215 replies to this topic

[Strangelove]

 

 

I was looking the Nixon movie again yesterday and propranolol could possibly give Nixon a solution to his sweating issue.  

 

 

Maybe, but it probably wouldn't have done anything to hide the lies coming out through his teeth.

 

 

yea difficult to hide, but with a xanax - propranolol combo could still look cool.

 

The whole discussion with the correlation of amygdala and fear its pretty interesting. We should concentrate both in the neurochemistry of fear, but also in experiences of the many anxyolitics mentioned on line for something effective in targeting negative emotions without clouding the thinking process.

[eon]

Not sure if the compounds discussed here have potential:

 

Intra-amygdala kinase inhibitors disrupt retention of a learned avoidance response in rats 

 

http://www.sciencedi...304394094900957

 

Inhibitory avoidance learning alters the amygdala calcium/calmodulin-dependent protein kinase II activity in rats

 

http://www.sciencedi...00689939601298X

 

But below is the most interesting find, of all things an antibiotic called anisomycin:

 

Anisomycin is also mentioned as a potential psychiatric drug, as it may inhibit the consolidation of new context-specific long-term memories.".,^[3] as well as long time consolidated memories rendered labile through reactivation.^[4]

Injection of anisomycin into the hippocampus has been proposed for selective removal of memories.^[5]

^{http://en.wikipedia....wiki/Anisomycin}

 

Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval

http://www.nature.co...l/406722a0.html

 

'New' memories are initially labile and sensitive to disruption before being consolidated into stable long-term memories^{1, 2, 3, 4, 5}. Much evidence indicates that this consolidation involves the synthesis of new proteins in neurons^{6, 7, 8, 9}. The lateral and basal nuclei of the amygdala (LBA) are believed to be a site of memory storage in fear learning¹⁰. Infusion of the protein synthesis inhibitor anisomycin into the LBA shortly after training prevents consolidation of fear memories¹¹. Here we show that consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin shortly after memory reactivation produces amnesia on later tests, regardless of whether reactivation was performed 1 or 14 days after conditioning. The same treatment with anisomycin, in the absence of memory reactivation, left memory intact. Consistent with a time-limited role for protein synthesis production in consolidation, delay of the infusion until six hours after memory reactivation produced no amnesia. Our data show that consolidated fear memories, when reactivated, return to a labile state that requires de novo protein synthesis for reconsolidation. These findings are not predicted by traditional theories of memory consolidation.

 

Here, we show that infusion of the protein synthesis inhibitor anisomycin into the basolateral amygdala disrupts consolidation of both trace and delay fear  ...

 

https://books.google...ibitors&f=false

 

 

Anisomycin, a protein synthesis inhibitor, disrupts traumatic memory consolidation and attenuates posttraumatic stress response in rats.

 

http://www.ncbi.nlm....pubmed/16735032

 

 

Freeing bad memories

 

http://www.apa.org/m...0/memories.aspx

 

"Because anisomycin is toxic to humans, this particular procedure can’t be used to help people overcome phobias or PTSD. However, some researchers have used the blood-pressure medication propranolol to interrupt the memory reconsolidation process in human participants, LeDoux said."

 

I wonder who or what anisomycin is prescribed for?

Edited by eon, 27 May 2015 - 11:18 AM.

[Strangelove]

This would be of interest, I think I already mentioned it before. I have tried D-cycloserine only couple times before and gave me a dissociative feeling, I have not tested long enough to see results, but I may buy it again in the future. 

 

http://www.dana.org/...xtinguish_Fear/

 

https://newmind.com/d-cycloserine.html

[Heisenburger]

This is getting ridiculous. A hundred years from now, we’re going to be going to our psychiatrists like going to Supercuts. After waiting three hours in the reception room, hopelessly rifling through a mountain of magazines looking for ANYTHING of even remote interest to men other than a three-year-old back issue of GQ, we’ll be seated in a comfortable anti-gravity recliner and a bubbly 20-year-old technician named Tiffany will put a helmet on our heads, set up the drip infusion, and say “now what can we do for you today?”

 

“Well, I have an upcoming final in n-dimensional quantum superfluid theory, so if you could bump up my hippocampus about five percent, that would be great. But not too much—when my hippo gets too big it makes my forehead itch. But I got carjacked by Jihadist terrorists from the Nation of Dearborn last week, so if you could shave a bit off the amygdala, that would be nice. Oh, and last week my neighbor’s dog shit on my lawn again, so I phased it. I know I really should have set the phaser to ‘stun,’ but I was just so hopping mad I vaporized the little barking bastard instead. That seems just a bit sociopathic, don’t you think? Maybe we could tweak the prefrontal cortex a little? Not too much, though—I’m still going for that promotion at work and being a little bit of an asshole will come in handy. Also, I had this weird sex dream the other night involving my grandmother. Could you check the locus coeruleus for me while you’re in there…?”

[Strangelove]

It depends what we think might be possible, I would really appreciate to be in a flow state all the time, motivated with no irrational fears and high energy.

 

Brain training with machines and the addition of brain supplements I imagine to be the "equivelant" of a well trained, well fed body with extra strength and endurance. Although going after every perceived "flaw" try to become "better" in every detail can get into a kind of obsession that fortunately is not common in Longecity.

 

 

 

 

Edited by Strangelove, 27 May 2015 - 09:56 PM.

[Heisenburger]

I would really appreciate to be in a flow state all the time, motivated with no irrational fears and high energy.

 

I’d say I’m almost there with the NSI-189 and the tianeptine. My latest project is trying to figure out a way to use both the sodium salt and the sulfate forms of the latter compound in conjunction. Seems to be working quite nicely, but it’s probably going to take me several more weeks to work out the exact dosages and timing. My thinking is this: try to find the smallest possible dose of the sodium salt that confers a just barely perceptible psychoactive effect, and take it at the same time as the sulfate, such that the sulfate prolongs the effect of the sodium salt and lets you down gently after a few hours or so. So far this seems to be working very, very well, and it doesn’t appear to be turning me into a tianeptine junkie.

[eon]

can't wait for that day to come, LOLZ!!!

 

This is getting ridiculous. A hundred years from now, we’re going to be going to our psychiatrists like going to Supercuts. After waiting three hours in the reception room, hopelessly rifling through a mountain of magazines looking for ANYTHING of even remote interest to men other than a three-year-old back issue of GQ, we’ll be seated in a comfortable anti-gravity recliner and a bubbly 20-year-old technician named Tiffany will put a helmet on our heads, set up the drip infusion, and say “now what can we do for you today?”

 

“Well, I have an upcoming final in n-dimensional quantum superfluid theory, so if you could bump up my hippocampus about five percent, that would be great. But not too much—when my hippo gets too big it makes my forehead itch. But I got carjacked by Jihadist terrorists from the Nation of Dearborn last week, so if you could shave a bit off the amygdala, that would be nice. Oh, and last week my neighbor’s dog shit on my lawn again, so I phased it. I know I really should have set the phaser to ‘stun,’ but I was just so hopping mad I vaporized the little barking bastard instead. That seems just a bit sociopathic, don’t you think? Maybe we could tweak the prefrontal cortex a little? Not too much, though—I’m still going for that promotion at work and being a little bit of an asshole will come in handy. Also, I had this weird sex dream the other night involving my grandmother. Could you check the locus coeruleus for me while you’re in there…?”

 

[Heisenburger]

 

can't wait for that day to come, LOLZ!!!

 

Hopefully you won't be too old to admire Tiffany's rack.

[eon]

I don't get what the reason is for using 2 different forms of tianeptine. What is it you're trying to achieve here? I think the "standard" tianeptine tablet is 12.5 mg, so I'm curious what your dosages are? I had been curious about tianeptine for a while now but never tried it.

 

I must admit that for whatever reason my vyvanse doesn't seem to be on the same level as Bromantane and Phenylpiracetam in that I truly notice the latter 2 to be actually better. High energy, anxiolytic and their profiles mentioned that I'd be able to handle cold weather much better and its' true. Also the driving was smooth actually. Not sure if my 20mg dose of Vyvanse is too low considering in comparison that Bromantane comes in 50 mg pills and Phenilpiracetam comes in 100mg doses. There was never a crash on either both but there is with Vyvanse. Vyvanse isn't marketed as anxiolytic either. I can tolerate Vyvanse. From what I've read that low doses may idiosyncratically have the opposite effects of what it's true potential hold so it's possible my dose is really low and should be upped. Maybe the norepinephrine action of Vyvanse (or any amphetamine) isn't really needed considering Bromtane and Phenilpiracetam, to my knowledge are mostly dopaminergics and none of the NE actions. Even Kava was noticeably more euphoric than Vyvanse (not that I ever noticed any euphoria with Vyvanse).

 

I'll up my dose of Vyvanse and see what's up. Seems as if the nootropics available without prescription are actually better, in a lot of ways. Strange.

 

 

I would really appreciate to be in a flow state all the time, motivated with no irrational fears and high energy.

 

I’d say I’m almost there with the NSI-189 and the tianeptine. My latest project is trying to figure out a way to use both the sodium salt and the sulfate forms of the latter compound in conjunction. Seems to be working quite nicely, but it’s probably going to take me several more weeks to work out the exact dosages and timing. My thinking is this: try to find the smallest possible dose of the sodium salt that confers a just barely perceptible psychoactive effect, and take it at the same time as the sulfate, such that the sulfate prolongs the effect of the sodium salt and lets you down gently after a few hours or so. So far this seems to be working very, very well, and it doesn’t appear to be turning me into a tianeptine junkie.

 

 

Edited by eon, 28 May 2015 - 06:20 AM.

[Strangelove]

 

I would really appreciate to be in a flow state all the time, motivated with no irrational fears and high energy.

 

I’d say I’m almost there with the NSI-189 and the tianeptine. My latest project is trying to figure out a way to use both the sodium salt and the sulfate forms of the latter compound in conjunction. Seems to be working quite nicely, but it’s probably going to take me several more weeks to work out the exact dosages and timing. My thinking is this: try to find the smallest possible dose of the sodium salt that confers a just barely perceptible psychoactive effect, and take it at the same time as the sulfate, such that the sulfate prolongs the effect of the sodium salt and lets you down gently after a few hours or so. So far this seems to be working very, very well, and it doesn’t appear to be turning me into a tianeptine junkie.

 

 

Where do you buy them from? I was ready to place an order for tianeptine.

[Heisenburger]

Powder City and Ceretropic have the best prices, with PC being cheaper by a fair margin. Both are of course reputable. If you have extra empty tubs lying around, go with the PC stuff because they save costs by shipping in baggies. However, only Ceretropic carries the sulfate form; it’s a proprietary (sort of) invention of theirs. They recommend 40 mgs. of the sulfate once or twice a day. The sulfate form provides a sustained release of the drug over several hours, whereas the sodium salt is absorbed more or less instantly. You will feel the effects of the sodium salt about 15 minutes after you ingest it, and the effects will last about two hours. That’s my rationale for using both; the sodium salt kick-starts it, and the sulfate form keeps it going throughout the day. I’m using 40 mgs. of the sulfate, about 75 mgs. of the sodium, and 40 mgs NSI-189 all at once, usually once per day, but sometimes twice. If you have any trouble getting it, just let me know and I’ll send you some. I have tons of it, because the vendors are always running out, so I buy large quantities from several vendors at once so I always have it on hand. Bear in mind that these are very supratherapeutic doses; the therapeutic dose is about one-fifth of what I’m taking. I want to eventually settle on 40/40/40 once or twice daily. This is working bloody wonders for me. Before I started this regimen, all I wanted to do after work was take a shower, eat, and crawl into a hole and die. Now all I want to do is come home, shower, eat, and tackle a molecular genetics text until one o’clock in the morning when I have to force myself to go to bed. This can’t be due to anything else I’m taking, because the only other psychoactive substance I use is coffee. Not counting the NSI-189/tianeptine regimen, the rest of my stack is quite simple and consists of the following:

 

4.8 grams piracetam

One drop 1% methylene blue solution

4 milligrams C60 (one teaspoon 0.08% homemade solution)

25 mgs. coluracetam

5 mgs. PRL-8-53

25 mgs. fasoracetam

2 caps LEF Mix

325 mgs. aspirin

75 milligrams aminoguanidine

20 mgs. PQQ

 

[Heisenburger]

Oh, and Nyles sells the stuff on ebay, but his prices are a bit steep.

[eon]

Heisenburger, I think the other compounds you're taking may have something to do with your well being. My Piracetam use alone before was enough to feel great. Is your aspirin intake to fight inflammation?

[Strangelove]

Powder City and Ceretropic have the best prices, with PC being cheaper by a fair margin. Both are of course reputable. If you have extra empty tubs lying around, go with the PC stuff because they save costs by shipping in baggies. However, only Ceretropic carries the sulfate form; it’s a proprietary (sort of) invention of theirs. They recommend 40 mgs. of the sulfate once or twice a day. The sulfate form provides a sustained release of the drug over several hours, whereas the sodium salt is absorbed more or less instantly. You will feel the effects of the sodium salt about 15 minutes after you ingest it, and the effects will last about two hours. That’s my rationale for using both; the sodium salt kick-starts it, and the sulfate form keeps it going throughout the day. I’m using 40 mgs. of the sulfate, about 75 mgs. of the sodium, and 40 mgs NSI-189 all at once, usually once per day, but sometimes twice. If you have any trouble getting it, just let me know and I’ll send you some. I have tons of it, because the vendors are always running out, so I buy large quantities from several vendors at once so I always have it on hand. Bear in mind that these are very supratherapeutic doses; the therapeutic dose is about one-fifth of what I’m taking. I want to eventually settle on 40/40/40 once or twice daily. This is working bloody wonders for me. Before I started this regimen, all I wanted to do after work was take a shower, eat, and crawl into a hole and die. Now all I want to do is come home, shower, eat, and tackle a molecular genetics text until one o’clock in the morning when I have to force myself to go to bed. This can’t be due to anything else I’m taking, because the only other psychoactive substance I use is coffee. Not counting the NSI-189/tianeptine regimen, the rest of my stack is quite simple and consists of the following:

 

4.8 grams piracetam

One drop 1% methylene blue solution

4 milligrams C60 (one teaspoon 0.08% homemade solution)

25 mgs. coluracetam

5 mgs. PRL-8-53

25 mgs. fasoracetam

2 caps LEF Mix

325 mgs. aspirin

75 milligrams aminoguanidine

20 mgs. PQQ

 

Thank you for the information and the offer for tianeptine, I was going to buy a few things from Ceretropic and I ll add tianeptine sulfate also. Do you think that tianeptine sodium is a "necessary" addition? It seems to me that a sustained release tianeptine might be enough?

 

Although the title of this forum is about fear, I think something that could eliminate all the negative emotions from the amygdala could be a good antidepressant. The pilot that crushed the plane, according to the descriptions seemed like someone with a very overactive right amygdala, very high neuroticism as would be described in the big five personality traits. Something that would be able to turn down the volume to that structure, would be very effective for his kind of depression.

 

I do not remember the details (as I was reading the text couple years ago) but there are structures in the left prefrontal that regulate the activity of the right amygdala, that could turn down the volume of negative emotions with conscious will that would not involve rationalizations to achieve. Its quite possible to be neurofeedback sessions helping with this, but I have not looked at it.

[Heisenburger]

Is your aspirin intake to fight inflammation?

 

Family history of MI and CVA. Both of my parents and my paternal grandfather only made it to 77. I’d hate to think that I’m only going to be spinning around on this Little Blue Rock for another 24 years. (Although technically speaking I’m not spinning, as I don’t live at the Geographical North Pole. I tried to squat there once, but some fat assed clown in a red suit chased me off with a 12-gauge.) Now that I’m at the age where I’ve finally figured out all the bonehead mistakes that I’ve made in my life and how to prevent them from happening again, I want to get some shit done.

[Heisenburger]

Although the title of this forum is about fear, I think something that could eliminate all the negative emotions from the amygdala could be a good antidepressant. The pilot that crushed the plane, according to the descriptions seemed like someone with a very overactive right amygdala, very high neuroticism as would be described in the big five personality traits. Something that would be able to turn down the volume to that structure, would be very effective for his kind of depression.

 

I do not remember the details (as I was reading the text couple years ago) but there are structures in the left prefrontal that regulate the activity of the right amygdala, that could turn down the volume of negative emotions with conscious will that would not involve rationalizations to achieve. Its quite possible to be neurofeedback sessions helping with this, but I have not looked at it.

 

 

 

Most people seem to get off on the warm fuzzy little buzz that the sodium salt provides. The sulfate doesn’t give you that. I’ve even heard a few anecdotes about people carrying it around with them all day so they could dose every few hours to keep it going, like people did in the glory days of GHB. Fortunately, I’ve never felt the compulsion to do that. I’d say just try it both ways, with and without the sodium salt, and see which one suits you better. I just like the little extra pep that it gives me in the morning.

 

I’ll look into the amygdala thing. One of my bucket list goals used to be to read the entire Norton Series on Interpersonal Neurobiology, but I gave it up when they started publishing volumes faster than I could read them or afford to buy them. I still have about 15 volumes on a shelf right behind me. I used to know a lot about the amygdala and its role in early fear conditioning and subsequent effects on adolescent and adult personality development, but the details are escaping me now. You really shouldn’t put too much stock in the MBTI. It’s not taken seriously by academicians. You’d be better off taking a freshman course in personality theory and learning more about established theories. If you have your basic statistics down and can work with matrices, you should take a shot at tackling factor analysis. I still have the first edition copy of A First Course in Factor Analysis that Andrew Comrey inscribed and gave to my father for Christmas in 1976. Still the best introductory text in existence.

 

Edited by Heisenburger, 29 May 2015 - 05:53 PM.

[eon]

Heisenburger, I hope you're not falling into the addictive potential of Tianeptine. There was talk of it on reddit that it's more addictive and or just as addictive as any of the opioid drugs. The way you're talking about it and using it at such doses sounds to me like an addiction. I could be wrong about your situation, or you could be in denial. Tianeptine does have action on the opioid receptor which makes it a mild analgesic. But back to amygdala...

 

Here's the conversation regarding tianeptine: http://www.reddit.co..._tianeptine_as/

Edited by eon, 30 May 2015 - 10:37 AM.

[Strangelove]

 

Although the title of this forum is about fear, I think something that could eliminate all the negative emotions from the amygdala could be a good antidepressant. The pilot that crushed the plane, according to the descriptions seemed like someone with a very overactive right amygdala, very high neuroticism as would be described in the big five personality traits. Something that would be able to turn down the volume to that structure, would be very effective for his kind of depression.

 

I do not remember the details (as I was reading the text couple years ago) but there are structures in the left prefrontal that regulate the activity of the right amygdala, that could turn down the volume of negative emotions with conscious will that would not involve rationalizations to achieve. Its quite possible to be neurofeedback sessions helping with this, but I have not looked at it.

 

 

 

Most people seem to get off on the warm fuzzy little buzz that the sodium salt provides. The sulfate doesn’t give you that. I’ve even heard a few anecdotes about people carrying it around with them all day so they could dose every few hours to keep it going, like people did in the glory days of GHB. Fortunately, I’ve never felt the compulsion to do that. I’d say just try it both ways, with and without the sodium salt, and see which one suits you better. I just like the little extra pep that it gives me in the morning.

 

I’ll look into the amygdala thing. One of my bucket list goals used to be to read the entire Norton Series on Interpersonal Neurobiology, but I gave it up when they started publishing volumes faster than I could read them or afford to buy them. I still have about 15 volumes on a shelf right behind me. I used to know a lot about the amygdala and its role in early fear conditioning and subsequent effects on adolescent and adult personality development, but the details are escaping me now. You really shouldn’t put too much stock in the MBTI. It’s not taken seriously by academicians. You’d be better off taking a freshman course in personality theory and learning more about established theories. If you have your basic statistics down and can work with matrices, you should take a shot at tackling factor analysis. I still have the first edition copy of A First Course in Factor Analysis that Andrew Comrey inscribed and gave to my father for Christmas in 1976. Still the best introductory text in existence.

 

 

No I was speaking for neuroticism from the big five that is academicaly favored, although in my experience far less useful in every day life from MBTI. Its highly related to the function of the right amygdala, It would be helpful if somehow we could turn the volume of the right amygdala down!

 - from wikipedia Neuroticism[edit]

Neuroticism is the tendency to experience negative emotions, such as anger, anxiety, or depression.^[44] It is sometimes called emotional instability, or is reversed and referred to as emotional stability. According to Eysenck's (1967) theory of personality, neuroticism is interlinked with low tolerance for stress or aversive stimuli.^[45] Those who score high in neuroticism are emotionally reactive and vulnerable to stress. They are more likely to interpret ordinary situations as threatening, and minor frustrations as hopelessly difficult. Their negative emotional reactions tend to persist for unusually long periods of time, which means they are often in a bad mood. For instance, neuroticism is connected to a pessimistic approach toward work, confidence that work impedes personal relationships, and apparent anxiety linked with work.^[46] Furthermore, those who score high on neuroticism may display more skin conductance reactivity than those who score low on neuroticism.^[45][47] These problems in emotional regulation can diminish the ability of a person scoring high on neuroticism to think clearly, make decisions, and cope effectively with stress.^{[citation needed]} Lacking contentment in one's life achievements can correlate with high neuroticism scores and increase one's likelihood of falling into clinical depression.^[48] Moreover, individuals high on neuroticism tend to experience more negative life events,^[44][49] but neuroticism also changes in response to positive and negative life experiences.^[44][49]

At the other end of the scale, individuals who score low in neuroticism are less easily upset and are less emotionally reactive. They tend to be calm, emotionally stable, and free from persistent negative feelings. Freedom from negative feelings does not mean that low scorers experience a lot of positive feelings.^[50]

Neuroticism is similar but not identical to being neurotic in the Freudian sense (i.e. neurosis.) Some psychologists prefer to call neuroticism by the term emotional stability to differentiate it from the term neurotic in a career test.

[Heisenburger]

Heisenburger, I hope you're not falling into the addictive potential of Tianeptine. There was talk of it on reddit that it's more addictive and or just as addictive as any of the opioid drugs. The way you're talking about it and using it at such doses sounds to me like an addiction.

 

I thought of that, but I don’t think that’s the case. But I’m keeping close tabs on it. The fact that I very often come home at night and simply forget to take my evening NSI-189/tianeptine combo strongly suggests that it’s not an issue. Also, a remarkable resistance to opiate abuse runs on both sides of my family. Our Kryptonite is alcohol and benzos, and only on my mother’s side. Just to be on the safe side though, I’ve already started with the strict 40/40/40 plan I outlined previously. At the first sign that I’m ever Jonesing for a fix, it’s either going straight down the toilet, or I’m going to mail it all to Strangelove. Strangely enough, the most powerfully addictive substance I’ve ever encountered (even more so than nicotine) is coffee. Take away my java and I’ll be miserable for several weeks.

[eon]

I totally missed that you mentioned it, I think I remembered but didn't look into d-cycloserine close enough until now to realize that its structure is somewhat similar to the antibiotic I mentioned. I can't recall what it was that made me not like its profile but it may have something to do with toxicity? I'd have to look more into it. Newmind has it on backorder or it could have been discontinued...

 

 

This would be of interest, I think I already mentioned it before. I have tried D-cycloserine only couple times before and gave me a dissociative feeling, I have not tested long enough to see results, but I may buy it again in the future. 

 

http://www.dana.org/...xtinguish_Fear/

 

https://newmind.com/d-cycloserine.html

 

[eon]

If you have tried the nootropics that have the profile as an anxiolytic and stimulant, I think it works well for what you described. Have you tried Bromantane or Phenylpiracetam?

 

What this thread is about and what I'm looking for is to completely eliminate the feeling of fear and or any knowledge of it. I want it GONE. If a tiger were to attack me so be it, at least I won't die in fear. LOL I'd pet it as it attacks me. Everyone has to go someday...

 

 

 

 

Although the title of this forum is about fear, I think something that could eliminate all the negative emotions from the amygdala could be a good antidepressant. The pilot that crushed the plane, according to the descriptions seemed like someone with a very overactive right amygdala, very high neuroticism as would be described in the big five personality traits. Something that would be able to turn down the volume to that structure, would be very effective for his kind of depression.

 

I do not remember the details (as I was reading the text couple years ago) but there are structures in the left prefrontal that regulate the activity of the right amygdala, that could turn down the volume of negative emotions with conscious will that would not involve rationalizations to achieve. Its quite possible to be neurofeedback sessions helping with this, but I have not looked at it.

 

 

 

Most people seem to get off on the warm fuzzy little buzz that the sodium salt provides. The sulfate doesn’t give you that. I’ve even heard a few anecdotes about people carrying it around with them all day so they could dose every few hours to keep it going, like people did in the glory days of GHB. Fortunately, I’ve never felt the compulsion to do that. I’d say just try it both ways, with and without the sodium salt, and see which one suits you better. I just like the little extra pep that it gives me in the morning.

 

I’ll look into the amygdala thing. One of my bucket list goals used to be to read the entire Norton Series on Interpersonal Neurobiology, but I gave it up when they started publishing volumes faster than I could read them or afford to buy them. I still have about 15 volumes on a shelf right behind me. I used to know a lot about the amygdala and its role in early fear conditioning and subsequent effects on adolescent and adult personality development, but the details are escaping me now. You really shouldn’t put too much stock in the MBTI. It’s not taken seriously by academicians. You’d be better off taking a freshman course in personality theory and learning more about established theories. If you have your basic statistics down and can work with matrices, you should take a shot at tackling factor analysis. I still have the first edition copy of A First Course in Factor Analysis that Andrew Comrey inscribed and gave to my father for Christmas in 1976. Still the best introductory text in existence.

 

 

No I was speaking for neuroticism from the big five that is academicaly favored, although in my experience far less useful in every day life from MBTI. Its highly related to the function of the right amygdala, It would be helpful if somehow we could turn the volume of the right amygdala down!

 - from wikipedia Neuroticism[edit]

Neuroticism is the tendency to experience negative emotions, such as anger, anxiety, or depression.^[44] It is sometimes called emotional instability, or is reversed and referred to as emotional stability. According to Eysenck's (1967) theory of personality, neuroticism is interlinked with low tolerance for stress or aversive stimuli.^[45] Those who score high in neuroticism are emotionally reactive and vulnerable to stress. They are more likely to interpret ordinary situations as threatening, and minor frustrations as hopelessly difficult. Their negative emotional reactions tend to persist for unusually long periods of time, which means they are often in a bad mood. For instance, neuroticism is connected to a pessimistic approach toward work, confidence that work impedes personal relationships, and apparent anxiety linked with work.^[46] Furthermore, those who score high on neuroticism may display more skin conductance reactivity than those who score low on neuroticism.^[45][47] These problems in emotional regulation can diminish the ability of a person scoring high on neuroticism to think clearly, make decisions, and cope effectively with stress.^{[citation needed]} Lacking contentment in one's life achievements can correlate with high neuroticism scores and increase one's likelihood of falling into clinical depression.^[48] Moreover, individuals high on neuroticism tend to experience more negative life events,^[44][49] but neuroticism also changes in response to positive and negative life experiences.^[44][49]

At the other end of the scale, individuals who score low in neuroticism are less easily upset and are less emotionally reactive. They tend to be calm, emotionally stable, and free from persistent negative feelings. Freedom from negative feelings does not mean that low scorers experience a lot of positive feelings.^[50]

Neuroticism is similar but not identical to being neurotic in the Freudian sense (i.e. neurosis.) Some psychologists prefer to call neuroticism by the term emotional stability to differentiate it from the term neurotic in a career test.

 

 

Edited by eon, 31 May 2015 - 09:07 AM.

[eon]

Are fears ONLY linked to the amgygdala? I started a thread about the connection of my anxiety to my heart defect called mitral valve prolapse (MVP) and there are plenty of finds regarding it. Then again I don't think anxiety is exactly just "fear". So I would think "true fear" is still linked to amygdala but brought on by the anxiety associated with my MVP and with the storage of this "memory" of my anxiety/panic disorder brought on by the MVP, the amygdala has its grip on the memory of it and played into a loop. I wish there was a way to just erase this memory the way one could erase a computer's memory. According to the lengthy research below that anxiety disorders are linked to endocrine diseases, thyroid issues, diabetes and heart defects.

 

 

"As I hope we have demonstrated, endocrine disorders can and do produce both cognitive and behavioral signs of anxiety, panic disorder, and at times even obsessional symptoms in patients. These changes are generally not specific and cannot be easily compartmentalized diagnostically."

 

http://www.drrichard...com/anxiety.htm

Edited by eon, 31 May 2015 - 11:52 AM.

[Strangelove]

I do not think there is toxicity issues with d-cycloserine, its used in 1/5 doses compared with its use for antibiotic purposes.

 

It would be very hard to imagine that the only structure that is involved with fear in the brain is the amygdala, but seems to be the main one. Also as I said there is a distinction in left/right amygdalae with positive and negative affect.

 

http://www.researchg...e5c80000000.pdf

 

As we have seen in a number of other issues there are many pathways to get results. KOR antagonists is another option, worth looking into, as new drugs are coming out.

 

http://www.ncbi.nlm....pubmed/17823306

 

 

 

 

[eon]

I've heard of the KOR antagonist called JDtic, but according to this article that is has been discontinued:

 

http://mentalhealthd...for-depression/

 

Although other newer KOR antagonists are listed as well. I believe someone has mentioned on this thread about the use of a substance that has action on the k-opioid and I believe menthol is one of them as well, but is said to be weak. I'm not sure menthol in peppermint teas I had been drinking is enough.

[eon]

Some interesting news about NSI-189 below:

 

NSI-189 For Depression: New Drug Grows Hippocampus

 

http://mentalhealthd...ws-hippocampus/

 

While this "growth" can be suspect as it may have potential for a tumor growth, according to the article. It didn't state what action the compound has on the brain but from a guess, I'm hoping it's dopaminergic and not much serotonergic.

 

Where are you getting your NSI-189 considering that article stated some pharmaceutical is still studying it? Also, if it gets approved does that mean all OTC online sales from random vendors mean they are selling the compound illegally and may be halted at some point?

 

 

I would really appreciate to be in a flow state all the time, motivated with no irrational fears and high energy.

 

I’d say I’m almost there with the NSI-189 and the tianeptine. My latest project is trying to figure out a way to use both the sodium salt and the sulfate forms of the latter compound in conjunction. Seems to be working quite nicely, but it’s probably going to take me several more weeks to work out the exact dosages and timing. My thinking is this: try to find the smallest possible dose of the sodium salt that confers a just barely perceptible psychoactive effect, and take it at the same time as the sulfate, such that the sulfate prolongs the effect of the sodium salt and lets you down gently after a few hours or so. So far this seems to be working very, very well, and it doesn’t appear to be turning me into a tianeptine junkie.

 

 

Edited by eon, 01 June 2015 - 12:51 AM.

[eon]

Not sure if the answer is in opioids, but there seem to be proof considering those terrorists in the Middle East seem to lack fear, and my assumption is, opium use may have something to do with it? Just my assumption.

 

"An opioid modulator (or opioid receptor modulator) is a drug which has mixed agonist and antagonist actions at different opioid receptors and thus cannot clearly be described as either an opioid agonist or antagonist. An example of an opioid modulator is buprenorphine, which is a partial agonist of the μ-opioid receptor and an antagonist of the κ-opioid receptor.^[1]"

[scottknl]

Dune, Frank Herbert -- The litany against fear:

I must not fear.

Fear is the mind-killer.

Fear is the little-death that brings total obliteration.

I will face my fear.

I will permit it to pass over me and through me.

And when it has gone past I will turn the inner eye to see its path.

Then only I will remain.

 

Meditation can be effective in reducing ineffective fear while retaining the rational fears that protect us. When you look deeply into your own mind and meditate on your own actions, you'll find that much of your own behavior is dictated by your fears; both conscious and unconscious. Once you face these fears and sort thru them, they lose much of their power to influence you in bad ways. Once the fears have been dealt with, you're left with only your skills (mental, physical and social) against those of your opponents.

 

One need not always pop a pill to get an effect.

[sthira]

^^^ beautiful, man. Great post.

[Heisenburger]

Where are you getting your NSI-189 considering that article stated some pharmaceutical is still studying it?

 

[eon]

I'm curious what determines or makes one confident and if confidence somewhat makes one forget their fears? I am on Vyvanse and this is supposed to raise confidence levels which I haven't observed in the beginning but I recently started taking vitamin B12 again and noticed that Vyvanse is better when I take a B12 supplement. For whatever reason, my confidence is a bit better today. I felt no anxiety or fear standing in line of a grocery store as if my focus is on ME and not what I think what people may think of me. Thinking what I think people think of me I think is partially OCD since it's been an obsession. I think anxiety/fears with OCD seem to be worse.

 

Obsessive compulsive disorder as early manifestation of B12 deficiency.

 

http://www.ncbi.nlm....pubmed/22345852