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              Advocacy & Research for Unlimited Lifespans



Geroprotector review: Rapamycin

Posted by s123 in Sven's Science Column, 18 July 2017 - * * * * * · 6,784 views

Geroprotector review: Rapamycin Rapamycin and other mTOR inhibitors as geroprotectors

This article is solely for information purposes, not a substitute for professional medical or dietary advice. The provisos of the LongeCity user agreement apply. 

What: A drug to prevent rejection of transplanted kidneys. Also used in cancer therapy. Various related comp...


Transplanted microglia - where did they go?

Posted by Mondey in Microglia Stem Cells, 10 May 2017 - - - - - - · 2,152 views
microglia therapy

yes it has been a while since I wrote something here.  Here are two papers pusblished including the work funded by you:
Leovsky C, Fabian C, Naaldijk Y, Jäger C, Jang HJ, Böhme J, Rudolph L, Stolzing A. Biodistribution of in vitro-derived microglia applied intranasally and intravenously to mice: effects of aging. Cytotherapy. 2015 Nov;17(11):1617...


CellAge fundraiser support

Posted by caliban in Longecity Blog, in News 28 January 2017 - * * * * * · 3,862 views
fundraiser, cellage

CellAge fundraiser support UPDATE Feb.9th 2017: success!

LongeCity.Org has decided to support the current CellAgeFundraiser initiative beyond its standard support for certified ‘star-rated’ community fundraiserthrough an extension of its affiliate labprogramme. To this end we have identified a specific small ‘sub goal’ withinthe first work project...


Great results as of late

Posted by YOLF in Supplement Development, 16 November 2017 - - - - - - · 581 views
aging escape velocity

I've been using a bunch of supplements and improvised materials that just haven't been done yet and have been getting great results. Then two nights ago I add a half dose of an adjuvant to my existing regimen that can slowly remove glucosepane, or so it seems. I have it on good authority that this mechanism will be effective. The new ingredient is working...


Fall Out Boy: Immortals (LongeCity Version)

Posted by YOLF in Lyric Hijacking, 17 October 2017 - - - - - - · 800 views
fallout boy

 They say we are what we are
But we don’t have to be
I’m glad to hate you but I do it in the best way
I’ll be the watcher of the eternal flame
I’ll be the guard dog of all your forever dreams
I block the sand from the bottom half of the hourglass (Glass, glass)
I’ll try to picture me without you but I can’t
'Cause we could be immortals, immortals


Could policy revisions lead to a healthier nation?

Posted by YOLF in Opinions on Weight Loss, 26 July 2017 - - - - - - · 1,470 views
weight loss

So, I was reading this over at the FDA and it dawned on me that these safety side effects were only likely to occur in people who are aged. In young people, it would very likely not be an issue. So here's the bigger issue: 
If you take these away from young people or dissuade them from using them altogether, the young people will lose the opportunit...


Geroprotector review: Metformin

Posted by s123 in Sven's Science Column, 18 July 2017 - * * * * * · 8,266 views
metformin, geroprotector and 3 more...

Geroprotector review: Metformin Geroprotector review: Metformin
Sven Bulterijs  
This article
- is a summary - The full version can be downloaded here:
- is a 2017 (spring) update - See here for a 2011 article on metformin by the Author.
- is solely for information purposes , not a substitute for professional medical or dietary advice. The provisos of the LongeCity us...


win$100 for 'best regimen'

Posted by caliban in Longecity Blog, 09 June 2017 - - - - - - · 2,394 views

win$100 for 'best regimen' The forum structure at the heart of LongeCity works well in facilitating a free flow of communication and information exchange.
Other more structured ways of curating information have their own advantages, but their adoption appears to be more difficult.  In 2014 we closed the 'regimen' forums for brain enhancement and general supplements in favou...



Posted by caliban in caliban's Blog, 18 May 2017 - - - - - - · 2,516 views

Shalots “ Shalot ” = a made-up word for a type of person active in life extension, cryonics, artificial intelligence and related fields. Sometimes encountered on LongeCity.  The word is a constriction of ‘zealot’ and ‘shallow’ and also a reference to Tennyson’s poem ‘the Lady of Shalott’ (2x’t’) as someone who is removed from the real world, obsessed with...


How to Manufacture the Greatest Sleep of Your Life (Part 1)

Posted by gill3362 in Practical Longevity, 11 May 2017 - - - - - - · 2,481 views
sleep, rem sleep, metabolism and 7 more...

To Sleep Is to Live
Sleep is the single most underestimated ingredient impacting your health and life. Sleep is so powerful, in fact, that making even tiny improvements to this activity we spend ⅓ of our time doing can radically improve the quality of our health and our lives.
This post (part 1 of 2, so stay tuned) will introduce you to the basics of h...


Healthy smoothie life

Posted by nootrope in nootrope's Blog, 27 March 2017 - - - - - - · 1,661 views
supplements, exercise, smoothies

Life continues! 
Although in many ways I'm quite healthy (knock on wood), and looking at Facebook pictures of my classmates from high school and college, I find they often look a decade plus older than I am--in some ways too being a health nut might not be ultimately so healthy. It could be a way of postponing my life. Instead of seizing the day, I j...


More Planet Fitness Coolness

Posted by YOLF in Working Out, 18 February 2017 - - - - - - · 1,462 views

I happened to notice a Red Light Therapy room among the tanning rooms at Planet Fitness yesterday. As many will have read here on the forum, there is lots of support for for 650nm (red) light and producing collagen and not only this, but it's not tanning, it doesn't use wavelengths which are known to cause cancer. So planet fitness is apparently helping u...



Posted by Darkly Origins in Eerie Flickering (Darkly Origins), 11 January 2017 - - - - - - · 1,720 views
nootropics, newtropics and 7 more...

I am looking for a person(s) to provide me with the right acquaintances, or to otherwise help me ascertain at minimal, a month supply of a drug undergoing trials yet; the name of the drug is called "abaloparatide." Any and all referential mention, documentation, information and details about the drug will be greatly appreciated. If you are so kindly inter...


Nicotinamide Riboside - Some Notes

Posted by Anthony_Loera in Bit o' Research, 23 November 2016 - - - - - - · 2,036 views
rgnr, nice ruffles

NR - Nicotinamide Riboside NR activates SIRT2 ? (hmm not sure, I got to re-listen again)
NR one of 3 precursors to NAD
Out of the 3 precursors NR takes the least amount of ATP to make NAD, so if you have low ATP. in your system.. not lots of NAD
Bad hearts have low ATP, so NR is preferable for NAD Sirtuins require NAD NMN not considered a p...


There's a story

Posted by Luminosity in Luminosity's Blog, 05 October 2016 - - - - - - · 1,997 views

Just saw a thirty-something black guy with two black eyes. He was driving a maroon Mercury Grand Marquis with chrome edging, from the old days. There was a sign in the back window of the car saying, "Trump: Make America Great Again." He wore a baseball cap and had a lot of stuff/clothes in the car. Maybe his "black eyes" were anti-glare markings. Either w...


a way to make babies weller which also makes pregancy determinable at possibly (ummm) 24 hours

Posted by treonsverdery in treonsverdery's Blog, 05 August 2016 - - - - - - · 2,045 views
pregnancy, uterus, antibody and 2 more...

what do you think of this technology way of figuring out if you are pregnant after like, a few hours after having sex, which also causes more babies to be well. 
ok, think of the very most optimal place at the entire uterus to have implantation, people would prefer the zygote develop at that location. 
so you coat that area with aptamers, then y...


Possibly Switching to Penibut for sleep, and Deschloroetizolam

Posted by protoject in protoject's Blog, 03 March 2016 - - - - - - · 2,491 views
phenibutdeschloroetizolam and 7 more...

Lately I've been using Baclofen , Etizolam, and Clomethiazole on night 1 for sleep,
Then on night 2 i switch to pregabalin and pagoclone.
I used to use trazodone but went off it since starting a daily mirtazapine (perscribed). I feel like the baclofen is a really good thing in the sleep combo but I think it might affect my mood negatively the ne...


Laser hair removal for anti-aging (loose) hypothesis

Posted by YOLF in YOLF's Reviews of Research Tech, 26 July 2015 - - - - - - · 2,525 views
hair removal, tria, laser

So I notice an improvement in my skin condition when I shave the body hair that stays in remit until the hair starts popping through the surface again. Shaving makes my face itch less, and the longer the hair grows, the itchier it gets. So I looked into permanent hair removal types that disable the hair follicle and found a home DIY laser called TRIA and...


May 24th

Posted by perception is projection in What does going to any lengths look like?, 23 May 2015 - - - - - - · 2,675 views

Lost track of the days. I am noticing that keep a journal everyday of my progress of my habits is essential. I participate in other things in life and they can consume my time, leading me off the path. Only waking up days later to realize I am off the path,

Lately getting the morning or night ritual has been hard. Mainly because of sleep patterns and som...


Dodgy Knees

Posted by Danae in Danae's Blog, 13 May 2015 - - - - - - · 3,708 views
arthritis, cartilage, knee joints and 4 more...

Dodgy Knees Anyone on a trip to the Austrian Alps will notice a large proportion of elderly walkers striding up the mountain, and fewer striding down. Taking the cable car down the mountain after walking up is something older people with dodgy knees go in for, since walking down steep paths can be more painful.
Many people will tell you that knee pain and arthritis i...


Immortality, so much to take and so little time! Here's what you need to get the job done right.

Posted by YOLF in Regimen Management, 07 May 2015 - - - - - - · 1,223 views
supplement regimen advice, advice

Ok, so you can save a bunch of money and get exactly what you want out of your nutrition. But you want to have a longer life, and if this takes you too much time, you're not really gaining anything. So get the tools to do the job right and you can find a happy medium and an enjoyable life full of the benefits of a good supplement regimen. Here's what you'...


Storing your Goji Harvest

Posted by YOLF in YOLF on Horticulture, 07 May 2015 - - - - - - · 2,553 views
goji, goji raisins, worlfberry

So, as I said in the previous article, these things are easy to grow, indestructible, even for lackadaisical gardeners like me, and they save lots of money while providing benefits similar to those of Goji supplements. But you're going to want to keep eating them in the winder and in the early spring before your plants start producing. So here's what you'...


Going to pick up on my reading list again

Posted by YOLF in YOLF's Book Reviews, 06 May 2015 - - - - - - · 2,432 views
reading, books, transhumanism and 3 more...

I've been avoiding my reading list for some time, cuz let's face it, I keep spending money on books and I work alot of temp jobs. But as I've been working on some life extension related projects, it became obvious that not reading books that others were following was leaving me at a communications disadvantage or had us not following the same set of instr...

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