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Important Blogs

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Geroprotector review: Rapamycin

Posted by s123 in Sven's Science Column, 18 July 2017 - * * * * * · 19,359 views
rapamycin

Geroprotector review: Rapamycin Rapamycin and other mTOR inhibitors as geroprotectors

This article is solely for information purposes, not a substitute for professional medical or dietary advice. The provisos of the LongeCity user agreement apply. 





What: A drug to prevent rejection of transplanted kidneys. Also used in cancer therapy. Various related comp...
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Transplanted microglia - where did they go?

Posted by Mondey in Microglia Stem Cells, 10 May 2017 - - - - - - · 7,419 views
microglia therapy

Hi,
yes it has been a while since I wrote something here.  Here are two papers pusblished including the work funded by you:
Leovsky C, Fabian C, Naaldijk Y, Jäger C, Jang HJ, Böhme J, Rudolph L, Stolzing A. Biodistribution of in vitro-derived microglia applied intranasally and intravenously to mice: effects of aging. Cytotherapy. 2015 Nov;17(11):1617...
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CellAge fundraiser support

Posted by caliban in Longecity Blog, in News 28 January 2017 - * * * * * · 11,204 views
fundraiser, cellage

CellAge fundraiser support UPDATE Feb.9th 2017: success!







LongeCity.Org has decided to support the current CellAgeFundraiser initiative beyond its standard support for certified ‘star-rated’ community fundraiserthrough an extension of its affiliate labprogramme. To this end we have identified a specific small ‘sub goal’ withinthe first work project...
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The First Immortal: A Quantum Manifesto of Consciousness, Entanglement, and the Architecture of Eternal Mind

Posted by Darkly Origins in Eerie Flickering (Darkly Origins), 05 May 2025 - - - - - - · 538 views
immortality, primorum and 8 more...

The First Immortal: A Quantum Manifesto of Consciousness, Entanglement, and the Architecture of Eternal Mind I am releasing a book (and academic publication volume) detailing the first working instance of achieving biological immortality, and quantumly-coherent consciousness transference. Stay tuned! I will give more details soon. Tag Aubrey deGrey for me! 
The First Immortal is not a tale of fantasy—it is a declaration of scientific revelation, a codex...
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March 2025 Longevity Review

Posted by Chris Pollyanna in Chris Linnell's Longevity Review Newsletter, 25 April 2025 - - - - - - · 816 views
longevity, supplements, exosomes and 4 more...

March 2025 Longevity Review As the flowers are finally starting to bloom in my garden, we will take a look at an intriguing study which uses ultrasound to reverse cellular senescence and increase mouse lifespan; two studies on reducing lower back pain, the first using epigenetic reprogramming, while the second is a Canadian study using senolytics; and, a fascinating study where an i...
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Biological Replacement of Elements Theory

Posted by John Bumpus in John Bumpus' Blog, 10 October 2019 - - - - - - · 4,692 views
minerals, toxic, metal, heavy and 6 more...

Excerpts from my original blog post, to read the whole post and see sources, please visit the original article found here: https://www.johnbump...lements-theory.  "The “Biological Replacement of Elements Theory” (BRET) is the most essential concept behind the Integrative Mineral Balan...
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No Popes in Heaven - Book Review

Posted by caliban in caliban's Blog, 10 March 2019 - - - - - - · 4,326 views
review, malchow

No Popes in Heaven - Book Review Review for "No Popes in Heaven" (Paperback) – by Hal Malchow (Author), Susan Shallcross (Editor)  
The main plot, which attracted this reviewer’s interest, follows the political manoeuvrings around a newly discovered life extension drug Juventel. In the first chapters, the author makes a good effort to dip enough into the science that those with prio...
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Six Years of Losing Biological Age in Photometric Review (2012)

Posted by YOLF in Microsoft Photometric Age, 12 June 2018 - - - - - - · 5,884 views
life extension

The year was 2012, and I was determined to end my aging and I mean beat it back with a stick. At the start of the year, I was chronologically 31.

I was overweight, rejected, and very old looking. Food allergies and intolerances were aging me rapidly. My blood tests still came out fine most of the time, but my ancient Greek ancestors were known as immort...
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Vitamin D Supplementation vs. Catching Some Rays

Posted by Plato666 in Plato666's Blog, 19 May 2018 - * * - - - · 5,701 views
vitamin d, supplement strateg and 1 more...

Vitamin D Supplementation vs. Catching Some Rays At first blush, it may seem like those Vitamin D peddlers out there are trying to get your money by selling you stuff that you don’t really need and can get for free. Just ask a question of a multibillion dollar multinational company like NESTLE “excuse me, but who the hell buys stuff that they can get for free, like water?” and see what in the way of Pow...
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Great results as of late

Posted by YOLF in Supplement Development, 16 November 2017 - - - - - - · 7,352 views
aging escape velocity

I've been using a bunch of supplements and improvised materials that just haven't been done yet and have been getting great results. Then two nights ago I add a half dose of an adjuvant to my existing regimen that can slowly remove glucosepane, or so it seems. I have it on good authority that this mechanism will be effective. The new ingredient is working...
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Fall Out Boy: Immortals (LongeCity Version)

Posted by YOLF in Lyric Hijacking, 17 October 2017 - - - - - - · 7,122 views
fallout boy

 They say we are what we are
But we don’t have to be
I’m glad to hate you but I do it in the best way
I’ll be the watcher of the eternal flame
I’ll be the guard dog of all your forever dreams
I block the sand from the bottom half of the hourglass (Glass, glass)
I’ll try to picture me without you but I can’t
'Cause we could be immortals, immortals
It...
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Could policy revisions lead to a healthier nation?

Posted by YOLF in Opinions on Weight Loss, 26 July 2017 - - - - - - · 7,927 views
weight loss

So, I was reading this over at the FDA and it dawned on me that these safety side effects were only likely to occur in people who are aged. In young people, it would very likely not be an issue. So here's the bigger issue: 
If you take these away from young people or dissuade them from using them altogether, the young people will lose the opportunit...
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Geroprotector review: Metformin

Posted by s123 in Sven's Science Column, 18 July 2017 - * * * * * · 22,057 views
metformin, geroprotector and 3 more...

Geroprotector review: Metformin Geroprotector review: Metformin
Sven Bulterijs  
This article
- is a summary - The full version can be downloaded here:
- is a 2017 (spring) update - See here for a 2011 article on metformin by the Author.
- is solely for information purposes , not a substitute for professional medical or dietary advice. The provisos of the LongeCity us...
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win$100 for 'best regimen'

Posted by caliban in Longecity Blog, 09 June 2017 - - - - - - · 10,902 views
competition

win$100 for 'best regimen' The forum structure at the heart of LongeCity works well in facilitating a free flow of communication and information exchange.
Other more structured ways of curating information have their own advantages, but their adoption appears to be more difficult.  In 2014 we closed the 'regimen' forums for brain enhancement and general supplements in favou...
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How to Manufacture the Greatest Sleep of Your Life (Part 1)

Posted by gill3362 in Practical Longevity, 11 May 2017 - * * * * * · 9,559 views
sleep, rem sleep, metabolism and 7 more...

To Sleep Is to Live
Sleep is the single most underestimated ingredient impacting your health and life. Sleep is so powerful, in fact, that making even tiny improvements to this activity we spend ⅓ of our time doing can radically improve the quality of our health and our lives.
This post (part 1 of 2, so stay tuned) will introduce you to the basics of h...
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Healthy smoothie life

Posted by nootrope in nootrope's Blog, 27 March 2017 - - - - - - · 5,429 views
supplements, exercise, smoothies

Life continues! 
Although in many ways I'm quite healthy (knock on wood), and looking at Facebook pictures of my classmates from high school and college, I find they often look a decade plus older than I am--in some ways too being a health nut might not be ultimately so healthy. It could be a way of postponing my life. Instead of seizing the day, I j...
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More Planet Fitness Coolness

Posted by YOLF in Working Out, 18 February 2017 - - - - - - · 4,881 views
coolness

I happened to notice a Red Light Therapy room among the tanning rooms at Planet Fitness yesterday. As many will have read here on the forum, there is lots of support for for 650nm (red) light and producing collagen and not only this, but it's not tanning, it doesn't use wavelengths which are known to cause cancer. So planet fitness is apparently helping u...
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Nicotinamide Riboside - Some Notes

Posted by Anthony_Loera in Bit o' Research, 23 November 2016 - - - - - - · 5,412 views
rgnr, nice ruffles

NR - Nicotinamide Riboside NR activates SIRT2 ? (hmm not sure, I got to re-listen again)
NR one of 3 precursors to NAD
Out of the 3 precursors NR takes the least amount of ATP to make NAD, so if you have low ATP. in your system.. not lots of NAD
Bad hearts have low ATP, so NR is preferable for NAD Sirtuins require NAD NMN not considered a p...
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There's a story

Posted by Luminosity in Luminosity's Blog, 05 October 2016 - - - - - - · 6,447 views
----

Just saw a thirty-something black guy with two black eyes. He was driving a maroon Mercury Grand Marquis with chrome edging, from the old days. There was a sign in the back window of the car saying, "Trump: Make America Great Again." He wore a baseball cap and had a lot of stuff/clothes in the car. Maybe his "black eyes" were anti-glare markings. Either w...
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a way to make babies weller which also makes pregancy determinable at possibly (ummm) 24 hours

Posted by treonsverdery in treonsverdery's Blog, 05 August 2016 - - - - - - · 5,406 views
pregnancy, uterus, antibody and 2 more...

what do you think of this technology way of figuring out if you are pregnant after like, a few hours after having sex, which also causes more babies to be well. 
ok, think of the very most optimal place at the entire uterus to have implantation, people would prefer the zygote develop at that location. 
so you coat that area with aptamers, then y...
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Possibly Switching to Penibut for sleep, and Deschloroetizolam

Posted by protoject in protoject's Blog, 03 March 2016 - - - - - - · 6,118 views
phenibutdeschloroetizolam and 7 more...

Hey,
Lately I've been using Baclofen , Etizolam, and Clomethiazole on night 1 for sleep,
Then on night 2 i switch to pregabalin and pagoclone.
I used to use trazodone but went off it since starting a daily mirtazapine (perscribed). I feel like the baclofen is a really good thing in the sleep combo but I think it might affect my mood negatively the ne...
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Laser hair removal for anti-aging (loose) hypothesis

Posted by YOLF in YOLF's Reviews of Research Tech, 26 July 2015 - - - - - - · 6,097 views
hair removal, tria, laser

So I notice an improvement in my skin condition when I shave the body hair that stays in remit until the hair starts popping through the surface again. Shaving makes my face itch less, and the longer the hair grows, the itchier it gets. So I looked into permanent hair removal types that disable the hair follicle and found a home DIY laser called TRIA and...
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May 24th

Posted by perception is projection in What does going to any lengths look like?, 23 May 2015 - - - - - - · 6,169 views
beastmode

Lost track of the days. I am noticing that keep a journal everyday of my progress of my habits is essential. I participate in other things in life and they can consume my time, leading me off the path. Only waking up days later to realize I am off the path,

Lately getting the morning or night ritual has been hard. Mainly because of sleep patterns and som...
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