@ Farshad : I think you're going down the wrong road into a never-ending spiral if you think going through all the possible combinations of known and obscure substances is the solution. Mathematically , it will take you a few hundreds of years to test all the combinations at various dosages. And probably damage yourself even more in the process.
If I understood well from your posts, you main problem is social anxiety. Unlike some purely neurological issues like Parkinson's or Alzheimer, most anxiety problems have a very strong psychological aspect in them. And by that, I'm not saying it's 100% psychological, I'm saying a substantial amount of the issue is psychological, on top of having a substantial physical base. Maybe It's 50/50, or 30/70, or 60/40, etc..
It's a feedback loop. The brain rewires itself. It's plastic. A chemical issue creates psychological issues, which in turn will push the brain to rewire itself in a way that creates even more physiological issues, which in turn, etc... It doesn't matter which of the chemical or the psychological started this loop. What matters is that you need to break the loop at some point.
That means you will only be able to solve the problem if you address BOTH the physiological AND the psychological aspects at the same time.
You need to rewire your brain. Chemicals ( whether natural or pharmaceutical ) may help by giving you enough relief of the most annoying symptoms, but in your case not big enough to give you control of your life again. The point is that they should be used as a way to take you out of crisis mode, so that you can start tackling the rest trough therapy. The chemicals in your case should be considered a tool to facilitate the deeper rewiring of your thought processes through therapy. You never mentioned therapy, so I guess it's something you never tried.
Talk to your doctor into recommending a good therapist. I believe it's fully reimbursed in Sweden ? CBT therapy is backed up with hundreds of serious studies, and deemed very efficient in anxiety issues. I personally prefer ACT ( which helped me a lot, and still making progress with it ), but I think you should try the standard CBT first.
If zyprexa or diazepam helped a bit, then ask your doc to get you back on them , not as the key solution, but as a basis to help you lower the shields while tackling the rewiring of your thought processes through therapy.
Sounds reasonable - but, you have to remember - he has Aspergers Syndrome, ak a Autism Spectrum Disorder as well - I'm guessing on top of that, he's got PTSD, since Farshad is a Persian name, so possibly he's a former refugee as well?
All of it could also simply be a result of Autism - the social anxiety.
In autists, social anxiety is NOT illogical and cannot have the same mechanisms governing it as among neurotypicals - so I would expect CBT developed for neurotypicals to be ineffective, or perhaps even inappropriate - since that would be about blunting a natural response to a hostile environment, which is, imho misguided - if there's a real problem, you don't solve it by trying to get the patient to pretend it's not real - the problem will still be there.
On the other hand, I did just find some meta-reviews which have found CBT is effective... Hard to argue against that - I can only assume that these are very talented special therapists whom do research as well, who use very specific Autist-focused techniques to help Autistic people cope with the stress that is Neurotypical behaviour.
Treatment of anxiety in autism spectrum disorders using cognitive behaviour therapy: A systematic review
http://www.tandfonli...518420903236288
Hmm... this study below implies that there is a clear difference between them - that apparently, CBT will be more effective for an Autist if her ENTIRE FAMILY is involved as well - so they can together learn how to modify their behaviours towards each other. This is logical - since the anxiety for an Autist does not come out of the blue - it comes from responses from the people around them as well - learning how to communicate and co-exist in mutually does indeed make much more sense then.
Anxiety Disorders in Typically Developing Youth: Autism Spectrum Symptoms as a Predictor of Cognitive-Behavioral Treatment
https://link.springe...0803-010-1047-2
This article down below seems more neutral in just how effective CBT really is for social anxiety in Autism - but I can't get round the pay-wall to actually read the final, more detailed conclusions regarding which treatments are better and which methods actually show greater promise... Can anyone break the wall and upload the article? Would surely be helpful for our OP - Farshad.
Cognitive-behavioral therapy for anxiety in children diagnosed with autism spectrum disorders: Modification trends
http://www.sciencedi...750946709001184
Btw, Farshad, does your fixation with the amygdala come from reading this study, which found activity abnormalities in the amygdala of autists, when comparing facial images, which was correlated with increased social anxiety?
Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders
http://www.sciencedi...028393210003179
On another note - can you give us examples of when you get social anxiety?
Can you somehow avoid some of the things which trigger your anxiety? Maybe we can figure out some tricks and changes to your life which you can implement, which would MINIMIZE your contact with the triggers?
I'm getting the feeling that you get anxious from the behaviour of neurotypicals, you see - so, the conclusion then, the simplest solution, is it not to NOT hang out so much with neurotypicals? To minimized your contact with them, and instead find AUTISTIC fellows, whom you can socialize with? I've read on multiple boards how yes, socializing with others autists can at first be even MORE scary, since they are so different from neurotypicals, but, in time, once you get somewhat used to the differences, Autistic people often find that true friendship and a better, less anxious life lies in soializing primarily with others on the spectrum.