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Geroprotector review: Rapamycin

Posted by s123 in Sven's Science Column, 18 July 2017 - * * * * * · 4,636 views
rapamycin

Geroprotector review: Rapamycin Rapamycin and other mTOR inhibitors as geroprotectors

This article is solely for information purposes, not a substitute for professional medical or dietary advice. The provisos of the LongeCity user agreement apply. 





What: A drug to prevent rejection of transplanted kidneys. Also used in cancer therapy. Various related comp...
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Transplanted microglia - where did they go?

Posted by Mondey in Microglia Stem Cells, 10 May 2017 - - - - - - · 1,003 views
microglia therapy

Hi,
yes it has been a while since I wrote something here.  Here are two papers pusblished including the work funded by you:
Leovsky C, Fabian C, Naaldijk Y, Jäger C, Jang HJ, Böhme J, Rudolph L, Stolzing A. Biodistribution of in vitro-derived microglia applied intranasally and intravenously to mice: effects of aging. Cytotherapy. 2015 Nov;17(11):1617...
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CellAge fundraiser support

Posted by caliban in Longecity Blog, in News 28 January 2017 - * * * * * · 2,687 views
fundraiser, cellage

CellAge fundraiser support UPDATE Feb.9th 2017: success!







LongeCity.Org has decided to support the current CellAgeFundraiser initiative beyond its standard support for certified ‘star-rated’ community fundraiserthrough an extension of its affiliate labprogramme. To this end we have identified a specific small ‘sub goal’ withinthe first work project...
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Why I Hate Citing References.

Posted by YOLF in YOLF's Blog, 19 August 2017 - - - - - - · 92 views
citations

References are Expensive:
You know what I hate about using references? Sometimes it's just too many damn references to explain what I'm talking about or how I arrived at it. Do you mean to call me a liar? Do you want a complete course in this stuff? It would literally take 2-3 hours a post to find and quote everything I'm talking about and then meticulo...
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Could policy revisions lead to a healthier nation?

Posted by YOLF in Opinions on Weight Loss, 26 July 2017 - - - - - - · 310 views
weight loss

So, I was reading this over at the FDA and it dawned on me that these safety side effects were only likely to occur in people who are aged. In young people, it would very likely not be an issue. So here's the bigger issue: 
If you take these away from young people or dissuade them from using them altogether, the young people will lose the opportunit...
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Geroprotector review: Metformin

Posted by s123 in Sven's Science Column, 18 July 2017 - * * * * * · 5,979 views
metformin, geroprotector and 3 more...

Geroprotector review: Metformin Geroprotector review: Metformin
Sven Bulterijs  
This article
- is a summary - The full version can be downloaded here:
- is a 2017 (spring) update - See here for a 2011 article on metformin by the Author.
- is solely for information purposes , not a substitute for professional medical or dietary advice. The provisos of the LongeCity us...
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win$100 for 'best regimen'

Posted by caliban in Longecity Blog, 09 June 2017 - - - - - - · 876 views
competition

win$100 for 'best regimen' The forum structure at the heart of LongeCity works well in facilitating a free flow of communication and information exchange.
Other more structured ways of curating information have their own advantages, but their adoption appears to be more difficult.  In 2014 we closed the 'regimen' forums for brain enhancement and general supplements in favou...
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Shalots

Posted by caliban in caliban's Blog, 18 May 2017 - - - - - - · 1,039 views
venting

Shalots “ Shalot ” = a made-up word for a type of person active in life extension, cryonics, artificial intelligence and related fields. Sometimes encountered on LongeCity.  The word is a constriction of ‘zealot’ and ‘shallow’ and also a reference to Tennyson’s poem ‘the Lady of Shalott’ (2x’t’) as someone who is removed from the real world, obsessed with...
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How to Manufacture the Greatest Sleep of Your Life (Part 1)

Posted by gill3362 in Practical Longevity, 11 May 2017 - - - - - - · 1,120 views
sleep, rem sleep, metabolism and 7 more...

To Sleep Is to Live
Sleep is the single most underestimated ingredient impacting your health and life. Sleep is so powerful, in fact, that making even tiny improvements to this activity we spend ⅓ of our time doing can radically improve the quality of our health and our lives.
This post (part 1 of 2, so stay tuned) will introduce you to the basics of h...
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Healthy smoothie life

Posted by nootrope in nootrope's Blog, 27 March 2017 - - - - - - · 1,155 views
supplements, exercise, smoothies

Life continues! 
Although in many ways I'm quite healthy (knock on wood), and looking at Facebook pictures of my classmates from high school and college, I find they often look a decade plus older than I am--in some ways too being a health nut might not be ultimately so healthy. It could be a way of postponing my life. Instead of seizing the day, I j...
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More Planet Fitness Coolness

Posted by YOLF in Working Out, 18 February 2017 - - - - - - · 985 views
coolness

I happened to notice a Red Light Therapy room among the tanning rooms at Planet Fitness yesterday. As many will have read here on the forum, there is lots of support for for 650nm (red) light and producing collagen and not only this, but it's not tanning, it doesn't use wavelengths which are known to cause cancer. So planet fitness is apparently helping u...
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Abaloparatide

Posted by Darkly Origins in Eerie Flickering (Darkly Origins), 11 January 2017 - - - - - - · 1,260 views
nootropics, newtropics and 7 more...

I am looking for a person(s) to provide me with the right acquaintances, or to otherwise help me ascertain at minimal, a month supply of a drug undergoing trials yet; the name of the drug is called "abaloparatide." Any and all referential mention, documentation, information and details about the drug will be greatly appreciated. If you are so kindly inter...
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Nicotinamide Riboside - Some Notes

Posted by Anthony_Loera in Bit o' Research, 23 November 2016 - - - - - - · 1,519 views
rgnr, nice ruffles

NR - Nicotinamide Riboside NR activates SIRT2 ? (hmm not sure, I got to re-listen again)
NR one of 3 precursors to NAD
Out of the 3 precursors NR takes the least amount of ATP to make NAD, so if you have low ATP. in your system.. not lots of NAD
Bad hearts have low ATP, so NR is preferable for NAD Sirtuins require NAD NMN not considered a p...
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There's a story

Posted by Luminosity in Luminosity's Blog, 05 October 2016 - - - - - - · 1,498 views
----

Just saw a thirty-something black guy with two black eyes. He was driving a maroon Mercury Grand Marquis with chrome edging, from the old days. There was a sign in the back window of the car saying, "Trump: Make America Great Again." He wore a baseball cap and had a lot of stuff/clothes in the car. Maybe his "black eyes" were anti-glare markings. Either w...
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a way to make babies weller which also makes pregancy determinable at possibly (ummm) 24 hours

Posted by treonsverdery in treonsverdery's Blog, 05 August 2016 - - - - - - · 1,590 views
pregnancy, uterus, antibody and 2 more...

what do you think of this technology way of figuring out if you are pregnant after like, a few hours after having sex, which also causes more babies to be well. 
ok, think of the very most optimal place at the entire uterus to have implantation, people would prefer the zygote develop at that location. 
so you coat that area with aptamers, then y...
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Possibly Switching to Penibut for sleep, and Deschloroetizolam

Posted by protoject in protoject's Blog, 03 March 2016 - - - - - - · 1,975 views
phenibutdeschloroetizolam and 7 more...

Hey,
Lately I've been using Baclofen , Etizolam, and Clomethiazole on night 1 for sleep,
Then on night 2 i switch to pregabalin and pagoclone.
I used to use trazodone but went off it since starting a daily mirtazapine (perscribed). I feel like the baclofen is a really good thing in the sleep combo but I think it might affect my mood negatively the ne...
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2500 Calories and got stuff done!

Posted by YOLF in YOLF's Workouts, 12 February 2016 - - - - - - · 1,824 views
2500

Knocked out 2500 Calories today in 3 sessions, so an extra 850 today. The first 1300 were painless, tiny bit of pain on the left side behind the knee, but I think I know why, and I learned something and will modify the regimen for tomorrow to take advantage of it.. Got tons of stuff done and feel great. Motivation is back and outlook is great. I have a fe...
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Laser hair removal for anti-aging (loose) hypothesis

Posted by YOLF in YOLF's Reviews of Research Tech, 26 July 2015 - - - - - - · 2,040 views
hair removal, tria, laser

So I notice an improvement in my skin condition when I shave the body hair that stays in remit until the hair starts popping through the surface again. Shaving makes my face itch less, and the longer the hair grows, the itchier it gets. So I looked into permanent hair removal types that disable the hair follicle and found a home DIY laser called TRIA and...
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Sublingual Phenethylamine/Phenylethylamine (PEA)

Posted by YOLF in Regimen Management, 05 June 2015 - - - - - - · 2,904 views
pea, phenethylamine and 4 more...

So I've got some PEA and I'm thinking it would be better for me than some of the other things I'm using, namely adderall. Not that I don't think Adderall is without merits, just that I'd like to not sacrifice my catecholamine supersensitivity (I've previously been referring to it as hypersensitivity but reviewing the reading material on amphetamines, I'm...
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May 24th

Posted by perception is projection in What does going to any lengths look like?, 23 May 2015 - - - - - - · 2,183 views
beastmode

Lost track of the days. I am noticing that keep a journal everyday of my progress of my habits is essential. I participate in other things in life and they can consume my time, leading me off the path. Only waking up days later to realize I am off the path,

Lately getting the morning or night ritual has been hard. Mainly because of sleep patterns and som...
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Dodgy Knees

Posted by Danae in Danae's Blog, 13 May 2015 - - - - - - · 2,888 views
arthritis, cartilage, knee joints and 4 more...

Dodgy Knees Anyone on a trip to the Austrian Alps will notice a large proportion of elderly walkers striding up the mountain, and fewer striding down. Taking the cable car down the mountain after walking up is something older people with dodgy knees go in for, since walking down steep paths can be more painful.
Many people will tell you that knee pain and arthritis i...
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Storing your Goji Harvest

Posted by YOLF in YOLF on Horticulture, 07 May 2015 - - - - - - · 2,054 views
goji, goji raisins, worlfberry

So, as I said in the previous article, these things are easy to grow, indestructible, even for lackadaisical gardeners like me, and they save lots of money while providing benefits similar to those of Goji supplements. But you're going to want to keep eating them in the winder and in the early spring before your plants start producing. So here's what you'...
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Going to pick up on my reading list again

Posted by YOLF in YOLF's Book Reviews, 06 May 2015 - - - - - - · 1,966 views
reading, books, transhumanism and 3 more...

I've been avoiding my reading list for some time, cuz let's face it, I keep spending money on books and I work alot of temp jobs. But as I've been working on some life extension related projects, it became obvious that not reading books that others were following was leaving me at a communications disadvantage or had us not following the same set of instr...
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