LONGECITY

My October Longevity Review is now available:

https://www.longecit...ngevity-review/

I recommend Chris's newsletter. It is quite comprehensive and well-organized.

A WONDERFUL GIFT TO THIS FORUM.  THANK YOU VERY MUCH!!!!

My November Review of all things longevity has just been published. November turned out to be a bumper month - take a look!

https://www.longecit...ngevity-review/

My last monthly review of 2020 is now available:

https://www.longecit...ngevity-review/

Happy New Year! 

Hi Sedentary,

 

I get my spermidine from wheat germ! Wheat germ has the highest concentration of spermidine in food at up to 243 mg/kg according to Wikipedia. I add a couple of heaped teaspoons into my berry & nut breakfast, which tastes well together. Wheat germ is also incredibly cheap    

 

There is an Austrian supplement company which sells it as well founded by the main researchers into spermidine: https://shop.thelongevitylabs.com/en

 

Chris

IIRC fresh cheddar has very little to no spermidine, 1 year aged cheddar has 199mg/kg.   2 year 3 year 4 year old cheddar hasn't been looked into, afaik.   But judging by what happens from fresh cheddar to 1 year old cheddar that suggests cheddar spermidine content might increase significantly each year.    That's why I try to eat 2 to 4 year old aged cheddar.

Happy new year.

Chris

I would like to make a modest monthly financial contribution to your work, such as to your patreon account.  Thanks for your informative newsletter!

Chris

 

I would like to make a modest monthly financial contribution to your work, such as to your patreon account.  Thanks for your informative newsletter!

Krell

That is so unexpectedly amazing! I was completely blown away by your kind offer - I get enough of a thrill when somebody just thanks me, so to read what you wrote... wow!

I had been thinking about patreon, but felt a bit shy about asking for money. However, you've given me the kick I needed so I have quickly set up an account.

https://www.patreon....user?u=48142979

Thank you so much!

Chris

My end of year review of 2020 has now been posted:

https://www.longecit...year-in-review/

Delayed due to marking, my January Longevity Review is now available:

https://www.longecit...ngevity-review/

My even more delayed February Longevity Review is now available...

https://www.longecit...ngevity-review/

My March Longevity Review is now available:

https://www.longecit...ngevity-review/

My April Longevity Review with some exciting news about a forthcoming Rapamycin crowdfunding campaign is now available:

https://www.longecit...ngevity-review/

My May Longevity Review is now available:

https://www.longecit...ngevity-review/

Hi Chris,

 

Analyses of the ingredients and finished baked goods showed that spermidine is heat-sensitive, contrary to an earlier published statement [16]. In the present case, the quotient is about 3.4 between spermidine used (roll A: 149.4 mg/kg; roll B: 98.8 mg/kg) and the concentration in the finished baked goods (roll A: 47.1 mg/kg; roll B: 26.5 mg/kg).

 

https://link.springe...20-01758-y#Sec6

Based on this quote, wheat germ should be eaten raw? I have a jar of wheat germ and its label says "toasted wheatgerm" so that means about two thirds of its spermidine is gone, am I understanding this correctly?

Many thanks for your monthly letter.

My June Longevity Review is now available:

https://www.longecit...ngevity-review/

And to answer the post above, I eat my wheat germ raw to maximize the spermidine content.

My latest Longevity Review Newsletter is now available:

https://www.longecit...ngevity-review/

My August Longevity Review is finally available:

https://www.longecit...ngevity-review/

My September Longevity Review is now posted:

https://www.longecit...ngevity-review/

The October 2021 Longevity Review is now available:

https://www.longecit...ngevity-review/

My November Longevity Review is now available. 

https://www.longecit...ngevity-review/

The final Longevity Review of 2021 is now available! 

https://www.longecit...ngevity-review/

Thank you for doing this.  I note that you take Resveratrol and Pterostilbene. I tend to prefer Pterostilbene because Resveratrol is a cox-1 inhibitor and I don't like the idea of downregulating things like Melatonin, Adenosine and Cortisol (on an aggregate basis and particularly Melatonin).  Do you have a view as to the comparative merits of Resveratrol and Pterostilbene?

Hi John,

Thanks for your question!

The reason I take them both is simply the fact that I could get a supplement from Swanson which has 250mg Resveratrol combined with 50mg Pterostilbene (though I have been out for the last few months). I have always thought of them as being very similar, with Pterostilbene having a higher bioavailability. Truth be told, I don't remember having seen any study where their use was combined, so my usage of them is a gamble, but I have seen enough studies showing benefits in them individually that I don't see it as a high risk gamble.

I haven't done a comparative analysis of their respective benefits/detriments.

I was also unaware of Resveratrol's potential downregulation of Melatonin etc - would you have a link to that?

At the end of the day, despite plenty of research in the past couple of decades, we still don't know the full risk/reward ratio for most supplements, so it is a matter of your own risk tolerance to take them or not.

Chris

Resveratrol inhibits Cox-1

https://pubmed.ncbi....h.gov/15020596/

Cox-1 is needed to create Melatonin, Cortisol and Adenosine.

Pterostilbene inhibits Cox-2 

That is something I don't mind.

There are still gaps in knowledge.

Hi Old Grandpa,

I don't completely avoid red meat, I've just reduced my consumption and increased my consumption of plant proteins such as legumes & mushrooms and seafood like salmon and sardines. It's more a case of red meat being crowded out by more healthy foods. And again, I still eat red meat most weeks - I love a good steak! 

The reason is a raft of epidemiological and observational studies showing health benefits and a desire to reduce my production of TMAO.

In the research I do, I come across study after study showing potential benefits from molecules found in plants and seafood, whereas I rarely if ever see such positive studies on red meat. 

Chris

PS - at first glance Jaminet's diet looks OK, though I would take issue at the avoidance of legumes (and for the most part whole grains, unless you have a gluten intolerance). But, I am weary of recommending any diet (apart from the Mediterranean one) as diets are not one size fits all, and each of us responds differently depending on our genetics, microbiome etc

My 2021 Longevity End of Year Review is now available (finally!),

To save myself some time and to hopefully make it more relevant, I am only including human studies.

https://www.longecit...of-year-review/

My 2021 Longevity End of Year Review is now available (finally!),

 

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