
Alternative methods to extend telomeres
#1111
Posted 17 September 2025 - 01:49 PM
High dose oral pterostilbene adversely affects cholesterol, but topical can achieve high dose without such effects afaik
Scientists test an anti-aging cream that actually works
"Pterostilbene cream improved wrinkles, skin firmness, collagen, and pore size far better than a control emulsion. The results highlight pterostilbene as a promising natural ingredient for next-generation anti-aging skincare."
https://www.scienced...50914205851.htm
#1112
Posted 17 September 2025 - 02:38 PM
I heard somewhere that telomere elongation can only occur during replication stage. Not sure if true and if this affects telomerase activation.
Yes, that's true, cells have to be in s-phase for the telomere to be accessible (*).
But like so many things in biology it may not be an absolute rule. And this is where short telomeres being more easy to elongate come in, because the end is more accessible.
The telomere end is completely accessible during DNA-replication, as it has been unrolled. And it is completely inaccessible when folded up and tucked in. But in-between these two states there are situations where the telomere end has some accessibility, and this is enhanced with a short telomere because it is more difficult to tuck it in.
This is the proposed mechanism behind rejuvenation of old people using telomerase activators that are not strong enough to lengthen telomeres back to youthful length, but may be strong enough to take you back some of the way, or rather maintain an equilibrium point at some greater length than would otherwise be the case, with greater mortality than is optimal, but lower than it would otherwise have been.
It is virtually impossible to say how many years this might give you, or how much extra health span. But Bill Andrews is 73 and an endurance runner. He doesn't look young. And doesn't look to be getting any younger. But the does look much better than most his age.
(*) It may be a mechanism for inhibiting telomerase activation as well, i.e. short telomeres have one telomerase blocking mechanism removed, but this is not confirmed.
Edited by QuestforLife, 17 September 2025 - 02:40 PM.
#1113
Posted 18 September 2025 - 06:04 PM
Given resveratrol effects and pterostilbene topical effects. It seems like a common sense conclusion is pterostilbene may be able to achieve similar easier.
Pterostilbene raises ldl at high dose, but the high doses would only be needed for a few weeks or months assuming it is as effective as resveratrol at activating telomerase. Given higher bioavailability and longer half life.
One would think someone would test pterostilbene for this in animals or at least in cells.
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#1114
Posted 19 September 2025 - 11:49 AM
Both resveratrol and pterostilbene are two-faced, they seem to inhibit or activate telomerase depending on dose and cell type. As far as I'm concerned, no one has yet figured out what their mechanism of action is, precisely. To me they always seemed like poisons that in certain circumstances end up being hormetic.
#1115
Posted 01 October 2025 - 02:18 PM
https://www.popularm...-age-your-face/
It seems rejuvenating effects are observed if cells are exposed to high enough dose for long enough
#1116
Posted Today, 11:25 AM
Summary of ‘Alternative Methods to Extend Telomeres’ Sept 2018 to Oct 2025
Early work on NAD+
https://www.longecity.org/forum/topic/102169-alternative-methods-to-extend-telomeres/#entry857309
SIRT4
Loss of NAD+ because of telomere shortening
Work on Statin-Sartan protocol
https://www.longecity.org/forum/topic/102169-alternative-methods-to-extend-telomeres/#entry862269
link between ROCK inhibitors and telomerase
https://www.longecity.org/forum/topic/102169-alternative-methods-to-extend-telomeres/#entry864097
possible link with senolytics
https://www.longecity.org/forum/topic/102169-alternative-methods-to-extend-telomeres/#entry864534
using ROCK and mTOR inhibitors to reprogram brain cancer cells into normal neurons
https://www.longecity.org/forum/topic/102169-alternative-methods-to-extend-telomeres/#entry865160
How ROCK inhibitors block differentiation
Feedback on protocol
Summary of ROCK inhibition action on cells
Attempts to come up with alternatives to statin and sartans
Diagram of interventions
Paper linking up ROCK and ECM
ROCK and tgf-b
Mean and Max lifespan extension with a ROCK inhibitor
Work on telomerase activators and other important telomere papers
Royal Jelly
Review of various activators
Asiaticoside
Some other telomeres studies
Effect of antioxidant on telomere shortening in the bone marrow
More on the same, later
Telomere activators and CV diseases
Telomere shortening predicts species life span
using TERC upregulation to increase telomere length in stem cell
Telomerase and Splicing Factor regulators
T cells taking telomere length from other cells
Do stem cell stimulants deplete the bone marrow pool?
Hyperbaric oxygen therapy
Discussion of Blasco paper on hyperlong telomere mice
Discussion of actual in vivo rate of telomere attrition
GDF11 lengthen telomeres in MSCs via TERC upregulation
Possible benefit of Klotho to telomeres
Nucleotides (specifically guanine) for elongation of telomeres: eat Anchovies and Herring!
Blasco and short telomeres in kidney disease plus possible connection of short telomeres and the cancer causing epithelial to mesenchymal transition
What is the most powerful telomerase activator and a comparison of methods of measurement
Melatonin is the best antioxidant for telomeres?
More on melatonin
AKG and telomere length (in mice)
Discussion of a cell permeable, oxidation resistant form of Vit C and telomeres plus follow on discussion of ROS hormesis in some cell types
Various discussions on the bioavailability of Asiatic acid/asiaticoside (a purported telomerase activator) and why you may only want a very small dose
Should we be taking Zinc for our telomeres?
Clear benefits to life expectancy, CVD and Cancer with longer telomeres: a study with 500k people
Ability of endothelial cells to make new lining is telomere length dependent
Caffeine promotes telomerase expression
Dark chocolate for telomeres
Alternatives to a telomere test: NLR and CRP
Hyperfunctional telomerase: do you want more cell division or longer telomeres?
We should be aiming for mouse levels of telomerase, not HELA levels
New intranasal and injectable gene therapy for healthy life extension
New GDF11 telomerase paper in Nature:
Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity
Telomerase increases mitophagy through PINK1 - explanations for my increased exercise tolerance
Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene
Telomere length and telomerase activity in T cells are biomarkers of high performing centenarians
Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging
Are the oncogenic effects of telomerase mediated by methyl transferases?
Loss of GDF11 shortens telomeres
Does Berberine shorten telomeres?
Mitochondrial Telomerase Reverse Transcriptase Protects from Myocardial Ischemia/reperfusion Injury
Naringenin: super supplement?
NMN increases telomere length
Has the telomere theory of aging been proven?
Telomerase is made in the nucleolus
Telomerase protein levels as measured by immunohistochemistry are unreliable
Telomere Shortening in Hematopoietic Stem Cell Transplantation: A Potential Mechanism for Late Graft Failure?
The flaws of methylation clocks
What is Tianshengyuan-1?
Supertelomerase!
Final telomerase protocol
Adding telomerase to symmetric division: a simplified model
Spermidine
Can ultrasound overcome replicative senescence?
Should we take SAMe for telomeres?
Can NO (nitric oxide) increase telomerase activity?
DHA
What is the optimal strategy for slowing telomere loss? It is not telomerase activators
Oxidative Stress in Rat Hearts: a tale of exosomes
IP6 shortens telomeres
TERT without the TERC? Possible Manganese effects
Where does the telomere theory of aging stand at present?
Is the epigenetic age acceleration caused by telomerase activators caused by nucleotide depletion?
More proof that manganese is good for telomeres
A four year intervention study with six years follow up shows selenium and CoEnzyme Q10 prevents telomere shortening in leukocytes and reduces mortality
Main telomerase activation protocol
High dose cycloastragenol
Stunning confirmation of my theory that epitalon does not activate the telomerase gene
TERT activation targets DNA methylation and multiple aging hallmarks
The interesting idea of exosomes full of telomerase to treat ageing
Nicotine is Amazing!
Telovital
View of Aging
Importance of cell size
The Selfish Cell lives longer
Telomeres are NOT passive in aging
Discussion of telomeres and cancer
Senescence and Cancer, again
Are methylation changes with age evidence of a program?
Comments on heterochronic parabiosis
More on Selfish Cell theory of aging (2021)
Age related methylation and the connection with the Selfish Cell Theory of Aging
Plus why aging is cancer
Putting together telomere and hyperfunction theories of aging
Oxidative stress alters global histone modification and DNA methylation
How non-differentiating Selfish (stem) cells come to dominate the stem cell pool; links between methylation, telomerase and ROS
Finding the Culprit: the hormones required for sexual maturity may be the trigger that starts aging via downregulation of TET2
Discussion over whether methylation of gene promoters is protective against stem cell loss and the counter evidence: immortalised cells accumulate such methylation
Discussion of the combined use of telomerase activators, GDF11, AKG, vit A and C
Summing up the Twin Evils of aging
The Evolution of the Selfish Cell
Cancer and the Selfish Cell
Does the Selfish Cell imply programmed or accidental aging?
Finding the Culprit II: Species' cellular ROS level sets aging rate via down regulation of demethylases and failure of Circadian Rhythm
How does the Selfish Cell affect post-mitotic cells?
Why long telomeres won’t make you live forever, but short telomeres mean you’ll die young
Defining the steps that lead to cancer
What are epigenetic Aging tests actually measuring?
A new thesis
The Secret to lengthening telomeres in all cells
The Tortoise and the Hare
Hyperfunctional Telomeres Part II
Paving the way for the 'speeding car': Explaining the benefits of long telomeres in the context of mTOR
Just how much can we inhibit mTOR?
A reanalysis of some epitalon studies and a new take on the DNA mutation theory of aging
Are we being poisoned?
My current thoughts on aging, October 2023
Skin aging
Stem cell competition – can you have too much symmetrical division?
Results
Methylation results from Statin-Sartan protocol
Telomere length improvements via Lifelength
PhenoAge improvements
Epitalon increases methylation age and discussion
Further discussion
Plan to reduce both telomere and methylation age
No improvement in methylation age from 3 months of AKG
Improvement in methylation age from 6 months of AKG
Further improvement in epigenetic age (-6.6 years)
Summary of GDF11 experience with biomarkers
May 2021 Methylation age results
Discussion of reaction times on GDF11
October 2021 Trume Results
Amino Acid results: Do telomerase activators deplete glutamine?
February 2022 Trume Results
Is it time to abandon methylation based aging tests?
Results: March 2023
a theory for why epigenetic aging is transitory:
Sundry
Fatty Acid Oxidation
Starvation and stem cell renewal
See other thread:
Feeding stem cells: the strange case of dietary restriction and alpha lipoic acid
Possible use of pioglitazone with telomerase activators to increase subcutaneous fat without bladder cancer risk
Resveratrol is weird.
Demethylating the klotho promoter with hydrogen sulphide
Melatonin is linked to mitochondrial function and increases TET2 production
Discussion starting here on reversing thymic involution
Comment on gonadal rejuvenation by GDF11
Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
Immortalizing Cells for human consumption
Also tagged with one or more of these keywords: telomeres, nad, nampt, ampk, resveratrol, allicin, methylene blue, nmn, sirtuins, statin
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