending on various factors, including the condition of the patient, his or her age, stage of disease, and many more.
Tags: Cancer, Treatment, abdominal organs, Technology

Original in Russian

http://stop-news.com...tehnologii.html

Лечение рака органов брюшной полости... Новые технологии
8-04-2013, 23:00
Автор: Соломон Ки
Увеличить шрифт A A A

Канцероматоз - рак органов брюшной полости, сложное заболевание, не говоря уже о его опасности для жизни.

В Израиле разработана оригинальная методика и ее с успехом применяют для вмешательства при распространении рака брюшной полости.

В основе - полостная операция.

Без нее – не обойтись.

Оперативным путем удаляются все метастазы – как и ранее в процессе, ставшими классическими (многие элементы методики в свое время созданы и апробированы также в Израиле), выполнения операций по удалению опухолей.

Но затем общемировая схема меняется: в Израиле начали применять новый метод.

Брюшная полость несколько часов промывается специальным химиотерапевтическим раствором при температуре 40 градусов.

Многое при этой процедуре зависит от искусства анестезиолога: происходит нагревание организма, и анестезиолог должен быть очень внимательным - при 41 градусе происходят необратимые процессы с белком, ведущие к летальному исходу.

Более того – при снижении температуры также используется сложный алгоритм.

Однако эффект выздоровления от подобного промывается с лихвой компенсирует все сложности и затраты на этот процесс.

Физико-химические и биологические свойства раствора не сообщаются.

Известно лишь, что в нем используется гидратированный фуллерен.

Стоимость операции с применением описанного метода - от 50-60 тысяч долларов, в зависимости от различных факторов, в том числе – состоянии самого больного, его возраста, стадии болезни и много другого.
Теги: Рак, Лечение, Органы брюшной полости, Технологии

#5 resveratrol_guy

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Posted 09 February 2015 - 01:08 AM

(Via BING Translate; Original Text in Russian below)
 

The question of whether C60HyFn and/or c60oo helps or hurts existing cancer is an issue of major significance. I'm encouraged by your find here, but computerized translation is notoriously untrustworthy. Simple changes in grammar could radically alter the understanding. Anything you can find in English? Or, can anyone here read the Russian and improve the autotranslation?
 

But, thank you for posting this.

 

P.S. I'm tempted to believe that these compounds should be used in concert with 3BP and friends (and perhaps nicotinamide riboside) when treating cancer. But as yet I've not heard of a clinical trial.

 


Edited by resveratrol_guy, 09 February 2015 - 01:14 AM.


#6 Walter Derzko

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Posted 15 February 2015 - 03:21 PM

More results from Carbon 60 Hydrated Fullerenes and Colon/Rectal Cancer -Observational Case Study from conference in Toronto 2000

Symposium "Fullerenes in Biology and Medicine" of 197th Meeting of the American ECS (May 14-18, 2000, Toronto, Ontario, Canada). Abs# 700 (2 p) http://www.electroch...7/pdfs/0700.pdf

First clinical case of treatment of patient (volunteer) with rectal adenocarcinoma by hydrated C60 fullerenes: natural course of the disease or non-specific anticancer activity? G.V. Andrievsky, A.V. Zhmuro, L.V. Zabobonina*.
Institute for Therapy of AMS of Ukraine, Department of Mass Spectrometry, 2-a, Postysheva st.,310039, Kharkov, Ukraine. E-mail: yard@kharkov.ua *- Institute of Medical Radiology of MH of Ukraine, Department of Radiology, 82, Pushkinskaya st., 310002, Kharkov, Ukraine
INTRODUCTION Subject of the report is description of more than 3.5-year-long observation of patient with rectal adenocarcinoma that was treated by C60FWS, namely the molecular–colloid aqueous solutions, containing both single fullerene molecules and their fractal clusters in a hydrated state - [C60@(H2O)m]n [1-4; +Ukrainian patent applications 99084515 (06.08.99) and 99095066 (13.09.99)]. Possibility of administration of hydrated C60 fullerenes in supersmall (homeopathic) doses had been based on the following: - evidences of significant antioxidative, membrane-stabilizing, antiinflammatory and immunomodulative effects of hydrated C60 fullerenes in treatment of experimental pathology [5-7]; - facts on extremely (negligible) low toxicity of fullerenes (for the doses used) [8,9], and absence of mutagenic [10] and carcinogenic properties [11] of these substances; - data on presence of fullerenes in natural sources (e.g. Shungite rocks [12,13]) and on probable participation of supersmall doses of fullerenes in medicinal effects, when people drink the Marcial water (water, that has passed through the Shungite rocks[14]) or take an activated charcoal [15]; - data on possibility of usage of fullerenes as plasmosorbents in treatment of atherosclerosis [16].
RESULTS AND DISCUSSION The patient V.G., 71 years old, in May 1996 had been diagnosed to have rectal adenocarcinoma (T3NxMx, ampular region). In June 1998 the diagnosis had been confirmed morphologically during laparoscopy (T3NxM1P3, stage 4, clinical group IV, liver Mts). In May 1996 the patient refused to receive surgical treatment and, in June 1998, from anticancer chemotherapy. No specific therapy had been administered, except of the course of radiation (-therapy) in a total doze of 61,4 Gy during 07-09.1998 and local symptomatic treatment. As mentioned earlier, the patient voluntarily refused to receive specific anticancer treatment and, from May 1996, received hydrated C60 fullerenes, per os, in supersmall (homeopathic) doses, in a regular way. The total dose of C60 for 3.5 years of treatment has not exceeded 2 mg. At present the main clinical data are the following: the patient is stable; intestinal function is preserved; the patient feel himself quite satisfactorily and is able to work; has no specific complaints; constipation is controlled by laxatives. Two times the patient had been treated from paraproctitis (27.09.99 and 17.11.99). At present, the tumor size measured by means rectoromanoscopy did not change. Regular (once a year, since 1998) computer tomography do not reveal new metastatic foci. Restoration of blood hemoglobin level (Hb, g/L) in the patient are given in Fig.1. It is well known that natural course of the oncologic disease, as a strong rule, leads to serious decrease in Hb level, and we observed the opposite direction of changes. Note that the administration of hydrated C60 fullerenes at the period of -therapy was connected with quick restoration of Hb level. Although, in this clinical situation, there is not enough data for understanding of cause-effect relationships, one can hypothesize that antioxidative, membrane-stabilizing and radioprotective effects of hydrated fullerenes could facilitate to restoration of erythropoesis and protection of liver function.
We also has data on some other cases of hydrated C60 fullerenes’ efficacy in patients-volunteers with nontreatable (not subject to surgery) pancreatic carcinoma, lung cancer, multiple myeloma. The criteria of treatment efficacy (meant for all these cases) were: clinical signs and symptoms; tumor size and/or growth rate; life expectancy; Hb blood level. In these cases there had been registered «smoothing» of symptoms, clinically significant analgetic and antiinflammatory action, tendency to normalization of blood Hb level and ESR (the erythrocytes sedimentation rate).
Our results, from the point of view of generally accepted international standards of drug testing (GMP, GLP, ICH GCP), can not be viewed as (and do not pretend to be) a well-based scientific evidence of specific anticancer efficacy of hydrated fullerenes. The obvious limitations of this clinical report are connected with insufficient (both clinically and statistically) number of cases described; the fact that the natural course of the disease, as well as placebo effect, could be responsible for the changes observed. But the facts described permit to test hypotheses on these effects during experimental pharmacological studies and, later on, in clinical drug trials in oncology, may be also as an additional therapy. As the actions of hydrated C60 fullerenes are seen when using supersmall doses of the substance, the initial approaches for clinical investigation of C60FWS may be similar to those in development of homeopathic medicines. ACKNOWLEDGMENTS The authors thank Dr. R.O. Loutfy, President of MER Corporation (Tuscon, AZ, USA), for kindly providing of fullerene samples.

REFERENCES 1. G.V. Andrievsky, M.V. Kosevich, O.M. Vovk, V.S. Shelkovsky and L.A.Vashchenko. ON THE PRODUCTION OF AN AQUEOUS COLLOIDAL SOLUTION OF FULLERENES. J.Chem.Soc., Chem. Commun., 12, 1281 (1995). 2. G.V. Andrievsky, M.V. Kosevich, O.M. Vovk, V.S. Shelkovsky and L.A. Vashchenko. ARE FULLERENES SOLUBLE IN WATER? in: Chemistry and Physics of Fullerenes and Related Materials/1995, R.S.Ruoff and K.M.Kadish, Editors, PV 95-10, p.1591, The Electrochemical Society Proceedings Series, Pennington, NJ (1995). 3. G.V. Andrievsky, V.K. Klochkov, E.L. Karyakina and N.O. Mchedlov-Petrossyan. STUDIES OF AQUEOUS COLLOIDAL SOLUTIONS OF FULLERENE C60 BY ELECTRON MICROSCOPY. Chem.Phys.Lett., 300, 392 (1999). 4. G. V. Andrievsky, V. K. Klochkov and L. I. Derevyanchenko. FWS - MOLECULAR–COLLOID SYSTEMS OF HYDRATED FULLERENES AND THEIR FRACTAL CLUSTERS IN WATER SOLUTIONS. Book of Abstracts, 195-th Meeting of The Electrochemical Society ( May 2-6, 1999, Seattle, Washington) Abs# 710. 5. G. V. Andrievsky, A. D. Roslyakov and V. K. Klochkov. MOLECULAR–COLLOID SYSTEMS OF FULLERENES IN WATER AS PROTOTYPES OF THE NEW CLASS OF PHARMACEUTICALS. Ibid., Abs# 689. 6. A.D. Roslyakov, G.V. Andrievsky, A.Yu. Petrenko and L.T. Malaya. CYTOTOXIC AND ANTIOXYDANT PROPERTIES OF WATER SOLUTIONS OF THE NATIVE FULLERENES ON IN VITRO MODELS. Zh.Akad.Med.Nauk Ukrainy (Russ.), 5, 338 (1999). 7. A.D. Roslyakov, G.V. Andrievsky and L.T. Malaya. INTERACTION OF THE HYDRATED FULLERENE С60 WITH PLASMATIC MEMBRANE OF RED BLOOD CELLS. Book of Abstracts of The 4 th Biennial International Workshop in Russia "Fullernes and Atomic Clusters" (IWFAC'99, October 4 - 8, 1999, St. Petersburg, Russia) p.307. 8. L.A Mukovsky, P.P Iakoutseni, Yu.A. Lybimov G.S. Stroykova and L.S. Salova. THE TOXICOLOGICAL CHARACTERISTICS OF FULLERENES. Book of Abstracts of The Second International Workshop in Russia "Fullerenes and Atomic Clasters" (June 1924, 1995, St.Petersburg) p. 173. 9. A.W Jensen., S.R. Wilson and D.I. Schuster. BIOLOGICAL APPLICATIONS OF FULLERENES - A REVIW. Biorg. Med. Chem. 4, 767 (1996). 10. L.P Zakharenko, I.K. Zakharov, S.N. Lunegov and A.A. Nikiforov. DEMONSTRATION OF THE ABSENCE OF GENOTOXICITY OF FULLERENE C60 USING THE SOMATIC MOSAIC METHOD. Dokl.Akad.Nauk (Russ). 335, 261 (1994). 11. M.A. Nelson, F.E. Domann, G.T. Bowden S.B. Hooser; Q. Fernando; and D.E. Carter. EFFECTS OF ACUTE AND SUBCHRONIC EXPOSURE OF TOPICALLY APPLIED FULLERENE EXTRACTS ON THE MOUSE SKIN. Toxicol. Ind. Health. 9, 623 (1993). 12. S.V. Kholodkevich, A.V. Bekrenev, V.K. Donchenko, V.I. Domoroschenkov, O.I. Kon'kov, V.V. Poborchiy, E.I. Terukov, I.N. Trapeznikova. ISOLATION OF NATIVE FULLERENES FROM SHUNGITES OF KARELIYA. Dokl.Akad.Nauk. (Russ), 330, 340 (1993). 13. N.N. Rozhkova, G. V.Andrievsky, L.I. Derevyanchenko, V.K. Klochkov and E. Shulyakovskaya. FULLERENES IN SHUNGITE CARBON. EXTRACTION OF FULLERENES BY WATER-CONTAINING SOLVENTS. International Conference «Eurocarbon 2000», Berlin, July, 2000 (accepted). 14. S.A.Vishnevskiy, MEDICAL TERRAIN OF KARELIYA, p.57, GI KaASSR, Petrozavodsk (1957). 15. M. Shibuya, M. Kato, M. Ozawa, P.H. Fang, E.Хsawa. DETECTION OF BUCKMINSTERFULLERENE IN USUAL SOOTS AND COMMERCIAL CHARCOALS. Fullerenes Sci. and Technol., 7, 181 (1999). 16. V.M. Sedov Yu.M. Andozkaja, N.A. Podossenova, A.S. Kuznetsov. INVESTIGATION OF ADSORPTION PROPERTIES OF FULLERENE PLASMOSORBENT. ExConsilio, 2, 104 (1998).


Figure 1. Restoration of blood hemoglobin (Hb) level after laparoscopy (20.05.98) and course (30.06-27.07.98 and 11.08-02.09.98) of -therapy in the patient with rectal adenocarcinoma (T3NxM1P3) under treatment by supersmall doses of hydrated C60 fullerenes.

#7 Walter Derzko

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Posted 15 February 2015 - 03:38 PM

Misfolded proteins could be regulated by Carbon 60 Hydrated Fullerenes

The unfolded protein response as a target for cancer therapy / misfolded proteins may be corrected and mediated by Carbon 60 Hydrated Fullerenes

-----Original Message-----
From: Grigoriy Andrievsky]
Sent: February 15, 2015 9:13 AM
To: Walter Derzko
Subject: Re: The unfolded protein response as a target for cancer therapy.

Дійсно, так. Це один з ймовірних механізмів його протиракрвої дії через вплив на структури води.
Translation
Indeed, yes. This is one of the possible mechanisms of its action through anti-cancer effects due to structured water (around C60).

Walter Derzko wrote 15.02.2015 03:13:
> Sounds like C60 HYFNs could well regulate this- misfolded proteins -WD
>
> Biochim Biophys Acta. [1] 2014 Dec;1846(2):277-84. doi:
> 10.1016/j.bbcan.2014.07.006. Epub 2014 Jul 25.
>
> THE UNFOLDED PROTEIN RESPONSE AS A TARGET FOR CANCER THERAPY.
>
> Nagelkerke A [2]1, Bussink J [3]2, Sweep FC [4]3, Span PN [5]4.
>
> AUTHOR INFORMATION [1]
>
> * 1Department of Laboratory Medicine, Radboud University Medical
> Center, Nijmegen, The Netherlands; Department of Radiation Oncology,
> Radboud University Medical Center, Nijmegen, The Netherlands.
> * 2Department of Radiation Oncology, Radboud University Medical
> Center, Nijmegen, The Netherlands.
> * 3Department of Laboratory Medicine, Radboud University Medical
> Center, Nijmegen, The Netherlands.
> * 4Department of Radiation Oncology, Radboud University Medical
> Center, Nijmegen, The Netherlands. Electronic address:
> Paul.Span@Radboudumc.nl.
>
> ABSTRACT
>
> Various physiological and pathological conditions generate an
> accumulation of misfolded proteins in the endoplasmic reticulum (ER).
> This results in ER stress followed by a cellular response to cope with
> this stress and restore homeostasis: the unfolded protein response
> (UPR). Overall, the UPR leads to general translational arrest and the
> induction of specific factors to ensure cell survival or to mediate
> cell death if the stress is too severe. In multiple cancers,
> components of the UPR are overexpressed, indicating increased
> dependence on the UPR. In addition, the UPR can confer resistance to
> anti-cancer treatment. Therefore, modification of the UPR should be
> explored for its anti-cancer properties. This review discusses factors
> associated with the UPR that represent potential therapeutic targets.
>
> Copyright © 2014 Elsevier B.V. All rights reserved.
>
> KEYWORDS:
>
> Autophagy; Cancer; Endoplasmic reticulum stress; Therapy; Unfolded
> protein response
>
> http://www.ncbi.nlm....pubmed/25069067[1]

#8 Logic

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Posted 16 February 2015 - 10:33 AM

How to make your own C60HYFN by bcelliott - Ph.D. on fullerenes:


[This is my first post on the forum (I've been lurking), so take it easy on me! My background--got my Ph.D. working on fullerenes. I synthesized them in arc reactors that we built, extracted them from soot, purified them, and studied their electronic structure and reactivity with many methods. So I do have some background in the area.

We ran into Andrievsky, the guy who has done the lion's share of work on hydrated fullerenes, at a conference in 2003 in St. Petersburg Russia. At that time, he was preaching the gospel of HyFn to the extent of carrying around vials of concentrated HyFn in his shirt pocket and showing and telling to anyone who would listen that the stuff would cure all ills. I was asked by my prof to reproduce his results, so I made a lot of his stuff and characterized it by spectroscopy, dynamic laser scattering, electron microscopy, etc. My results matched Andrievsky's, so I was convinced. Took one tiny swig of the stuff back then but didn't have the guts to try more. I also reproduced the THF into water method as well.

Fast forward to this last month. A large rat aquaintance of mine has had acute gall bladder problems, and cannot digest most oils, so dosing with C60-OO is not an option. I dusted off Andrievsky's method and made about 250 ml of semi-concentrated HYFN for him. He will begin taking it within days, so we'll see if it has any positive effects.

The method is fairly straightforward, though you need a horn ultrasonicator for best results. Without getting into the nitty gritty details, a layer of low to medium concentrated filtered C60-toluene solution is layered on top of a much larger volume of water, and directly sonicated near the interface for several hours while controlling the temperature. The sonic energy should not be too high or you'll lose too much product to a hard-to-separate emulsion. You can either wait until the toluene evaporates or use a separation funnel to recover the aqueous portion, which is yellow. Then you filter, concentrate as you wish, and filter again. If done correctly, the solution should be yellow and transparent, since most of the product will be tiny clusters of water-complexed C60 from 1-3 molecules, with a small percentage as larger clusters. The THF method (which is the only one to show toxic effects in organisms) and other methods such as direct mixing into water yield much larger clusters from 30-200 nm in size. The sonication from toluene method seems to be the best to produce bioavailable, non-toxic product since the single fullerenes are already fully solvated by toluene at relatively low concentrations in that solvent, and the sonic energy simply exchanges the solvent for water.

Buying second-hand lab equipment to make this product is far less expensive than buying it from Ukraine! It is a lot more work than C60-OO, however, and what remains to be seen is if there are advantages to the HyFn when compared with the oil-solubilized version.
http://www.longecity...fullerene-hyfn/


A cheap sonicator:
http://www.artisticd....com/ulfog.html


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#9 Walter Derzko

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Posted 16 February 2015 - 02:53 PM

Fat chance that the average quy on the street is going to make their own fullerenes. He has never even seen a testtube in his life. You are dreaming in technicolour
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#10 Logic

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Posted 16 February 2015 - 03:44 PM

Fat chance that the average quy on the street is going to make their own fullerenes. He has never even seen a testtube in his life. You are dreaming in technicolour

 
True, but this is Longecity.  People here aren't 'the average quy on the street' and many are already making their own C60oo and Lyposomally Encapsulated supps with sonicators.
http://www.longecity...l-and-curcumin/
So many have sonicators already and Toluene is easily accessible as a quick Google search proves.

Your posts haven't made it overtly obvious that you are advertising a product... Until now..!
I wish you the best with your venture and suggest Facebook and Twitter as possibly effective marketing tools.
:)

Edited by Logic, 16 February 2015 - 03:56 PM.

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#11 Walter Derzko

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Posted 16 February 2015 - 04:09 PM

Why go to that trouble and wasted time on one-to-one marketing? Manufacturers will soon be producing this on mass and mass marketing it as a ultra high Universal antioxidant once it gets regulatory GRAS approval. My reason for being on Longecity has nothing to do with sell or marketing anything. It's getting valuable feed back from people like you. Thanks ever so much for obliging.

Edited by Walter Derzko, 16 February 2015 - 04:15 PM.


#12 Kalliste

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Posted 16 February 2015 - 04:58 PM

Your posting here is erratic. Create one thread and post every study about HyFn there. I'm interested.



#13 Walter Derzko

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Posted 16 February 2015 - 07:27 PM

Quote: Create one thread and post every study about HyFn there. I'm interested.

Cosmicalstorm; Most of the academic publications on Carbon[60] hydrated fullerenes can be found on Research Gate

https://www.research...le/G_Andrievsky

#14 niner

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Posted 16 February 2015 - 08:36 PM

Fat chance that the average quy on the street is going to make their own fullerenes. He has never even seen a testtube in his life. You are dreaming in technicolour

 

No one makes their own fullerenes.  Everyone (including Andrievsky, I suspect) buys fullerenes from one of the well-known producers of them.  Then all you have to do is mix them with an appropriate amount of olive oil and stir, if you want to make c60oo.  If you want to make HyFn, you make a toluene solution, float it on water and sonicate it, then separate, concentrate, and filter the aqueous layer.   HyFn production certainly requires more lab skills than c60oo, but I don't think it's beyond the capabilities of a number of people here.  Considering the cost per milligram of fullerene for a product like IAPCOM's Water of Life, a knock-off product seems like a money-making proposition.  With all the quasi-advertising you're doing here, you might encourage someone in that direction.  I'd hate to see someone violate any patents, but you know how crazy the Internet is...


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#15 Logic

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Posted 16 February 2015 - 11:13 PM

Why go to that trouble and wasted time on one-to-one marketing? Manufacturers will soon be producing this on mass and mass marketing it as a ultra high Universal antioxidant once it gets regulatory GRAS approval. My reason for being on Longecity has nothing to do with sell or marketing anything. It's getting valuable feed back from people like you. Thanks ever so much for obliging.


My pleasure Walter. :)

Tell me; did Andrievsky file the US patent..?

Edited by Logic, 16 February 2015 - 11:14 PM.


#16 Logic

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Posted 16 February 2015 - 11:19 PM


Your posting here is erratic. Create one thread and post every study about HyFn there. I'm interested.

69 papers can be found in the same thread linked to earlier, started by me 2.5 years ago:
http://www.longecity...ndpost&p=523477

Not bad for someone 'ill informed', now is it Walter!? :)


Edited by Logic, 16 February 2015 - 11:30 PM.

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#17 Walter Derzko

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Posted 16 February 2015 - 11:19 PM

Yes the patent for Carbon 60 hydrated fullerenes is patent pending and the patent application was accepted March 2014 by the USPO

Edited by Walter Derzko, 16 February 2015 - 11:23 PM.


#18 Logic

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Posted 16 February 2015 - 11:25 PM

 

Fat chance that the average quy on the street is going to make their own fullerenes. He has never even seen a testtube in his life. You are dreaming in technicolour

 
No one makes their own fullerenes.  Everyone (including Andrievsky, I suspect) buys fullerenes from one of the well-known producers of them.  Then all you have to do is mix them with an appropriate amount of olive oil and stir, if you want to make c60oo.  If you want to make HyFn, you make a toluene solution, float it on water and sonicate it, then separate, concentrate, and filter the aqueous layer.   HyFn production certainly requires more lab skills than c60oo, but I don't think it's beyond the capabilities of a number of people here.  Considering the cost per milligram of fullerene for a product like IAPCOM's Water of Life, a knock-off product seems like a money-making proposition.  With all the quasi-advertising you're doing here, you might encourage someone in that direction.  I'd hate to see someone violate any patents, but you know how crazy the Internet is...

 

:-D
 



#19 Logic

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Posted 16 February 2015 - 11:29 PM

Yes the patent for Carbon 60 hydrated fullerenes is patent pending and the patent application was accepted March 2014 by the USPO

 

Would y0ou be so kind as to provide a link or patent # as I don't seem to be able to find the application.
 



#20 Walter Derzko

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Posted 17 February 2015 - 12:05 AM

Yes the patent for Carbon 60 hydrated fullerenes is patent pending and the patent application was accepted March 2014 by the USPO

 
Would y0ou be so kind as to provide a link or patent # as I don't seem to be able to find the application.


No worries Logic .... http://www.freepaten...14/0079746.html

FULLERENES AND OTHER CAGE MOLECULAR STRUCTURES IN A SPECIAL HYDRATED STATE
United States Patent Application 20140079746

#21 jroseland

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Posted 15 February 2019 - 11:20 AM

Can anyone link me to anecdotes of people who used C60 to treat cancer?



#22 treonsverdery

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Posted 19 August 2020 - 03:35 AM

The senolytic drug combination Dasatinib + Quercetin is likely pretty well known here.  Noting that Dasatinib is a chemotherapy drug do you think it could amke sense to skip C60 for a week before a Dasatinib + Quercetin treatment?


Edited by treonsverdery, 19 August 2020 - 03:36 AM.


#23 joesixpack

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Posted 20 August 2020 - 04:13 AM

The senolytic drug combination Dasatinib + Quercetin is likely pretty well known here.  Noting that Dasatinib is a chemotherapy drug do you think it could amke sense to skip C60 for a week before a Dasatinib + Quercetin treatment?

I am not a Doctor. I do not think C60 has an affect on cancer. However, some have connected good things from taking EVOO. So, if cancer is a concern, skip the C60 and take a teaspoon of EVOO a day. The rats in the experiment did well on on it.



#24 jroseland

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Posted 12 November 2020 - 01:46 PM

I've got my hands on some C60/cancer science that I don't think has been discussed here. I'll link the studies' PDFs here, I haven't founded them elsewhere online so perhaps this is something that I'm "breaking."

 

There are well over 40 scientific papers and studies evaluating the C60’s anti-cancer effects. But some of the most promising research is not published, I’ll delve into it here...

 

I’m a big fan of free-market science, and there’s a collection of in vivo C60 animal studies done by LivePet, LLC of Austin, Texas wherein these sarcomas...

Human Pancreatic Cancer BxPC-3-GFP

Human Prostate Cancer PC-3-GFP

Canine Osteosarcoma D-17 Cell Line

Were treated in lab rats with C60, as documented here. The trials are summarized...

In only one case of the three, namely canine osteosarcoma, was a serum able to completely eradicate the cancer and seemingly prevent regrowth of any further masses. The most compelling point of notes is not that the serum was able to eliminate a malignant tumor, as many chemotherapy agents are able to perform the same task, but that it was achieved using [C60 serum] that enhanced the mouse's overall physical resilience, immune system response and longevity.

So in all three trials 4-6 weeks of serum therapy put the cancer into retreat and it eradicated the osteosarcoma.

 

Ian Mitchell, the lead researcher of these studies with different types of cancer (sarcomas, carcinomas, lymphomas), reported in an interview:

“We’ve worked with over 20 different cancers and had great responses with all of them...” and C60!

 

And, I know what the skeptic might be thinking...

So this company that sells C60 for pets funded science that demonstrates that their product “cures cancer” - seems like they might have a bit of a conflict of interest there...

Sure, this gets at deeper philosophical questions about human nature, institutions, power, authority, and morality. You get what you pay for, so somebody needs to pay for science. Publicly-funded science tends to be hamstrung by perverse political influence. University-funded science is at the mercy of the petty politics of accademia which is often deeply-dogmatic. 

If I was elected “World Emperor of Science,” I would take a more libertarian approach and fund science solely via crowdfunding; interested citizens would select scientific projects that appealed to them to fund out of their own pockets. But I would demand some skin in the game on behalf of the scientists, scientists would be required to cover 10%-25% of the cost of the science out of their own funds.

Science being conducted and funded by small or medium-sized businesses headed by scientists like Ian Mitchell, that develop products based upon that science is not far off from the voluntaryist/libertarian ideal that I imagine.

To fully understand why I see free-market, privately-funded science as more (or at least, equally) credible than that funded by the taxpayers, universities, and big pharma, you’d want to read my book review of Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions and familiarize yourself with the philosophy of Nassim Taleb.



#25 Mind

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Posted 12 November 2020 - 06:10 PM

I've got my hands on some C60/cancer science that I don't think has been discussed here. I'll link the studies' PDFs here, I haven't founded them elsewhere online so perhaps this is something that I'm "breaking."

 

There are well over 40 scientific papers and studies evaluating the C60’s anti-cancer effects. But some of the most promising research is not published, I’ll delve into it here...

 

I’m a big fan of free-market science, and there’s a collection of in vivo C60 animal studies done by LivePet, LLC of Austin, Texas wherein these sarcomas...

Human Pancreatic Cancer BxPC-3-GFP

Human Prostate Cancer PC-3-GFP

Canine Osteosarcoma D-17 Cell Line

Were treated in lab rats with C60, as documented here. The trials are summarized...

In only one case of the three, namely canine osteosarcoma, was a serum able to completely eradicate the cancer and seemingly prevent regrowth of any further masses. The most compelling point of notes is not that the serum was able to eliminate a malignant tumor, as many chemotherapy agents are able to perform the same task, but that it was achieved using [C60 serum] that enhanced the mouse's overall physical resilience, immune system response and longevity.

So in all three trials 4-6 weeks of serum therapy put the cancer into retreat and it eradicated the osteosarcoma.

 

Ian Mitchell, the lead researcher of these studies with different types of cancer (sarcomas, carcinomas, lymphomas), reported in an interview:

“We’ve worked with over 20 different cancers and had great responses with all of them...” and C60!

 

And, I know what the skeptic might be thinking...

So this company that sells C60 for pets funded science that demonstrates that their product “cures cancer” - seems like they might have a bit of a conflict of interest there...

Sure, this gets at deeper philosophical questions about human nature, institutions, power, authority, and morality. You get what you pay for, so somebody needs to pay for science. Publicly-funded science tends to be hamstrung by perverse political influence. University-funded science is at the mercy of the petty politics of accademia which is often deeply-dogmatic. 

If I was elected “World Emperor of Science,” I would take a more libertarian approach and fund science solely via crowdfunding; interested citizens would select scientific projects that appealed to them to fund out of their own pockets. But I would demand some skin in the game on behalf of the scientists, scientists would be required to cover 10%-25% of the cost of the science out of their own funds.

Science being conducted and funded by small or medium-sized businesses headed by scientists like Ian Mitchell, that develop products based upon that science is not far off from the voluntaryist/libertarian ideal that I imagine.

To fully understand why I see free-market, privately-funded science as more (or at least, equally) credible than that funded by the taxpayers, universities, and big pharma, you’d want to read my book review of Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions and familiarize yourself with the philosophy of Nassim Taleb.

 

I see a lot of cases where a company makes a product, it has some positive effect, then skeptics ask questions. They don't believe it so the company pays for a study. Then after the study people say it doesn't count because the company funded it. Kind-of like damned-if-you-do, damned-if-you-don't. The skeptics are never going to pony up the money for studies, so it is left up to the companies in most cases.


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#26 treonsverdery

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Posted 03 January 2021 - 11:07 PM

It looks like the research (2020) points different ways for lognevity and C60.  The Baati study has the rats living 90% longer.  A newer study, with a larger number of rodents shows no effect.  Malonic acid C60 is patented as a longevity agent and makes mice live about 27% longer.  There is a study on fungi where C60 is (30 someting%? longevizing)

 

This study says no effect on mice: https://link.springe...357-020-00292-z

 

But Baati's test organism was rats so they should try C60 on rats again, and age batched groups of marmosets (a primate with 15 year lifespan).  Say 3 marmosets each at age 14,12,11,8 and then let the cohorts age out to see if they live longer.

 

 

C60 improves the well being of algae (doubles growth), fungie (30something longevity increase) and daphnia, so the data trend is 4-5 studies noting benefit of C60 to one in mice with no benefit.  

 

 

Also, C60 malonic acid variants are highly active as antioxidants, Making mice with thie antioxidant SOD genes knocked out live 300% longer. https://www.scienced...891584904005416

 

Well Normal mice Live about 27% longer from malonic acid decorated C60. (Dugan patent)

 

Here is an image of Mouse (metazoan) lifespan from C60-malonic acid oral supplementation from the Dugan patent.  The source is the patent on life extension of metazoans, https://patents.goog...0030162837A1/en Glancing at the graphic it looks like malonic acid makes mice live about 27% longer.  The C60 product is C3 malonic acids attached at thre locations on a C60 fullerene.

 

US20030162837A1-20030828-D00004.png

 


Edited by treonsverdery, 03 January 2021 - 11:26 PM.






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